Spinal nerve ligation reduces nitric oxide synthase activity and expression: Effect of resveratrol

The effect of resveratrol on activity and expression of nitric oxide synthase (NOS) in the spinal cord of neuropathic rats was assessed. Spinal nerve ligation produced tactile allodynia along with a reduction of catalytic activity of the constitutive Ca 2+-dependent NOS (eNOS and nNOS isoforms) in t...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2008-10, Vol.90 (4), p.742-747
Hauptverfasser:	PEREZSEVERIANO, F, BERMUDEZOCANA, D, LOPEZSANCHEZ, P, RIOS, C, GRANADOSSOTO, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - pharmacology Animals Antioxidants - administration & dosage Antioxidants - pharmacology Biological and medical sciences Female Injections, Spinal Ligation Medical sciences Neuropathic pain Nitric Oxide - physiology Nitric Oxide Synthase Type I - biosynthesis nNOS expression NOS activity Pain Measurement - drug effects Physical Stimulation Rats Rats, Wistar Resveratrol Spinal Cord - drug effects Spinal Cord - enzymology Spinal Nerves - physiology Stilbenes - administration & dosage Stilbenes - pharmacology Tactile allodynia
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