Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects

Retarded capsules containing 1 mg bumetanide (BN) were prepared and their in vivo absoption and diuretic effect after oral administration in human subjects were studied. For comparison, commercially available tablets of BN (rapid effect) were administered orally. The mean value of the area under the...

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Veröffentlicht in:Biological & pharmaceutical bulletin 1999/03/15, Vol.22(3), pp.275-280
Hauptverfasser: YAGI, Naomi, KIUCHI, Takashi, SATOH, Hayato, ISHIKAWA, Yohko, TAKADA, Masahiko, SEKIKAWA, Hitoshi
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container_end_page 280
container_issue 3
container_start_page 275
container_title Biological & pharmaceutical bulletin
container_volume 22
creator YAGI, Naomi
KIUCHI, Takashi
SATOH, Hayato
ISHIKAWA, Yohko
TAKADA, Masahiko
SEKIKAWA, Hitoshi
description Retarded capsules containing 1 mg bumetanide (BN) were prepared and their in vivo absoption and diuretic effect after oral administration in human subjects were studied. For comparison, commercially available tablets of BN (rapid effect) were administered orally. The mean value of the area under the plasma concentration time curve (AUC) after administration of retarded capsules was about one half that of the tablets. The mean maximum plasma concentration (Cmax) and the mean maximum urinary excretion rate of BN after administration of retarded capsules were also about one half compared to those of the tablets. Cumulative urinary volumes for 24 h, however, were not significantly different between retarded capsules and tablets. Peak times for the urinary excretion rate of BN, urine flow rate and the Cmax after administration of retarded capsules were significantly delayed compared to those of tablets. Clockwise hysteresis relationships between the urine flow rate and plasm concentration or urinary excretion rate of BN were observed after administration of retarded capsules. From these studies, retarded capsules of BN possessed a mild diuresis and its diuretic effect was maintained for a few hours after administration.
doi_str_mv 10.1248/bpb.22.275
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From these studies, retarded capsules of BN possessed a mild diuresis and its diuretic effect was maintained for a few hours after administration.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>bumetanide</subject><subject>Bumetanide - pharmacokinetics</subject><subject>Bumetanide - pharmacology</subject><subject>Capsules</subject><subject>clockwise hysteresis</subject><subject>Delayed-Action Preparations</subject><subject>diuretic effect</subject><subject>Diuretics - pharmacokinetics</subject><subject>Diuretics - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Values</subject><subject>retarded capsule</subject><subject>tablet</subject><subject>Tablets</subject><subject>Urinary system</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkduKFDEQhoMo7uzqjQ8gAcULoccknU53X-6Ou66wIHi4DpWTZuhOjzkI-_ammXEVb6qg6uOvw4_QC0q2lPHhnTqoLWNb1neP0Ia2vG86RrvHaENGOjSCdsMZOk9pTwjpCWufojNKGCNs4Bs0X_kFfoGfQPnJ53sMweD3vkSbvcbXzlmdMbhsI740sw8-5QjZLwEvDn-2GaKxBu_gkMpk01q8KnMtB28s9gHflhkC_lLUvgqlZ-iJgynZ56d8gb7dXH_d3TZ3nz583F3eNVqwITdGG6GAETeSljBat-1065TQwA3prCGCcTsa0arRGcadM1orCgKscmA4by_Qm6PuIS4_i01Zzj5pO00Q7FKSFGNPx06s4Kv_wP1SYqi7Scp5fR_tBavU2yOl45JStE4eop8h3ktK5GqBrBZIxmS1oMIvT5JFzdb8gx5_XoHXJwCShslFCNqnv1zf16tXnd0R26cM3-1DH2J1ZrLrSDqO7Tr2T-i7h67-AVHa0P4GZ6anTw</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>YAGI, Naomi</creator><creator>KIUCHI, Takashi</creator><creator>SATOH, Hayato</creator><creator>ISHIKAWA, Yohko</creator><creator>TAKADA, Masahiko</creator><creator>SEKIKAWA, Hitoshi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects</title><author>YAGI, Naomi ; KIUCHI, Takashi ; SATOH, Hayato ; ISHIKAWA, Yohko ; TAKADA, Masahiko ; SEKIKAWA, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c628t-dcd6ba20f9030211025c3fb6ca4d05ed0624e9d63b9fd24ffdccb1a6aebfad443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>bumetanide</topic><topic>Bumetanide - pharmacokinetics</topic><topic>Bumetanide - pharmacology</topic><topic>Capsules</topic><topic>clockwise hysteresis</topic><topic>Delayed-Action Preparations</topic><topic>diuretic effect</topic><topic>Diuretics - pharmacokinetics</topic><topic>Diuretics - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. 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subjects Administration, Oral
Adult
bioavailability
Biological and medical sciences
Biological Availability
bumetanide
Bumetanide - pharmacokinetics
Bumetanide - pharmacology
Capsules
clockwise hysteresis
Delayed-Action Preparations
diuretic effect
Diuretics - pharmacokinetics
Diuretics - pharmacology
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Reference Values
retarded capsule
tablet
Tablets
Urinary system
title Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects
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