Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria

Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasma...

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Veröffentlicht in:	The Journal of infectious diseases 2008-11, Vol.198 (10), p.1550-1553
Hauptverfasser:	van Eijk, Anna M., Ouma, Peter O., Williamson, John, Ter Kuile, Feiko O., Parise, Monica, Otieno, Kephas, Hamel, Mary J., Ayisi, John G., Kariuki, Simon, Kager, Piet A., Slutsker, Laurence
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antimalarials - therapeutic use Biological and medical sciences Blood plasma Dietary Supplements Dosage Drug Combinations Female Folic Acid - administration & dosage Folic Acid - blood Fundamental and applied biological sciences. Psychology Human protozoal diseases Humans Infectious diseases Kenya Malaria Malaria - drug therapy Medical research Medical sciences Medical treatment failures Microbiology Parasites Parasitic diseases Pregnancy Pregnancy Complications, Parasitic - drug therapy Protozoal diseases Pyrimethamine - therapeutic use Risk Factors Rural density Sulfadoxine - therapeutic use Survival Analysis Treatment Failure Women Young Adult
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Zusammenfassung:	Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasma folate levels were determined at enrollment and at day 7. High baseline folate levels, high parasite densities, and age
ISSN:	0022-1899 1537-6613
DOI:	10.1086/592715