Cumene Hydroperoxide-Supported Demethylation Reactions Catalyzed by Cytochrome P450 2B4 Lacking the NH2-Terminal Sequence

Catalytic activities of cytochrome P450 2B4 lacking NH2-terminal amino acids 2-27 (wt Δ2B4) and that of truncated 2B4 containing a Pro to Ser mutation at position 221 were examined in a system supported by cumene hydroperoxide. Demethylation activities of either truncated 2B4 with N-methylaniline, N...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1999-04, Vol.258 (1), p.32-38
Hauptverfasser:	Zhang, Yiqun, Pernecky, Steven J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - metabolism Animals Aryl Hydrocarbon Hydroxylases Benzene Derivatives - metabolism Catalysis Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism cytochrome P450 heterologous expression hydroperoxides Hydroxylation Methylation Microsomes, Liver - enzymology Phosphatidylcholines - metabolism Rabbits Sequence Deletion Steroid Hydroxylases - chemistry Steroid Hydroxylases - metabolism Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!