Epidemiology and control of vancomycin-resistant enterococci in a regional neonatal intensive care unit
BACKGROUND.After the occurrence of two cases of bloodstream infection with vancomycin-resistant enterococci (VRE) in our regional neonatal intensive care unit, we studied the epidemiology of VRE and applied extensive infection control measures to the unit to control VRE transmission. METHODS.Infecti...
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| Veröffentlicht in: | The Pediatric infectious disease journal 1999-04, Vol.18 (4), p.352-356 |
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| creator | MALIK, RAJESH K MONTECALVO, MARISA A REALE, MARIO R LI, KARL MAW, MYINT MUNOZ, JOSE L GEDRIS, CHERYL VAN HORN, KEN CARNEVALE, KEVIN A LEVI, MICHAEL H DWECK, HARRY S |
| description | BACKGROUND.After the occurrence of two cases of bloodstream infection with vancomycin-resistant enterococci (VRE) in our regional neonatal intensive care unit, we studied the epidemiology of VRE and applied extensive infection control measures to the unit to control VRE transmission.
METHODS.Infection control measures applied to the unit included weekly surveillance for VRE colonization; education; cohorting of VRE-positive, VRE-negative and VRE-exposed babies with separate personnel and equipment for each group; use of gowns and gloves on room entry; and hand washing before and after each patient contact. Risk factors for VRE colonization were determined with a stepwise logistic regression model.
RESULTS.Thirty-three (40.2%) babies became colonized with VRE. The VRE colonization rate was reduced from 67% to 7% after implementation of infection control measures. Prolonged antimicrobial treatment and low birth weight were significantly associated with an increased risk of VRE colonization.
CONCLUSION.VRE can spread rapidly among newborns in a regional neonatal intensive care unit. Strict infection control measures can reduce the rate of VRE colonization among neonates. |
| doi_str_mv | 10.1097/00006454-199904000-00009 |
| format | Article |
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METHODS.Infection control measures applied to the unit included weekly surveillance for VRE colonization; education; cohorting of VRE-positive, VRE-negative and VRE-exposed babies with separate personnel and equipment for each group; use of gowns and gloves on room entry; and hand washing before and after each patient contact. Risk factors for VRE colonization were determined with a stepwise logistic regression model.
RESULTS.Thirty-three (40.2%) babies became colonized with VRE. The VRE colonization rate was reduced from 67% to 7% after implementation of infection control measures. Prolonged antimicrobial treatment and low birth weight were significantly associated with an increased risk of VRE colonization.
CONCLUSION.VRE can spread rapidly among newborns in a regional neonatal intensive care unit. Strict infection control measures can reduce the rate of VRE colonization among neonates.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/00006454-199904000-00009</identifier><identifier>PMID: 10223689</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Baltimore, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cross Infection - epidemiology ; Cross Infection - prevention & control ; Drug Resistance, Microbial ; Electrophoresis, Gel, Pulsed-Field ; Enterococcus - drug effects ; Enterococcus - isolation & purification ; Gram-Positive Bacterial Infections - drug therapy ; Gram-Positive Bacterial Infections - epidemiology ; Gram-Positive Bacterial Infections - prevention & control ; Humans ; Infant, Newborn ; Infection Control ; Intensive Care Units, Neonatal ; Medical sciences ; Pharmacology. Drug treatments ; Risk Factors ; Vancomycin - pharmacology</subject><ispartof>The Pediatric infectious disease journal, 1999-04, Vol.18 (4), p.352-356</ispartof><rights>1999 Lippincott Williams & Wilkins, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3859-16093ec214e66809b1335562d2aa3ef9c663ae822290ad5b1c2c182f0ddf85a23</citedby><cites>FETCH-LOGICAL-c3859-16093ec214e66809b1335562d2aa3ef9c663ae822290ad5b1c2c182f0ddf85a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1753606$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10223689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MALIK, RAJESH K</creatorcontrib><creatorcontrib>MONTECALVO, MARISA A</creatorcontrib><creatorcontrib>REALE, MARIO R</creatorcontrib><creatorcontrib>LI, KARL</creatorcontrib><creatorcontrib>MAW, MYINT</creatorcontrib><creatorcontrib>MUNOZ, JOSE L</creatorcontrib><creatorcontrib>GEDRIS, CHERYL</creatorcontrib><creatorcontrib>VAN HORN, KEN</creatorcontrib><creatorcontrib>CARNEVALE, KEVIN A</creatorcontrib><creatorcontrib>LEVI, MICHAEL H</creatorcontrib><creatorcontrib>DWECK, HARRY S</creatorcontrib><title>Epidemiology and control of vancomycin-resistant enterococci in a regional neonatal intensive care unit</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND.After the occurrence of two cases of bloodstream infection with vancomycin-resistant enterococci (VRE) in our regional neonatal intensive care unit, we studied the epidemiology of VRE and applied extensive infection control measures to the unit to control VRE transmission.
METHODS.Infection control measures applied to the unit included weekly surveillance for VRE colonization; education; cohorting of VRE-positive, VRE-negative and VRE-exposed babies with separate personnel and equipment for each group; use of gowns and gloves on room entry; and hand washing before and after each patient contact. Risk factors for VRE colonization were determined with a stepwise logistic regression model.
RESULTS.Thirty-three (40.2%) babies became colonized with VRE. The VRE colonization rate was reduced from 67% to 7% after implementation of infection control measures. Prolonged antimicrobial treatment and low birth weight were significantly associated with an increased risk of VRE colonization.
CONCLUSION.VRE can spread rapidly among newborns in a regional neonatal intensive care unit. Strict infection control measures can reduce the rate of VRE colonization among neonates.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - prevention & control</subject><subject>Drug Resistance, Microbial</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Enterococcus - drug effects</subject><subject>Enterococcus - isolation & purification</subject><subject>Gram-Positive Bacterial Infections - drug therapy</subject><subject>Gram-Positive Bacterial Infections - epidemiology</subject><subject>Gram-Positive Bacterial Infections - prevention & control</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infection Control</subject><subject>Intensive Care Units, Neonatal</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Risk Factors</subject><subject>Vancomycin - pharmacology</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQQK0KVLbQv1D5UHFL64_EsY8VogUJiUt7tmadyWJw7K2dgPbf13S3hQu-jGf0xh69IYRy9oUz039l9ai2axtujGFtzZrnknlHVryTomFG90dkxbThjVRKn5APpdxXQracvScnnAkhlTYrsrnc-gEnn0La7CjEgboU55wCTSN9hOjStHM-NhmLLzPEmWKcMSeXnPPURwo048anCIFGrGGuF1-RWPwjUgcZ6RL9fEaORwgFPx7iKfn1_fLnxVVzc_vj-uLbTeOk7kzDFTMSneAt1rGZWXMpu06JQQBIHI1TSgJqIYRhMHRr7oTjWoxsGEbdgZCn5Hz_7jan3wuW2U6-OAwB6nRLscr0gknTV1DvQZdTKRlHu81-gryznNlnyfafZPtf8t-Sqa2fDn8s6wmHV417qxX4fACgOAhjrh59eeH6TiqmKtbusacUqtPyEJYnzPYOIcx39q0dyz_DBZTV</recordid><startdate>199904</startdate><enddate>199904</enddate><creator>MALIK, RAJESH K</creator><creator>MONTECALVO, MARISA A</creator><creator>REALE, MARIO R</creator><creator>LI, KARL</creator><creator>MAW, MYINT</creator><creator>MUNOZ, JOSE L</creator><creator>GEDRIS, CHERYL</creator><creator>VAN HORN, KEN</creator><creator>CARNEVALE, KEVIN A</creator><creator>LEVI, MICHAEL H</creator><creator>DWECK, HARRY S</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199904</creationdate><title>Epidemiology and control of vancomycin-resistant enterococci in a regional neonatal intensive care unit</title><author>MALIK, RAJESH K ; MONTECALVO, MARISA A ; REALE, MARIO R ; LI, KARL ; MAW, MYINT ; MUNOZ, JOSE L ; GEDRIS, CHERYL ; VAN HORN, KEN ; CARNEVALE, KEVIN A ; LEVI, MICHAEL H ; DWECK, HARRY S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3859-16093ec214e66809b1335562d2aa3ef9c663ae822290ad5b1c2c182f0ddf85a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - prevention & control</topic><topic>Drug Resistance, Microbial</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Enterococcus - drug effects</topic><topic>Enterococcus - isolation & purification</topic><topic>Gram-Positive Bacterial Infections - drug therapy</topic><topic>Gram-Positive Bacterial Infections - epidemiology</topic><topic>Gram-Positive Bacterial Infections - prevention & control</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infection Control</topic><topic>Intensive Care Units, Neonatal</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Risk Factors</topic><topic>Vancomycin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MALIK, RAJESH K</creatorcontrib><creatorcontrib>MONTECALVO, MARISA A</creatorcontrib><creatorcontrib>REALE, MARIO R</creatorcontrib><creatorcontrib>LI, KARL</creatorcontrib><creatorcontrib>MAW, MYINT</creatorcontrib><creatorcontrib>MUNOZ, JOSE L</creatorcontrib><creatorcontrib>GEDRIS, CHERYL</creatorcontrib><creatorcontrib>VAN HORN, KEN</creatorcontrib><creatorcontrib>CARNEVALE, KEVIN A</creatorcontrib><creatorcontrib>LEVI, MICHAEL H</creatorcontrib><creatorcontrib>DWECK, HARRY S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MALIK, RAJESH K</au><au>MONTECALVO, MARISA A</au><au>REALE, MARIO R</au><au>LI, KARL</au><au>MAW, MYINT</au><au>MUNOZ, JOSE L</au><au>GEDRIS, CHERYL</au><au>VAN HORN, KEN</au><au>CARNEVALE, KEVIN A</au><au>LEVI, MICHAEL H</au><au>DWECK, HARRY S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology and control of vancomycin-resistant enterococci in a regional neonatal intensive care unit</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>1999-04</date><risdate>1999</risdate><volume>18</volume><issue>4</issue><spage>352</spage><epage>356</epage><pages>352-356</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>BACKGROUND.After the occurrence of two cases of bloodstream infection with vancomycin-resistant enterococci (VRE) in our regional neonatal intensive care unit, we studied the epidemiology of VRE and applied extensive infection control measures to the unit to control VRE transmission.
METHODS.Infection control measures applied to the unit included weekly surveillance for VRE colonization; education; cohorting of VRE-positive, VRE-negative and VRE-exposed babies with separate personnel and equipment for each group; use of gowns and gloves on room entry; and hand washing before and after each patient contact. Risk factors for VRE colonization were determined with a stepwise logistic regression model.
RESULTS.Thirty-three (40.2%) babies became colonized with VRE. The VRE colonization rate was reduced from 67% to 7% after implementation of infection control measures. Prolonged antimicrobial treatment and low birth weight were significantly associated with an increased risk of VRE colonization.
CONCLUSION.VRE can spread rapidly among newborns in a regional neonatal intensive care unit. Strict infection control measures can reduce the rate of VRE colonization among neonates.</abstract><cop>Baltimore, MD</cop><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10223689</pmid><doi>10.1097/00006454-199904000-00009</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Pediatric infectious disease journal, 1999-04, Vol.18 (4), p.352-356 |
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| subjects | Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cross Infection - epidemiology Cross Infection - prevention & control Drug Resistance, Microbial Electrophoresis, Gel, Pulsed-Field Enterococcus - drug effects Enterococcus - isolation & purification Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - epidemiology Gram-Positive Bacterial Infections - prevention & control Humans Infant, Newborn Infection Control Intensive Care Units, Neonatal Medical sciences Pharmacology. Drug treatments Risk Factors Vancomycin - pharmacology |
| title | Epidemiology and control of vancomycin-resistant enterococci in a regional neonatal intensive care unit |
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