Evolution of semen quality in North-eastern Spain: a study in 22 759 infertile men over a 36 year period
A retrospective study was conducted in a large population to determine whether sperm quality has changed in North-eastern Spain between 1960 and 1996. From a total initial population of 22 759 men, two separate groups were studied: men with spermatozoa (n = 20 411) and those with azoospermia (n = 13...
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| Veröffentlicht in: | Human reproduction (Oxford) 1999-03, Vol.14 (3), p.731-735 |
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| creator | Andolz, P. Bielsa, M.A. Vila, J. |
| description | A retrospective study was conducted in a large population to determine whether sperm quality has changed in North-eastern Spain between 1960 and 1996. From a total initial population of 22 759 men, two separate groups were studied: men with spermatozoa (n = 20 411) and those with azoospermia (n = 1364). After adjustment for age and sexual abstinence, multiple linear regression analyses were used to assess changes in semen parameters over time. A 0.2% decline was observed in semen volume in the spermatozoa group (P < 0.001). No significant increase (0.04%) in sperm count (× 106/ml) was observed in the spermatozoa group. There was a 0.4% increase in motile spermatozoa in the spermatozoa group (P < 0.001). There was a statistically significant decline in normal spermatozoa (3.6%) in the spermatozoa group (P < 0.001). Of the total population, 1364 men had azoospermia (6.0%). The changes observed in the semen parameters analysed in this large population showed no evidence of a deteriorating sperm quality, although a statistically significant decline was observed in the percentage of normal spermatozoa. |
| doi_str_mv | 10.1093/humrep/14.3.731 |
| format | Article |
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From a total initial population of 22 759 men, two separate groups were studied: men with spermatozoa (n = 20 411) and those with azoospermia (n = 1364). After adjustment for age and sexual abstinence, multiple linear regression analyses were used to assess changes in semen parameters over time. A 0.2% decline was observed in semen volume in the spermatozoa group (P < 0.001). No significant increase (0.04%) in sperm count (× 106/ml) was observed in the spermatozoa group. There was a 0.4% increase in motile spermatozoa in the spermatozoa group (P < 0.001). There was a statistically significant decline in normal spermatozoa (3.6%) in the spermatozoa group (P < 0.001). Of the total population, 1364 men had azoospermia (6.0%). The changes observed in the semen parameters analysed in this large population showed no evidence of a deteriorating sperm quality, although a statistically significant decline was observed in the percentage of normal spermatozoa.</description><identifier>ISSN: 0268-1161</identifier><identifier>ISSN: 1460-2350</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/14.3.731</identifier><identifier>PMID: 10221705</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Aging ; Biological and medical sciences ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Male - pathology ; Infertility, Male - physiopathology ; Linear Models ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Non tumoral diseases ; Oligospermia - pathology ; Oligospermia - physiopathology ; Semen - physiology ; Spain ; Sperm Count ; Sperm Motility</subject><ispartof>Human reproduction (Oxford), 1999-03, Vol.14 (3), p.731-735</ispartof><rights>European Society of Human Reproduction and Embryology 1999</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Mar 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-a1aed321fba93a80879d443a424790d5c2354dd3f2d539ae08a0a915e9dfce533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1756136$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10221705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andolz, P.</creatorcontrib><creatorcontrib>Bielsa, M.A.</creatorcontrib><creatorcontrib>Vila, J.</creatorcontrib><title>Evolution of semen quality in North-eastern Spain: a study in 22 759 infertile men over a 36 year period</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum Reprod</addtitle><description>A retrospective study was conducted in a large population to determine whether sperm quality has changed in North-eastern Spain between 1960 and 1996. From a total initial population of 22 759 men, two separate groups were studied: men with spermatozoa (n = 20 411) and those with azoospermia (n = 1364). After adjustment for age and sexual abstinence, multiple linear regression analyses were used to assess changes in semen parameters over time. A 0.2% decline was observed in semen volume in the spermatozoa group (P < 0.001). No significant increase (0.04%) in sperm count (× 106/ml) was observed in the spermatozoa group. There was a 0.4% increase in motile spermatozoa in the spermatozoa group (P < 0.001). There was a statistically significant decline in normal spermatozoa (3.6%) in the spermatozoa group (P < 0.001). Of the total population, 1364 men had azoospermia (6.0%). The changes observed in the semen parameters analysed in this large population showed no evidence of a deteriorating sperm quality, although a statistically significant decline was observed in the percentage of normal spermatozoa.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility, Male - pathology</subject><subject>Infertility, Male - physiopathology</subject><subject>Linear Models</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Oligospermia - pathology</subject><subject>Oligospermia - physiopathology</subject><subject>Semen - physiology</subject><subject>Spain</subject><subject>Sperm Count</subject><subject>Sperm Motility</subject><issn>0268-1161</issn><issn>1460-2350</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhzA1ZCHFAyq7HH0nMDVWFIlXtAThb03iidZXEqZ1U2n9PlqwE4tLTjDTPvPPxMvYWxBaEVbv93Ccad6C3alspeMY2oEtRSGXEc7YRsqwLgBLO2Kuc74VY0rp8yc5ASAmVMBu2v3yM3TyFOPDY8kw9Dfxhxi5MBx4GfhPTtC8I80Rp4D9GDMNnjjxPs_9Tl5JXxi5ZS2kKHfFjf3yktECq5AfCxEdKIfrX7EWLXaY3p3jOfn29_HlxVVzffvt-8eW6aFStpwIBySsJ7R1ahbWoK-u1VqilrqzwpllO096rVnqjLJKoUaAFQ9a3DRmlztnHVXdM8WGmPLk-5Ia6DgeKc3alrcDqslzA9_-B93FOw7KbkwBWmEoe1XYr1KSYc6LWjSn0mA4OhDs64FYHHGin3OLA0vHuJDvf9eT_4deXL8CHE4C5wa5NODQh_-UqU4I6rvdpxeI8Pjn0N488m6I</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Andolz, P.</creator><creator>Bielsa, M.A.</creator><creator>Vila, J.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Evolution of semen quality in North-eastern Spain: a study in 22 759 infertile men over a 36 year period</title><author>Andolz, P. ; Bielsa, M.A. ; Vila, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-a1aed321fba93a80879d443a424790d5c2354dd3f2d539ae08a0a915e9dfce533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility, Male - pathology</topic><topic>Infertility, Male - physiopathology</topic><topic>Linear Models</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Oligospermia - pathology</topic><topic>Oligospermia - physiopathology</topic><topic>Semen - physiology</topic><topic>Spain</topic><topic>Sperm Count</topic><topic>Sperm Motility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andolz, P.</creatorcontrib><creatorcontrib>Bielsa, M.A.</creatorcontrib><creatorcontrib>Vila, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andolz, P.</au><au>Bielsa, M.A.</au><au>Vila, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution of semen quality in North-eastern Spain: a study in 22 759 infertile men over a 36 year period</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum Reprod</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>14</volume><issue>3</issue><spage>731</spage><epage>735</epage><pages>731-735</pages><issn>0268-1161</issn><issn>1460-2350</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>A retrospective study was conducted in a large population to determine whether sperm quality has changed in North-eastern Spain between 1960 and 1996. From a total initial population of 22 759 men, two separate groups were studied: men with spermatozoa (n = 20 411) and those with azoospermia (n = 1364). After adjustment for age and sexual abstinence, multiple linear regression analyses were used to assess changes in semen parameters over time. A 0.2% decline was observed in semen volume in the spermatozoa group (P < 0.001). No significant increase (0.04%) in sperm count (× 106/ml) was observed in the spermatozoa group. There was a 0.4% increase in motile spermatozoa in the spermatozoa group (P < 0.001). There was a statistically significant decline in normal spermatozoa (3.6%) in the spermatozoa group (P < 0.001). Of the total population, 1364 men had azoospermia (6.0%). The changes observed in the semen parameters analysed in this large population showed no evidence of a deteriorating sperm quality, although a statistically significant decline was observed in the percentage of normal spermatozoa.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10221705</pmid><doi>10.1093/humrep/14.3.731</doi><tpages>5</tpages></addata></record> |
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| ispartof | Human reproduction (Oxford), 1999-03, Vol.14 (3), p.731-735 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aging Biological and medical sciences Gynecology. Andrology. Obstetrics Humans Infertility, Male - pathology Infertility, Male - physiopathology Linear Models Male Male genital diseases Medical sciences Middle Aged Non tumoral diseases Oligospermia - pathology Oligospermia - physiopathology Semen - physiology Spain Sperm Count Sperm Motility |
| title | Evolution of semen quality in North-eastern Spain: a study in 22 759 infertile men over a 36 year period |
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