Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects
Retarded capsules containing 1 mg bumetanide (BN) were prepared and their in vivo absoption and diuretic effect after oral administration in human subjects were studied. For comparison, commercially available tablets of BN (rapid effect) were administered orally. The mean value of the area under the...
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Veröffentlicht in: | Biological & pharmaceutical bulletin 1999/03/15, Vol.22(3), pp.275-280 |
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creator | YAGI, Naomi KIUCHI, Takashi SATOH, Hayato ISHIKAWA, Yohko TAKADA, Masahiko SEKIKAWA, Hitoshi |
description | Retarded capsules containing 1 mg bumetanide (BN) were prepared and their in vivo absoption and diuretic effect after oral administration in human subjects were studied. For comparison, commercially available tablets of BN (rapid effect) were administered orally. The mean value of the area under the plasma concentration time curve (AUC) after administration of retarded capsules was about one half that of the tablets. The mean maximum plasma concentration (Cmax) and the mean maximum urinary excretion rate of BN after administration of retarded capsules were also about one half compared to those of the tablets. Cumulative urinary volumes for 24 h, however, were not significantly different between retarded capsules and tablets. Peak times for the urinary excretion rate of BN, urine flow rate and the Cmax after administration of retarded capsules were significantly delayed compared to those of tablets. Clockwise hysteresis relationships between the urine flow rate and plasm concentration or urinary excretion rate of BN were observed after administration of retarded capsules. From these studies, retarded capsules of BN possessed a mild diuresis and its diuretic effect was maintained for a few hours after administration. |
doi_str_mv | 10.1248/bpb.22.275 |
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For comparison, commercially available tablets of BN (rapid effect) were administered orally. The mean value of the area under the plasma concentration time curve (AUC) after administration of retarded capsules was about one half that of the tablets. The mean maximum plasma concentration (Cmax) and the mean maximum urinary excretion rate of BN after administration of retarded capsules were also about one half compared to those of the tablets. Cumulative urinary volumes for 24 h, however, were not significantly different between retarded capsules and tablets. Peak times for the urinary excretion rate of BN, urine flow rate and the Cmax after administration of retarded capsules were significantly delayed compared to those of tablets. Clockwise hysteresis relationships between the urine flow rate and plasm concentration or urinary excretion rate of BN were observed after administration of retarded capsules. From these studies, retarded capsules of BN possessed a mild diuresis and its diuretic effect was maintained for a few hours after administration.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.22.275</identifier><identifier>PMID: 10220284</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Administration, Oral ; Adult ; bioavailability ; Biological and medical sciences ; Biological Availability ; bumetanide ; Bumetanide - pharmacokinetics ; Bumetanide - pharmacology ; Capsules ; clockwise hysteresis ; Delayed-Action Preparations ; diuretic effect ; Diuretics - pharmacokinetics ; Diuretics - pharmacology ; Humans ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Reference Values ; retarded capsule ; tablet ; Tablets ; Urinary system</subject><ispartof>Biological and Pharmaceutical Bulletin, 1999/03/15, Vol.22(3), pp.275-280</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c628t-dcd6ba20f9030211025c3fb6ca4d05ed0624e9d63b9fd24ffdccb1a6aebfad443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1770305$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10220284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAGI, Naomi</creatorcontrib><creatorcontrib>KIUCHI, Takashi</creatorcontrib><creatorcontrib>SATOH, Hayato</creatorcontrib><creatorcontrib>ISHIKAWA, Yohko</creatorcontrib><creatorcontrib>TAKADA, Masahiko</creatorcontrib><creatorcontrib>SEKIKAWA, Hitoshi</creatorcontrib><title>Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Retarded capsules containing 1 mg bumetanide (BN) were prepared and their in vivo absoption and diuretic effect after oral administration in human subjects were studied. For comparison, commercially available tablets of BN (rapid effect) were administered orally. The mean value of the area under the plasma concentration time curve (AUC) after administration of retarded capsules was about one half that of the tablets. The mean maximum plasma concentration (Cmax) and the mean maximum urinary excretion rate of BN after administration of retarded capsules were also about one half compared to those of the tablets. Cumulative urinary volumes for 24 h, however, were not significantly different between retarded capsules and tablets. Peak times for the urinary excretion rate of BN, urine flow rate and the Cmax after administration of retarded capsules were significantly delayed compared to those of tablets. Clockwise hysteresis relationships between the urine flow rate and plasm concentration or urinary excretion rate of BN were observed after administration of retarded capsules. From these studies, retarded capsules of BN possessed a mild diuresis and its diuretic effect was maintained for a few hours after administration.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>bumetanide</subject><subject>Bumetanide - pharmacokinetics</subject><subject>Bumetanide - pharmacology</subject><subject>Capsules</subject><subject>clockwise hysteresis</subject><subject>Delayed-Action Preparations</subject><subject>diuretic effect</subject><subject>Diuretics - pharmacokinetics</subject><subject>Diuretics - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Values</subject><subject>retarded capsule</subject><subject>tablet</subject><subject>Tablets</subject><subject>Urinary system</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkduKFDEQhoMo7uzqjQ8gAcULoccknU53X-6Ou66wIHi4DpWTZuhOjzkI-_ammXEVb6qg6uOvw4_QC0q2lPHhnTqoLWNb1neP0Ia2vG86RrvHaENGOjSCdsMZOk9pTwjpCWufojNKGCNs4Bs0X_kFfoGfQPnJ53sMweD3vkSbvcbXzlmdMbhsI740sw8-5QjZLwEvDn-2GaKxBu_gkMpk01q8KnMtB28s9gHflhkC_lLUvgqlZ-iJgynZ56d8gb7dXH_d3TZ3nz583F3eNVqwITdGG6GAETeSljBat-1065TQwA3prCGCcTsa0arRGcadM1orCgKscmA4by_Qm6PuIS4_i01Zzj5pO00Q7FKSFGNPx06s4Kv_wP1SYqi7Scp5fR_tBavU2yOl45JStE4eop8h3ktK5GqBrBZIxmS1oMIvT5JFzdb8gx5_XoHXJwCShslFCNqnv1zf16tXnd0R26cM3-1DH2J1ZrLrSDqO7Tr2T-i7h67-AVHa0P4GZ6anTw</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>YAGI, Naomi</creator><creator>KIUCHI, Takashi</creator><creator>SATOH, Hayato</creator><creator>ISHIKAWA, Yohko</creator><creator>TAKADA, Masahiko</creator><creator>SEKIKAWA, Hitoshi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects</title><author>YAGI, Naomi ; KIUCHI, Takashi ; SATOH, Hayato ; ISHIKAWA, Yohko ; TAKADA, Masahiko ; SEKIKAWA, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c628t-dcd6ba20f9030211025c3fb6ca4d05ed0624e9d63b9fd24ffdccb1a6aebfad443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>bumetanide</topic><topic>Bumetanide - pharmacokinetics</topic><topic>Bumetanide - pharmacology</topic><topic>Capsules</topic><topic>clockwise hysteresis</topic><topic>Delayed-Action Preparations</topic><topic>diuretic effect</topic><topic>Diuretics - pharmacokinetics</topic><topic>Diuretics - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Reference Values</topic><topic>retarded capsule</topic><topic>tablet</topic><topic>Tablets</topic><topic>Urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YAGI, Naomi</creatorcontrib><creatorcontrib>KIUCHI, Takashi</creatorcontrib><creatorcontrib>SATOH, Hayato</creatorcontrib><creatorcontrib>ISHIKAWA, Yohko</creatorcontrib><creatorcontrib>TAKADA, Masahiko</creatorcontrib><creatorcontrib>SEKIKAWA, Hitoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAGI, Naomi</au><au>KIUCHI, Takashi</au><au>SATOH, Hayato</au><au>ISHIKAWA, Yohko</au><au>TAKADA, Masahiko</au><au>SEKIKAWA, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>22</volume><issue>3</issue><spage>275</spage><epage>280</epage><pages>275-280</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Retarded capsules containing 1 mg bumetanide (BN) were prepared and their in vivo absoption and diuretic effect after oral administration in human subjects were studied. For comparison, commercially available tablets of BN (rapid effect) were administered orally. The mean value of the area under the plasma concentration time curve (AUC) after administration of retarded capsules was about one half that of the tablets. The mean maximum plasma concentration (Cmax) and the mean maximum urinary excretion rate of BN after administration of retarded capsules were also about one half compared to those of the tablets. Cumulative urinary volumes for 24 h, however, were not significantly different between retarded capsules and tablets. Peak times for the urinary excretion rate of BN, urine flow rate and the Cmax after administration of retarded capsules were significantly delayed compared to those of tablets. Clockwise hysteresis relationships between the urine flow rate and plasm concentration or urinary excretion rate of BN were observed after administration of retarded capsules. From these studies, retarded capsules of BN possessed a mild diuresis and its diuretic effect was maintained for a few hours after administration.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>10220284</pmid><doi>10.1248/bpb.22.275</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Administration, Oral Adult bioavailability Biological and medical sciences Biological Availability bumetanide Bumetanide - pharmacokinetics Bumetanide - pharmacology Capsules clockwise hysteresis Delayed-Action Preparations diuretic effect Diuretics - pharmacokinetics Diuretics - pharmacology Humans Male Medical sciences Pharmacology. Drug treatments Reference Values retarded capsule tablet Tablets Urinary system |
title | Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects |
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