Inhibition of autoreactive antibody effects with antibody feedings: a pilot study
This study seeks to determine if tolerance to autoreactive antibody can be achieved by exposing gut-associated lymphocytic tissue (GALT) to the protein. The method involved immunizing rats with AchR after feeding anti-AchR purified from myasthenic plasma or non-specific, pooled human immunoglobulins...
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| Veröffentlicht in: | Journal of neuroimmunology 1999-04, Vol.96 (1), p.1-8 |
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| container_title | Journal of neuroimmunology |
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| creator | Hofmann, W.W Smith, Marion E |
| description | This study seeks to determine if tolerance to autoreactive antibody can be achieved by exposing gut-associated lymphocytic tissue (GALT) to the protein. The method involved immunizing rats with AchR after feeding anti-AchR purified from myasthenic plasma or non-specific, pooled human immunoglobulins. Both feedings improved the neuromuscular block of EAMG, the commercial preparation requiring a tenfold increase in protein concentration. Despite its protective effect, antibody feeding was associated with late levels of serum anti-AchR considerably above those in immunized controls. The hypothesis presented is that the tolerance results from enhanced anti-idiotype production. |
| doi_str_mv | 10.1016/S0165-5728(98)00269-0 |
| format | Article |
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The method involved immunizing rats with AchR after feeding anti-AchR purified from myasthenic plasma or non-specific, pooled human immunoglobulins. Both feedings improved the neuromuscular block of EAMG, the commercial preparation requiring a tenfold increase in protein concentration. Despite its protective effect, antibody feeding was associated with late levels of serum anti-AchR considerably above those in immunized controls. The hypothesis presented is that the tolerance results from enhanced anti-idiotype production.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(98)00269-0</identifier><identifier>PMID: 10227419</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Oral ; Animals ; Autoantibodies - blood ; Autoantibodies - pharmacology ; Cross Reactions ; EAMG ; Electrophysiology ; Female ; Gamma globulin ; gamma-Globulins - analysis ; Humans ; Immune Tolerance ; Immunization ; Intestinal Absorption - immunology ; Myasthenia gravis ; Myasthenia Gravis - immunology ; Myenteric Plexus - immunology ; Oral antibody tolerance ; Pilot Projects ; Plasmapheresis ; Rats ; Rats, Inbred Lew ; Receptors, Cholinergic - immunology ; Torpedo</subject><ispartof>Journal of neuroimmunology, 1999-04, Vol.96 (1), p.1-8</ispartof><rights>1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c387t-93a4b141b227bbccd5203a4a23c59aa95d6244004f9cdcb442588052d67a66c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-5728(98)00269-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10227419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hofmann, W.W</creatorcontrib><creatorcontrib>Smith, Marion E</creatorcontrib><title>Inhibition of autoreactive antibody effects with antibody feedings: a pilot study</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>This study seeks to determine if tolerance to autoreactive antibody can be achieved by exposing gut-associated lymphocytic tissue (GALT) to the protein. The method involved immunizing rats with AchR after feeding anti-AchR purified from myasthenic plasma or non-specific, pooled human immunoglobulins. Both feedings improved the neuromuscular block of EAMG, the commercial preparation requiring a tenfold increase in protein concentration. Despite its protective effect, antibody feeding was associated with late levels of serum anti-AchR considerably above those in immunized controls. 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| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1999-04, Vol.96 (1), p.1-8 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Oral Animals Autoantibodies - blood Autoantibodies - pharmacology Cross Reactions EAMG Electrophysiology Female Gamma globulin gamma-Globulins - analysis Humans Immune Tolerance Immunization Intestinal Absorption - immunology Myasthenia gravis Myasthenia Gravis - immunology Myenteric Plexus - immunology Oral antibody tolerance Pilot Projects Plasmapheresis Rats Rats, Inbred Lew Receptors, Cholinergic - immunology Torpedo |
| title | Inhibition of autoreactive antibody effects with antibody feedings: a pilot study |
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