Local vascular response during organ elevation : A model for cerebral effects of upright position and dural puncture
Dural puncture can be followed by postural headache and, in patients with cerebral infections, by brain stem herniation. The present study evaluates whether these complications may be related to the changes in hydrostatic pressure generated by the spinal fluid column when the dural sac surrounding t...
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Veröffentlicht in: | Acta anaesthesiologica Scandinavica 1999-04, Vol.43 (4), p.438-446 |
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description | Dural puncture can be followed by postural headache and, in patients with cerebral infections, by brain stem herniation. The present study evaluates whether these complications may be related to the changes in hydrostatic pressure generated by the spinal fluid column when the dural sac surrounding the cerebrospinal tissue has been punctured.
An isolated cat skeletal muscle enclosed in a plethysmograph connected to a tube served as a model imitating the brain, the cranium and the spinal canal. We investigated effects of organ elevation on tissue pressure, venous collapse (venous outflow resistance) and tissue volume with closed "spinal" tube (intact dural sac) and open "spinal" tube (dural puncture), and effects of compliance of the draining veins.
Organ elevation with closed "spinal" tube induced a decreased tissue pressure, whereas tissue pressure remained unchanged if arterial inflow pressure to the muscle was kept constant. Organ elevation with the "spinal" tube opened distally caused a significantly larger decrease in tissue pressure, venous dilation and disappearance of venous outflow resistance. Transcapillary filtration increased, and the filtration rate was higher with high than with low venous compliance.
If our results are applicable to the brain, changing to an upright position following a lumbar dural puncture may generate a negative hydrostatic force and a negative interstitial cerebral pressure, causing an increased transvascular pressure and dilation of the cerebral outflow veins. The corresponding increase in cerebral blood volume may induce post-spinal headache, and the increased transcapillary pressure may cause increased fluid filtration and brain oedema if the blood-brain barrier is disrupted. |
doi_str_mv | 10.1034/j.1399-6576.1999.430412.x |
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An isolated cat skeletal muscle enclosed in a plethysmograph connected to a tube served as a model imitating the brain, the cranium and the spinal canal. We investigated effects of organ elevation on tissue pressure, venous collapse (venous outflow resistance) and tissue volume with closed "spinal" tube (intact dural sac) and open "spinal" tube (dural puncture), and effects of compliance of the draining veins.
Organ elevation with closed "spinal" tube induced a decreased tissue pressure, whereas tissue pressure remained unchanged if arterial inflow pressure to the muscle was kept constant. Organ elevation with the "spinal" tube opened distally caused a significantly larger decrease in tissue pressure, venous dilation and disappearance of venous outflow resistance. Transcapillary filtration increased, and the filtration rate was higher with high than with low venous compliance.
If our results are applicable to the brain, changing to an upright position following a lumbar dural puncture may generate a negative hydrostatic force and a negative interstitial cerebral pressure, causing an increased transvascular pressure and dilation of the cerebral outflow veins. The corresponding increase in cerebral blood volume may induce post-spinal headache, and the increased transcapillary pressure may cause increased fluid filtration and brain oedema if the blood-brain barrier is disrupted.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1034/j.1399-6576.1999.430412.x</identifier><identifier>PMID: 10225078</identifier><identifier>CODEN: AANEAB</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Blood Pressure - physiology ; Blood Volume ; Blood-Brain Barrier - physiology ; Brain - blood supply ; Brain - physiology ; Brain Diseases - microbiology ; Brain Edema - etiology ; Brain Stem - pathology ; Capillaries - physiology ; Cats ; Cerebral Veins - physiology ; Cerebrospinal Fluid Pressure - physiology ; Cerebrovascular Circulation - physiology ; Disease Models, Animal ; Dura Mater - physiology ; Encephalocele - etiology ; Headache - etiology ; Hydrostatic Pressure ; Local anesthesia. Pain (treatment) ; Medical sciences ; Muscle, Skeletal - blood supply ; Plethysmography - instrumentation ; Posture - physiology ; Spinal Puncture - adverse effects ; Vascular Resistance - physiology ; Vasodilation - physiology ; Veins - physiology</subject><ispartof>Acta anaesthesiologica Scandinavica, 1999-04, Vol.43 (4), p.438-446</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1784250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10225078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KONGSTAD, L</creatorcontrib><creatorcontrib>GRÄNDE, P.-O</creatorcontrib><title>Local vascular response during organ elevation : A model for cerebral effects of upright position and dural puncture</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description>Dural puncture can be followed by postural headache and, in patients with cerebral infections, by brain stem herniation. The present study evaluates whether these complications may be related to the changes in hydrostatic pressure generated by the spinal fluid column when the dural sac surrounding the cerebrospinal tissue has been punctured.
An isolated cat skeletal muscle enclosed in a plethysmograph connected to a tube served as a model imitating the brain, the cranium and the spinal canal. We investigated effects of organ elevation on tissue pressure, venous collapse (venous outflow resistance) and tissue volume with closed "spinal" tube (intact dural sac) and open "spinal" tube (dural puncture), and effects of compliance of the draining veins.
Organ elevation with closed "spinal" tube induced a decreased tissue pressure, whereas tissue pressure remained unchanged if arterial inflow pressure to the muscle was kept constant. Organ elevation with the "spinal" tube opened distally caused a significantly larger decrease in tissue pressure, venous dilation and disappearance of venous outflow resistance. Transcapillary filtration increased, and the filtration rate was higher with high than with low venous compliance.
If our results are applicable to the brain, changing to an upright position following a lumbar dural puncture may generate a negative hydrostatic force and a negative interstitial cerebral pressure, causing an increased transvascular pressure and dilation of the cerebral outflow veins. The corresponding increase in cerebral blood volume may induce post-spinal headache, and the increased transcapillary pressure may cause increased fluid filtration and brain oedema if the blood-brain barrier is disrupted.</description><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - physiology</subject><subject>Blood Volume</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain - blood supply</subject><subject>Brain - physiology</subject><subject>Brain Diseases - microbiology</subject><subject>Brain Edema - etiology</subject><subject>Brain Stem - pathology</subject><subject>Capillaries - physiology</subject><subject>Cats</subject><subject>Cerebral Veins - physiology</subject><subject>Cerebrospinal Fluid Pressure - physiology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Disease Models, Animal</subject><subject>Dura Mater - physiology</subject><subject>Encephalocele - etiology</subject><subject>Headache - etiology</subject><subject>Hydrostatic Pressure</subject><subject>Local anesthesia. Pain (treatment)</subject><subject>Medical sciences</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Plethysmography - instrumentation</subject><subject>Posture - physiology</subject><subject>Spinal Puncture - adverse effects</subject><subject>Vascular Resistance - physiology</subject><subject>Vasodilation - physiology</subject><subject>Veins - physiology</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkFtr4zAQRkXp0qSXv1BUKPtmry62ZPWtlO0FAvuy-yxkeZQ6OJYr2SH99ys3oe3TMMz5ZpiD0A0lOSW8-LXJKVcqE6UUOVVK5QUnBWX5_gQtPyenaEkIoVlJJVug8xg3qeWFUmdoQQljJZHVEo0rb02HdybaqTMBB4iD7yPgZgptv8Y-rE2PoYOdGVvf4zt8j7e-gQ47H7CFAHVIeXAO7Bixd3gaQrt-HfHgY_sRMX0zb0vUMPV2nAJcoh_OdBGujvUC_Xv8_ffhOVv9eXp5uF9lllVizCrGGa2UTR-CqSvXCCiZqJ0SQCW1iggDAppaSKaIYoWC0nIhuXLEQcElv0A_D3uH4N8miKPettFC15ke_BS1UJIRJmdQHUAbfIwBnE5PbE1415ToWbne6FmsnsXqWbk-KNf7lL0-HpnqLTTfkgfHCbg9Akmy6VwwvW3jFyerIoH8P9Bni5Y</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>KONGSTAD, L</creator><creator>GRÄNDE, P.-O</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Local vascular response during organ elevation : A model for cerebral effects of upright position and dural puncture</title><author>KONGSTAD, L ; GRÄNDE, P.-O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-8232189c999eab8fd6e526bf96e171c906ae6edb672909249e5c36739f0fe4373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - physiology</topic><topic>Blood Volume</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Brain - blood supply</topic><topic>Brain - physiology</topic><topic>Brain Diseases - microbiology</topic><topic>Brain Edema - etiology</topic><topic>Brain Stem - pathology</topic><topic>Capillaries - physiology</topic><topic>Cats</topic><topic>Cerebral Veins - physiology</topic><topic>Cerebrospinal Fluid Pressure - physiology</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Disease Models, Animal</topic><topic>Dura Mater - physiology</topic><topic>Encephalocele - etiology</topic><topic>Headache - etiology</topic><topic>Hydrostatic Pressure</topic><topic>Local anesthesia. Pain (treatment)</topic><topic>Medical sciences</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Plethysmography - instrumentation</topic><topic>Posture - physiology</topic><topic>Spinal Puncture - adverse effects</topic><topic>Vascular Resistance - physiology</topic><topic>Vasodilation - physiology</topic><topic>Veins - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KONGSTAD, L</creatorcontrib><creatorcontrib>GRÄNDE, P.-O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KONGSTAD, L</au><au>GRÄNDE, P.-O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local vascular response during organ elevation : A model for cerebral effects of upright position and dural puncture</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>43</volume><issue>4</issue><spage>438</spage><epage>446</epage><pages>438-446</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><coden>AANEAB</coden><abstract>Dural puncture can be followed by postural headache and, in patients with cerebral infections, by brain stem herniation. The present study evaluates whether these complications may be related to the changes in hydrostatic pressure generated by the spinal fluid column when the dural sac surrounding the cerebrospinal tissue has been punctured.
An isolated cat skeletal muscle enclosed in a plethysmograph connected to a tube served as a model imitating the brain, the cranium and the spinal canal. We investigated effects of organ elevation on tissue pressure, venous collapse (venous outflow resistance) and tissue volume with closed "spinal" tube (intact dural sac) and open "spinal" tube (dural puncture), and effects of compliance of the draining veins.
Organ elevation with closed "spinal" tube induced a decreased tissue pressure, whereas tissue pressure remained unchanged if arterial inflow pressure to the muscle was kept constant. Organ elevation with the "spinal" tube opened distally caused a significantly larger decrease in tissue pressure, venous dilation and disappearance of venous outflow resistance. Transcapillary filtration increased, and the filtration rate was higher with high than with low venous compliance.
If our results are applicable to the brain, changing to an upright position following a lumbar dural puncture may generate a negative hydrostatic force and a negative interstitial cerebral pressure, causing an increased transvascular pressure and dilation of the cerebral outflow veins. The corresponding increase in cerebral blood volume may induce post-spinal headache, and the increased transcapillary pressure may cause increased fluid filtration and brain oedema if the blood-brain barrier is disrupted.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>10225078</pmid><doi>10.1034/j.1399-6576.1999.430412.x</doi><tpages>9</tpages></addata></record> |
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subjects | Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood Pressure - physiology Blood Volume Blood-Brain Barrier - physiology Brain - blood supply Brain - physiology Brain Diseases - microbiology Brain Edema - etiology Brain Stem - pathology Capillaries - physiology Cats Cerebral Veins - physiology Cerebrospinal Fluid Pressure - physiology Cerebrovascular Circulation - physiology Disease Models, Animal Dura Mater - physiology Encephalocele - etiology Headache - etiology Hydrostatic Pressure Local anesthesia. Pain (treatment) Medical sciences Muscle, Skeletal - blood supply Plethysmography - instrumentation Posture - physiology Spinal Puncture - adverse effects Vascular Resistance - physiology Vasodilation - physiology Veins - physiology |
title | Local vascular response during organ elevation : A model for cerebral effects of upright position and dural puncture |
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