Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment
A relationship was sought between the tissue concentrations of interleukin (IL)-8, matrix metalloproteinase (MMP)-8 and MMP-9, and the numbers of the various leukocytes infiltrating the lower uterine segment stroma during parturition. Biopsy specimens of the lower uterine segment were obtained from...
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| Veröffentlicht in: | Human reproduction (Oxford) 1999-04, Vol.14 (4), p.1096-1100 |
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| creator | Winkler, M. Fischer, D.-C. Ruck, P. Marx, T. Kaiserling, E. Oberpichler, A. Tschesche, H. Rath, W. |
| description | A relationship was sought between the tissue concentrations of interleukin (IL)-8, matrix metalloproteinase (MMP)-8 and MMP-9, and the numbers of the various leukocytes infiltrating the lower uterine segment stroma during parturition. Biopsy specimens of the lower uterine segment were obtained from 63 women undergoing Caesarean section at various stages of cervical dilatation at term. The concentrations of IL-8, MMP-8 and MMP-9 were determined with enzyme-linked immunosorbent assays, and the leukocytes were quantified immunohistochemically. The median IL-8 concentration (pg/mg total protein) rose significantly from 17.2 at 6 cm dilatation than at >2 cm, reaching maximum values at >6 cm dilatation. The findings in this study support the hypothesis that IL-8-induced infiltration of the cervical stroma by neutrophils and subsequent release of proteinases may play a key role in parturition. |
| doi_str_mv | 10.1093/humrep/14.4.1096 |
| format | Article |
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Biopsy specimens of the lower uterine segment were obtained from 63 women undergoing Caesarean section at various stages of cervical dilatation at term. The concentrations of IL-8, MMP-8 and MMP-9 were determined with enzyme-linked immunosorbent assays, and the leukocytes were quantified immunohistochemically. The median IL-8 concentration (pg/mg total protein) rose significantly from 17.2 at <2 cm dilatation, to 26.5 at 2 to <4 cm dilatation, and 1954.0 at 4–6 cm dilatation, and remained at approximately this concentration at >6 cm dilatation. The median MMP-8 concentration (ng/mg total protein) increased significantly from 32.2 at <2 cm dilatation to 114.2 at >6 cm dilatation. The median MMP-9 concentration (ng/mg total protein) rose significantly from 15.4 at <2 cm dilatation to 102.1 at >6 cm dilatation. The number of neutrophils was significantly higher at 4–6 cm and >6 cm dilatation than at >2 cm, reaching maximum values at >6 cm dilatation. The findings in this study support the hypothesis that IL-8-induced infiltration of the cervical stroma by neutrophils and subsequent release of proteinases may play a key role in parturition.</description><identifier>ISSN: 0268-1161</identifier><identifier>ISSN: 1460-2350</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/14.4.1096</identifier><identifier>PMID: 10221247</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; cervix uteri ; Collagenases - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Humans ; interleukin-8 ; Interleukin-8 - physiology ; Labor, Obstetric - physiology ; Leukocyte Count ; Matrix Metalloproteinase 8 ; Matrix Metalloproteinase 9 ; matrix metalloproteinases ; neutrophils ; Neutrophils - pathology ; Neutrophils - physiology ; parturition ; Pregnancy ; Pregnancy. Parturition. Lactation ; Uterus - physiology ; Vertebrates: reproduction</subject><ispartof>Human reproduction (Oxford), 1999-04, Vol.14 (4), p.1096-1100</ispartof><rights>European Society of Human Reproduction and Embryology 1999</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Apr 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-ce95ec64aa58bf4d091254d6ad8705144520be84ad07446ffdc98530531f25523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1583,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1787221$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10221247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winkler, M.</creatorcontrib><creatorcontrib>Fischer, D.-C.</creatorcontrib><creatorcontrib>Ruck, P.</creatorcontrib><creatorcontrib>Marx, T.</creatorcontrib><creatorcontrib>Kaiserling, E.</creatorcontrib><creatorcontrib>Oberpichler, A.</creatorcontrib><creatorcontrib>Tschesche, H.</creatorcontrib><creatorcontrib>Rath, W.</creatorcontrib><title>Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>A relationship was sought between the tissue concentrations of interleukin (IL)-8, matrix metalloproteinase (MMP)-8 and MMP-9, and the numbers of the various leukocytes infiltrating the lower uterine segment stroma during parturition. Biopsy specimens of the lower uterine segment were obtained from 63 women undergoing Caesarean section at various stages of cervical dilatation at term. The concentrations of IL-8, MMP-8 and MMP-9 were determined with enzyme-linked immunosorbent assays, and the leukocytes were quantified immunohistochemically. The median IL-8 concentration (pg/mg total protein) rose significantly from 17.2 at <2 cm dilatation, to 26.5 at 2 to <4 cm dilatation, and 1954.0 at 4–6 cm dilatation, and remained at approximately this concentration at >6 cm dilatation. The median MMP-8 concentration (ng/mg total protein) increased significantly from 32.2 at <2 cm dilatation to 114.2 at >6 cm dilatation. The median MMP-9 concentration (ng/mg total protein) rose significantly from 15.4 at <2 cm dilatation to 102.1 at >6 cm dilatation. The number of neutrophils was significantly higher at 4–6 cm and >6 cm dilatation than at >2 cm, reaching maximum values at >6 cm dilatation. The findings in this study support the hypothesis that IL-8-induced infiltration of the cervical stroma by neutrophils and subsequent release of proteinases may play a key role in parturition.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>cervix uteri</subject><subject>Collagenases - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>interleukin-8</subject><subject>Interleukin-8 - physiology</subject><subject>Labor, Obstetric - physiology</subject><subject>Leukocyte Count</subject><subject>Matrix Metalloproteinase 8</subject><subject>Matrix Metalloproteinase 9</subject><subject>matrix metalloproteinases</subject><subject>neutrophils</subject><subject>Neutrophils - pathology</subject><subject>Neutrophils - physiology</subject><subject>parturition</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Uterus - physiology</subject><subject>Vertebrates: reproduction</subject><issn>0268-1161</issn><issn>1460-2350</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2L1TAUhosoznV070qCiBvpTJImaepORmeuMKALHcRNyE1PvZlJ05oP1H_gzza1FxU3CoEczvucNx9vVT0k-ITgrjnd5zHAfErYCVsa4la1IUzgmjYc3642mApZEyLIUXUvxmuMSynF3eqIYEoJZe2m-v5Wh5SDTXbySCeUIIzP0ayDdg4cst4E0BFiqcoqqoN8Y30tkfY9msOUwPoCIDN5Az4FvTjFn6qHnMI0760ravZp8Uh7QG76AgHlYmY9oAifxjJ4v7ozaBfhwWE_rt6fv3p3tq0v31y8PntxWRvWyVQb6DgYwbTmcjewHneEctYL3csWc8IYp3gHkuket4yJYehNJ3mDeUMGyjltjqunq2-5--cMManRRgPOaQ9Tjkp0LV3-6Z8gxbwrGcgCPv4LvJ5y8OURihIipeyYKBBeIROmGAMMag521OGbIlgtWao1S0WYYktjGXl08M27Efo_BtbwCvDkAOhotBuC9sbG31wr20IW7NmKTXn-n1PrlbYxwddfvA43SrRNy9X2w0f18upi255fEUWaH5F9x1o</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Winkler, M.</creator><creator>Fischer, D.-C.</creator><creator>Ruck, P.</creator><creator>Marx, T.</creator><creator>Kaiserling, E.</creator><creator>Oberpichler, A.</creator><creator>Tschesche, H.</creator><creator>Rath, W.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment</title><author>Winkler, M. ; Fischer, D.-C. ; Ruck, P. ; Marx, T. ; Kaiserling, E. ; Oberpichler, A. ; Tschesche, H. ; Rath, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-ce95ec64aa58bf4d091254d6ad8705144520be84ad07446ffdc98530531f25523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>cervix uteri</topic><topic>Collagenases - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>interleukin-8</topic><topic>Interleukin-8 - physiology</topic><topic>Labor, Obstetric - physiology</topic><topic>Leukocyte Count</topic><topic>Matrix Metalloproteinase 8</topic><topic>Matrix Metalloproteinase 9</topic><topic>matrix metalloproteinases</topic><topic>neutrophils</topic><topic>Neutrophils - pathology</topic><topic>Neutrophils - physiology</topic><topic>parturition</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Uterus - physiology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winkler, M.</creatorcontrib><creatorcontrib>Fischer, D.-C.</creatorcontrib><creatorcontrib>Ruck, P.</creatorcontrib><creatorcontrib>Marx, T.</creatorcontrib><creatorcontrib>Kaiserling, E.</creatorcontrib><creatorcontrib>Oberpichler, A.</creatorcontrib><creatorcontrib>Tschesche, H.</creatorcontrib><creatorcontrib>Rath, W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winkler, M.</au><au>Fischer, D.-C.</au><au>Ruck, P.</au><au>Marx, T.</au><au>Kaiserling, E.</au><au>Oberpichler, A.</au><au>Tschesche, H.</au><au>Rath, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>14</volume><issue>4</issue><spage>1096</spage><epage>1100</epage><pages>1096-1100</pages><issn>0268-1161</issn><issn>1460-2350</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>A relationship was sought between the tissue concentrations of interleukin (IL)-8, matrix metalloproteinase (MMP)-8 and MMP-9, and the numbers of the various leukocytes infiltrating the lower uterine segment stroma during parturition. Biopsy specimens of the lower uterine segment were obtained from 63 women undergoing Caesarean section at various stages of cervical dilatation at term. The concentrations of IL-8, MMP-8 and MMP-9 were determined with enzyme-linked immunosorbent assays, and the leukocytes were quantified immunohistochemically. The median IL-8 concentration (pg/mg total protein) rose significantly from 17.2 at <2 cm dilatation, to 26.5 at 2 to <4 cm dilatation, and 1954.0 at 4–6 cm dilatation, and remained at approximately this concentration at >6 cm dilatation. The median MMP-8 concentration (ng/mg total protein) increased significantly from 32.2 at <2 cm dilatation to 114.2 at >6 cm dilatation. The median MMP-9 concentration (ng/mg total protein) rose significantly from 15.4 at <2 cm dilatation to 102.1 at >6 cm dilatation. The number of neutrophils was significantly higher at 4–6 cm and >6 cm dilatation than at >2 cm, reaching maximum values at >6 cm dilatation. The findings in this study support the hypothesis that IL-8-induced infiltration of the cervical stroma by neutrophils and subsequent release of proteinases may play a key role in parturition.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10221247</pmid><doi>10.1093/humrep/14.4.1096</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human reproduction (Oxford), 1999-04, Vol.14 (4), p.1096-1100 |
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| subjects | Adult Biological and medical sciences cervix uteri Collagenases - physiology Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans interleukin-8 Interleukin-8 - physiology Labor, Obstetric - physiology Leukocyte Count Matrix Metalloproteinase 8 Matrix Metalloproteinase 9 matrix metalloproteinases neutrophils Neutrophils - pathology Neutrophils - physiology parturition Pregnancy Pregnancy. Parturition. Lactation Uterus - physiology Vertebrates: reproduction |
| title | Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment |
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