Stimulation of Different Subtypes of Angiotensin II Receptors, AT1 and AT2 Receptors, Regulates STAT Activation by Negative Crosstalk
Angiotensin II type 2 (AT2) receptor exerts an inhibitory action on cell growth. In the present study, we report that the stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosp...
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| Veröffentlicht in: | Circulation research 1999-04, Vol.84 (8), p.876-882 |
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| container_title | Circulation research |
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| creator | Horiuchi, Masatsugu Hayashida, Wataru Akishita, Masahiro Tamura, Kouichi Daviet, Laurent Lehtonen, Jukka Y.A Dzau, Victor J |
| description | Angiotensin II type 2 (AT2) receptor exerts an inhibitory action on cell growth. In the present study, we report that the stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1 alpha/beta, STAT2, and STAT3 without influence on Janus kinase. AT2 receptor activation also inhibited the tyrosine phosphorylation of STAT1 alpha/beta induced by interferon-gamma, epidermal growth factor, and platelet-derived growth factor. Similar effects of AT2 receptor were observed in R3T3 fibroblast and mouse fetal VSMCs, which express endogenous AT2 receptor. Moreover, AT2 receptor inhibited serine phosphorylation of STAT1 alpha and STAT3 via the inhibition of extracellular signal-regulated kinase (ERK) activation. Stimulation of AT2 receptor inhibited the binding of STATs with sis-inducing element in c-fos promoter, resulting in decreased c-fos expression. Taken together, our results suggest that AT2 receptor can crosstalk negatively with multiple families of growth receptors by inhibiting ERK and STAT activation. (Circ Res. 1999;84:876-882.) |
| doi_str_mv | 10.1161/01.RES.84.8.876 |
| format | Article |
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In the present study, we report that the stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1 alpha/beta, STAT2, and STAT3 without influence on Janus kinase. AT2 receptor activation also inhibited the tyrosine phosphorylation of STAT1 alpha/beta induced by interferon-gamma, epidermal growth factor, and platelet-derived growth factor. Similar effects of AT2 receptor were observed in R3T3 fibroblast and mouse fetal VSMCs, which express endogenous AT2 receptor. Moreover, AT2 receptor inhibited serine phosphorylation of STAT1 alpha and STAT3 via the inhibition of extracellular signal-regulated kinase (ERK) activation. Stimulation of AT2 receptor inhibited the binding of STATs with sis-inducing element in c-fos promoter, resulting in decreased c-fos expression. Taken together, our results suggest that AT2 receptor can crosstalk negatively with multiple families of growth receptors by inhibiting ERK and STAT activation. (Circ Res. 1999;84:876-882.)</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.84.8.876</identifier><identifier>PMID: 10222333</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Animals ; Biological and medical sciences ; Biological Transport ; Blood vessels and receptors ; Cell Nucleus - metabolism ; Cells, Cultured ; DNA-Binding Proteins - metabolism ; Fundamental and applied biological sciences. Psychology ; Mice ; Phosphorylation ; Rats ; Rats, Sprague-Dawley ; Receptors, Angiotensin - classification ; Receptors, Angiotensin - physiology ; Serine - metabolism ; STAT2 Transcription Factor ; STAT3 Transcription Factor ; Trans-Activators - metabolism ; Tyrosine - metabolism ; Vertebrates: cardiovascular system</subject><ispartof>Circulation research, 1999-04, Vol.84 (8), p.876-882</ispartof><rights>1999 American Heart Association, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. 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In the present study, we report that the stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1 alpha/beta, STAT2, and STAT3 without influence on Janus kinase. AT2 receptor activation also inhibited the tyrosine phosphorylation of STAT1 alpha/beta induced by interferon-gamma, epidermal growth factor, and platelet-derived growth factor. Similar effects of AT2 receptor were observed in R3T3 fibroblast and mouse fetal VSMCs, which express endogenous AT2 receptor. Moreover, AT2 receptor inhibited serine phosphorylation of STAT1 alpha and STAT3 via the inhibition of extracellular signal-regulated kinase (ERK) activation. Stimulation of AT2 receptor inhibited the binding of STATs with sis-inducing element in c-fos promoter, resulting in decreased c-fos expression. Taken together, our results suggest that AT2 receptor can crosstalk negatively with multiple families of growth receptors by inhibiting ERK and STAT activation. (Circ Res. 1999;84:876-882.)</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Blood vessels and receptors</subject><subject>Cell Nucleus - metabolism</subject><subject>Cells, Cultured</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mice</subject><subject>Phosphorylation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Angiotensin - classification</subject><subject>Receptors, Angiotensin - physiology</subject><subject>Serine - metabolism</subject><subject>STAT2 Transcription Factor</subject><subject>STAT3 Transcription Factor</subject><subject>Trans-Activators - metabolism</subject><subject>Tyrosine - metabolism</subject><subject>Vertebrates: cardiovascular system</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU-P0zAQxS0EYkvhzA1ZCHEiYcZ2_vhYlV2otAKpLefIccdtdtOk2M6u-gH43puqRSBOb_T0mzejGcbeIqSIOX4GTJfXq7RUaZmWRf6MTTATKlFZgc_ZBAB0UkgJV-xVCHcAqKTQL9kVghBCSjlhv1ex2Q-tiU3f8d7xL41z5KmLfDXU8XigcHJn3bbpI3Wh6fhiwZdk6RB7Hz7x2Rq56Tajin_tJW1PoWP3aj1b85mNzcN5Rn3k32k71g_E574PIZr2_jV74Uwb6M1Fp-znzfV6_i25_fF1MZ_dJjuRaZHkRudghZLaCU3KFKTLDYgsU7WzNZFyOdZWZbXLHFptZQHlRglUhUFX57mcso_n3IPvfw0UYrVvgqW2NR31Q6hyXQhAKEfw_X_gXT_4btytEigUZsV41il7d4GGek-b6uCbvfHH6s91R-DDBTDBmtZ509km_OVKkDi-ZMrUGXvs20g-3LfDI_lqR6aNu2p8IkhAkaDWGpQESE6WkE8L95ds</recordid><startdate>19990430</startdate><enddate>19990430</enddate><creator>Horiuchi, Masatsugu</creator><creator>Hayashida, Wataru</creator><creator>Akishita, Masahiro</creator><creator>Tamura, Kouichi</creator><creator>Daviet, Laurent</creator><creator>Lehtonen, Jukka Y.A</creator><creator>Dzau, Victor J</creator><general>American Heart Association, Inc</general><general>Lippincott</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>19990430</creationdate><title>Stimulation of Different Subtypes of Angiotensin II Receptors, AT1 and AT2 Receptors, Regulates STAT Activation by Negative Crosstalk</title><author>Horiuchi, Masatsugu ; Hayashida, Wataru ; Akishita, Masahiro ; Tamura, Kouichi ; Daviet, Laurent ; Lehtonen, Jukka Y.A ; Dzau, Victor J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h2592-6a960c2439f29e4a7e98d02554bfcbee4f61bc45bf5f1c9c3708d42147a1fb663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Blood vessels and receptors</topic><topic>Cell Nucleus - metabolism</topic><topic>Cells, Cultured</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. 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In the present study, we report that the stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1 alpha/beta, STAT2, and STAT3 without influence on Janus kinase. AT2 receptor activation also inhibited the tyrosine phosphorylation of STAT1 alpha/beta induced by interferon-gamma, epidermal growth factor, and platelet-derived growth factor. Similar effects of AT2 receptor were observed in R3T3 fibroblast and mouse fetal VSMCs, which express endogenous AT2 receptor. Moreover, AT2 receptor inhibited serine phosphorylation of STAT1 alpha and STAT3 via the inhibition of extracellular signal-regulated kinase (ERK) activation. Stimulation of AT2 receptor inhibited the binding of STATs with sis-inducing element in c-fos promoter, resulting in decreased c-fos expression. 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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Biological Transport Blood vessels and receptors Cell Nucleus - metabolism Cells, Cultured DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Mice Phosphorylation Rats Rats, Sprague-Dawley Receptors, Angiotensin - classification Receptors, Angiotensin - physiology Serine - metabolism STAT2 Transcription Factor STAT3 Transcription Factor Trans-Activators - metabolism Tyrosine - metabolism Vertebrates: cardiovascular system |
| title | Stimulation of Different Subtypes of Angiotensin II Receptors, AT1 and AT2 Receptors, Regulates STAT Activation by Negative Crosstalk |
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