Treatment of cancer of the exocrine pancreas
Background: The incidence of cancer of the exocrine pancreas varies among populations, being the fourth or fifth cause of cancer death in the West. Outcome remains poor and opinions remain divided over the optimal management of the condition. Method: A computer literature search was made of the MEDL...
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| Veröffentlicht in: | The American Journal of Surgery 1999-03, Vol.177 (3), p.257-265 |
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| creator | Huguier, Michel Mason, Nicholas P |
| description | Background: The incidence of cancer of the exocrine pancreas varies among populations, being the fourth or fifth cause of cancer death in the West. Outcome remains poor and opinions remain divided over the optimal management of the condition.
Method: A computer literature search was made of the MEDLINE database from January 1990 to December 1997 and selected other studies.
Results: Indications and contraindications for surgery, indications for stenting, indications for resection, the technique of palliative procedures and of resection, chemotherapy, radiotherapy, and combined treatments and other treatments are discussed and recommendations made.
Conclusions: Irrespective of tumor size or spread, resection if feasible gives the best survival rates. Careful patient selection is required, however, to exclude those patients for whom surgical resection has no benefit. Nonsurgical procedures including endoscopic stenting in patients with high operative risk or short survival expectancy can significantly improve quality of life. The place of adjuvant therapies remains controversial and further controlled trials are required to demonstrate their efficacy. |
| doi_str_mv | 10.1016/S0002-9610(99)00003-3 |
| format | Article |
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Method: A computer literature search was made of the MEDLINE database from January 1990 to December 1997 and selected other studies.
Results: Indications and contraindications for surgery, indications for stenting, indications for resection, the technique of palliative procedures and of resection, chemotherapy, radiotherapy, and combined treatments and other treatments are discussed and recommendations made.
Conclusions: Irrespective of tumor size or spread, resection if feasible gives the best survival rates. Careful patient selection is required, however, to exclude those patients for whom surgical resection has no benefit. Nonsurgical procedures including endoscopic stenting in patients with high operative risk or short survival expectancy can significantly improve quality of life. The place of adjuvant therapies remains controversial and further controlled trials are required to demonstrate their efficacy.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(99)00003-3</identifier><identifier>PMID: 10219866</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - therapy ; Aged ; Biological and medical sciences ; Cancer ; Chemotherapy ; Clinical trials ; Combined Modality Therapy ; Databases as Topic - statistics & numerical data ; Decision Making ; Endoscopy ; Expectancy ; Feasibility Studies ; Fistula ; Gallbladder ; Gastroenterology. Liver. Pancreas. Abdomen ; Hospitals ; Humans ; Life expectancy ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymphatic system ; Medical sciences ; Metastasis ; Mortality ; Palliative Care ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - therapy ; Patients ; Quality of life ; Radiation therapy ; Randomized Controlled Trials as Topic ; Regression analysis ; Retrospective Studies ; Sepsis ; Surgery ; Surgical anastomosis ; Survival ; Survival Rate ; Treatment Outcome ; Tumors</subject><ispartof>The American Journal of Surgery, 1999-03, Vol.177 (3), p.257-265</ispartof><rights>1999 Excerpta Medica Inc.</rights><rights>1999 INIST-CNRS</rights><rights>1999. Excerpta Medica Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-8b1779e6e1948aa3496b75b4e046a7da4201301287aaf9fee442f21186e959d53</citedby><cites>FETCH-LOGICAL-c418t-8b1779e6e1948aa3496b75b4e046a7da4201301287aaf9fee442f21186e959d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002961099000033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3537,27899,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1758435$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10219866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huguier, Michel</creatorcontrib><creatorcontrib>Mason, Nicholas P</creatorcontrib><title>Treatment of cancer of the exocrine pancreas</title><title>The American Journal of Surgery</title><addtitle>Am J Surg</addtitle><description>Background: The incidence of cancer of the exocrine pancreas varies among populations, being the fourth or fifth cause of cancer death in the West. Outcome remains poor and opinions remain divided over the optimal management of the condition.
Method: A computer literature search was made of the MEDLINE database from January 1990 to December 1997 and selected other studies.
Results: Indications and contraindications for surgery, indications for stenting, indications for resection, the technique of palliative procedures and of resection, chemotherapy, radiotherapy, and combined treatments and other treatments are discussed and recommendations made.
Conclusions: Irrespective of tumor size or spread, resection if feasible gives the best survival rates. Careful patient selection is required, however, to exclude those patients for whom surgical resection has no benefit. Nonsurgical procedures including endoscopic stenting in patients with high operative risk or short survival expectancy can significantly improve quality of life. The place of adjuvant therapies remains controversial and further controlled trials are required to demonstrate their efficacy.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - therapy</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Combined Modality Therapy</subject><subject>Databases as Topic - statistics & numerical data</subject><subject>Decision Making</subject><subject>Endoscopy</subject><subject>Expectancy</subject><subject>Feasibility Studies</subject><subject>Fistula</subject><subject>Gallbladder</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Life expectancy</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lymphatic system</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Palliative Care</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - therapy</subject><subject>Patients</subject><subject>Quality of life</subject><subject>Radiation therapy</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Sepsis</subject><subject>Surgery</subject><subject>Surgical anastomosis</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkEtLAzEQgIMotlZ_glJQRMHVzCabx0mk-IKCB-s5ZLOzuKXdrclW9N-bdouKF0_z4Jth5iPkEOglUBBXz5TSNNEC6JnW57GgLGFbpA9K6gSUYtuk_430yF4I01gCcLZLekBT0EqIPrmYeLTtHOt22JRDZ2uHfpW1rzjEj8b5qsbhIrYjFvbJTmlnAQ82cUBe7m4no4dk_HT_OLoZJ46DahOVg5QaBYLmylrGtchllnOkXFhZWJ5SYBRSJa0tdYnIeVqmAEqgznSRsQE57fYufPO2xNCaeRUczma2xmYZjNASpBZpBI__gNNm6et4m0kVl5xrYBCprKOcb0LwWJqFr-bWfxqgZiXTrGWalSmjtVnLNCzOHW22L_M5Fr-mOnsRONkANjg7K330VIUfTmaKs9U71x2G0dl7hd4EV2E0XVQeXWuKpvrnki-sHY0Q</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Huguier, Michel</creator><creator>Mason, Nicholas P</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Treatment of cancer of the exocrine pancreas</title><author>Huguier, Michel ; Mason, Nicholas P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-8b1779e6e1948aa3496b75b4e046a7da4201301287aaf9fee442f21186e959d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - therapy</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Combined Modality Therapy</topic><topic>Databases as Topic - statistics & numerical data</topic><topic>Decision Making</topic><topic>Endoscopy</topic><topic>Expectancy</topic><topic>Feasibility Studies</topic><topic>Fistula</topic><topic>Gallbladder</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Life expectancy</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lymphatic system</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Mortality</topic><topic>Palliative Care</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - therapy</topic><topic>Patients</topic><topic>Quality of life</topic><topic>Radiation therapy</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Sepsis</topic><topic>Surgery</topic><topic>Surgical anastomosis</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huguier, Michel</creatorcontrib><creatorcontrib>Mason, Nicholas P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American Journal of Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huguier, Michel</au><au>Mason, Nicholas P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of cancer of the exocrine pancreas</atitle><jtitle>The American Journal of Surgery</jtitle><addtitle>Am J Surg</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>177</volume><issue>3</issue><spage>257</spage><epage>265</epage><pages>257-265</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Background: The incidence of cancer of the exocrine pancreas varies among populations, being the fourth or fifth cause of cancer death in the West. Outcome remains poor and opinions remain divided over the optimal management of the condition.
Method: A computer literature search was made of the MEDLINE database from January 1990 to December 1997 and selected other studies.
Results: Indications and contraindications for surgery, indications for stenting, indications for resection, the technique of palliative procedures and of resection, chemotherapy, radiotherapy, and combined treatments and other treatments are discussed and recommendations made.
Conclusions: Irrespective of tumor size or spread, resection if feasible gives the best survival rates. Careful patient selection is required, however, to exclude those patients for whom surgical resection has no benefit. Nonsurgical procedures including endoscopic stenting in patients with high operative risk or short survival expectancy can significantly improve quality of life. The place of adjuvant therapies remains controversial and further controlled trials are required to demonstrate their efficacy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10219866</pmid><doi>10.1016/S0002-9610(99)00003-3</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy Aged Biological and medical sciences Cancer Chemotherapy Clinical trials Combined Modality Therapy Databases as Topic - statistics & numerical data Decision Making Endoscopy Expectancy Feasibility Studies Fistula Gallbladder Gastroenterology. Liver. Pancreas. Abdomen Hospitals Humans Life expectancy Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphatic system Medical sciences Metastasis Mortality Palliative Care Pancreas Pancreatic cancer Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Patients Quality of life Radiation therapy Randomized Controlled Trials as Topic Regression analysis Retrospective Studies Sepsis Surgery Surgical anastomosis Survival Survival Rate Treatment Outcome Tumors |
| title | Treatment of cancer of the exocrine pancreas |
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