Matrix Metalloproteinases and Lysosomal Cysteine Proteases in Osteoclasts Contribute to Bone Resorption through Distinct Modes of Action

The effects of inhibitors of matrix metalloproteinases (MMPs) and lysosomal cysteine proteases on osteoclastic pit formation in dentine slices were investigated. A nonspecific cysteine protease inhibitor, E-64, inhibited pit formation on naked slices in a concentration-dependent manner, and at 10 μM...

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Veröffentlicht in:	Biochemical and biophysical research communications 1999-04, Vol.258 (1), p.173-178
Hauptverfasser:	Inui, Takashi, Ishibashi, Osamu, Origane, Yumi, Fujimori, Ko, Kokubo, Toshio, Nakajima, Motowo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Bone Resorption Cysteine Endopeptidases - metabolism DNA Primers Leucine - analogs & derivatives Leucine - pharmacology Lysosomes - enzymology Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - metabolism Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - enzymology Phenylalanine - analogs & derivatives Phenylalanine - pharmacology Protease Inhibitors - pharmacology Rabbits Reverse Transcriptase Polymerase Chain Reaction Thiophenes - pharmacology
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