Modulation of Epidermal Growth Factor Receptor Gene Transcription by a Polymorphic Dinucleotide Repeat in Intron 1

The influence of a highly polymorphic CA dinucleotide repeat in the epidermal growth factor receptor (EGFR) gene on transcription was examined with a quantitative nuclear run-off method. We could demonstrate that transcription of the EGFR gene is inhibited by approximately 80% in alleles with 21 CA...

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Veröffentlicht in:	The Journal of biological chemistry 1999-05, Vol.274 (19), p.13176-13180
Hauptverfasser:	Gebhardt, Frank, Zänker, Kurt S., Brandt, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Line Dinucleotide Repeats DNA Primers Enhancer Elements, Genetic ErbB Receptors - genetics Gene Expression Regulation - genetics Humans Introns Polymorphism, Genetic RNA Precursors - metabolism RNA, Messenger - metabolism Terminator Regions, Genetic Transcription, Genetic - genetics Tumor Cells, Cultured
Online-Zugang:	Volltext
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