The rewarding efficacy of brain stimulation and its modulation by dopaminergic drugs in young adult and old BN F344F1 rats

In old age there is evidence of waning motivation, and possibly lowering of mood. Physiologically there is a decline in the levels of brain neurotransmitters such as acetylcholine and dopamine, and loss of myelin. These changes might be expected to impair the functioning of brain circuitry for reinf...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2008-10, Vol.90 (4), p.735-741
Hauptverfasser:	Sonnenschein, Bonnie, Franklin, Keith B.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Aging - psychology Alpha-methyl- p-tyrosine alpha-Methyltyrosine - pharmacology Amphetamine Animals Biological and medical sciences Brain - physiology Brain Chemistry - drug effects Conditioning, Operant - drug effects Conditioning, Operant - physiology Dextroamphetamine - pharmacology Dopamine Dopamine Agents - pharmacology Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Electric Stimulation Enzyme Inhibitors - pharmacology Medical sciences Rate-frequency curve Rats Rats, Inbred F344 Reinforcement Reinforcement Schedule Reward Rewarding brain stimulation
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