Spinal nerve ligation reduces nitric oxide synthase activity and expression: Effect of resveratrol
The effect of resveratrol on activity and expression of nitric oxide synthase (NOS) in the spinal cord of neuropathic rats was assessed. Spinal nerve ligation produced tactile allodynia along with a reduction of catalytic activity of the constitutive Ca 2+-dependent NOS (eNOS and nNOS isoforms) in t...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2008-10, Vol.90 (4), p.742-747 |
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| creator | PEREZSEVERIANO, F BERMUDEZOCANA, D LOPEZSANCHEZ, P RIOS, C GRANADOSSOTO, V |
| description | The effect of resveratrol on activity and expression of nitric oxide synthase (NOS) in the spinal cord of neuropathic rats was assessed. Spinal nerve ligation produced tactile allodynia along with a reduction of catalytic activity of the constitutive Ca
2+-dependent NOS (eNOS and nNOS isoforms) in the ipsilateral dorsal horn, but not contralateral dorsal or ipsilateral or contralateral ventral, spinal cord at 1, 5, 10 and 15 days after surgery compared to naïve and sham-operated animals. Nerve ligation also induced a reduction of nNOS expression in the ipsilateral dorsal horn spinal cord at 10 and 15 days after surgery. Intrathecal resveratrol reduced allodynia and reversed the reduction of constitutive Ca
2+-dependent NOS activity in the ipsilateral dorsal spinal cord. Moreover, resveratrol significantly reversed the reduction of nNOS expression in the ipsilateral dorsal horn spinal cord. Results show that spinal nerve ligation leads to development of tactile allodynia along with a reduction in constitutive Ca
2+-dependent NOS activity and nNOS isoform expression in the ipsilateral dorsal horn. Data suggest that resveratrol may reduce tactile allodynia in neuropathic rats by restoring altered NOS activity and expression. |
| doi_str_mv | 10.1016/j.pbb.2008.05.024 |
| format | Article |
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2+-dependent NOS (eNOS and nNOS isoforms) in the ipsilateral dorsal horn, but not contralateral dorsal or ipsilateral or contralateral ventral, spinal cord at 1, 5, 10 and 15 days after surgery compared to naïve and sham-operated animals. Nerve ligation also induced a reduction of nNOS expression in the ipsilateral dorsal horn spinal cord at 10 and 15 days after surgery. Intrathecal resveratrol reduced allodynia and reversed the reduction of constitutive Ca
2+-dependent NOS activity in the ipsilateral dorsal spinal cord. Moreover, resveratrol significantly reversed the reduction of nNOS expression in the ipsilateral dorsal horn spinal cord. Results show that spinal nerve ligation leads to development of tactile allodynia along with a reduction in constitutive Ca
2+-dependent NOS activity and nNOS isoform expression in the ipsilateral dorsal horn. Data suggest that resveratrol may reduce tactile allodynia in neuropathic rats by restoring altered NOS activity and expression.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/j.pbb.2008.05.024</identifier><identifier>PMID: 18582495</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Actins - pharmacology ; Animals ; Antioxidants - administration & dosage ; Antioxidants - pharmacology ; Biological and medical sciences ; Female ; Injections, Spinal ; Ligation ; Medical sciences ; Neuropathic pain ; Nitric Oxide - physiology ; Nitric Oxide Synthase Type I - biosynthesis ; nNOS expression ; NOS activity ; Pain Measurement - drug effects ; Physical Stimulation ; Rats ; Rats, Wistar ; Resveratrol ; Spinal Cord - drug effects ; Spinal Cord - enzymology ; Spinal Nerves - physiology ; Stilbenes - administration & dosage ; Stilbenes - pharmacology ; Tactile allodynia</subject><ispartof>Pharmacology, biochemistry and behavior, 2008-10, Vol.90 (4), p.742-747</ispartof><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-9b9aa6ff43d23691d588988a290a0dc31ea67d48e4fd8ea9ef48e017a1cf1e343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pbb.2008.05.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20572493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18582495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PEREZSEVERIANO, F</creatorcontrib><creatorcontrib>BERMUDEZOCANA, D</creatorcontrib><creatorcontrib>LOPEZSANCHEZ, P</creatorcontrib><creatorcontrib>RIOS, C</creatorcontrib><creatorcontrib>GRANADOSSOTO, V</creatorcontrib><title>Spinal nerve ligation reduces nitric oxide synthase activity and expression: Effect of resveratrol</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The effect of resveratrol on activity and expression of nitric oxide synthase (NOS) in the spinal cord of neuropathic rats was assessed. Spinal nerve ligation produced tactile allodynia along with a reduction of catalytic activity of the constitutive Ca
2+-dependent NOS (eNOS and nNOS isoforms) in the ipsilateral dorsal horn, but not contralateral dorsal or ipsilateral or contralateral ventral, spinal cord at 1, 5, 10 and 15 days after surgery compared to naïve and sham-operated animals. Nerve ligation also induced a reduction of nNOS expression in the ipsilateral dorsal horn spinal cord at 10 and 15 days after surgery. Intrathecal resveratrol reduced allodynia and reversed the reduction of constitutive Ca
2+-dependent NOS activity in the ipsilateral dorsal spinal cord. Moreover, resveratrol significantly reversed the reduction of nNOS expression in the ipsilateral dorsal horn spinal cord. Results show that spinal nerve ligation leads to development of tactile allodynia along with a reduction in constitutive Ca
2+-dependent NOS activity and nNOS isoform expression in the ipsilateral dorsal horn. Data suggest that resveratrol may reduce tactile allodynia in neuropathic rats by restoring altered NOS activity and expression.</description><subject>Actins - pharmacology</subject><subject>Animals</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Injections, Spinal</subject><subject>Ligation</subject><subject>Medical sciences</subject><subject>Neuropathic pain</subject><subject>Nitric Oxide - physiology</subject><subject>Nitric Oxide Synthase Type I - biosynthesis</subject><subject>nNOS expression</subject><subject>NOS activity</subject><subject>Pain Measurement - drug effects</subject><subject>Physical Stimulation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Resveratrol</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - enzymology</subject><subject>Spinal Nerves - physiology</subject><subject>Stilbenes - administration & dosage</subject><subject>Stilbenes - pharmacology</subject><subject>Tactile allodynia</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EokPhA9ggb2CXYMdJbMOqqkpBqsQCWFsv9jN4lHGC7Rl1_h5XM4JdWfktzr2y7iHkNWctZ3x8v23XaWo7xlTLhpZ1_ROy4UqKZuBSPiUbxjRvBBvkBXmR85Yx1nejfE4uuBpU1-thQ6Zva4gw04jpgHQOP6GEJdKEbm8x0xhKCpYu98EhzcdYfkFGCraEQyhHCtFRvF8T5lxTH-iN92gLXXwtyAdMUNIyvyTPPMwZX53fS_Lj083368_N3dfbL9dXd43teVcaPWmA0fteuE6MmrtBKa0UdJoBc1ZwhFG6XmHvnULQ6OvNuARuPUfRi0vy7tS7puX3HnMxu5AtzjNEXPbZjFpyOWr1X5DrgTMhxwryE2jTknNCb9YUdpCOhjPzYMBsTTVgHgwYNphqoGbenMv30w7dv8R58gq8PQOQLcw-QbQh_-W6qqtyonIfTxzWzQ4Bk8k2YLToQqojG7eER77xB6BppPU</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>PEREZSEVERIANO, F</creator><creator>BERMUDEZOCANA, D</creator><creator>LOPEZSANCHEZ, P</creator><creator>RIOS, C</creator><creator>GRANADOSSOTO, V</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Spinal nerve ligation reduces nitric oxide synthase activity and expression: Effect of resveratrol</title><author>PEREZSEVERIANO, F ; BERMUDEZOCANA, D ; LOPEZSANCHEZ, P ; RIOS, C ; GRANADOSSOTO, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-9b9aa6ff43d23691d588988a290a0dc31ea67d48e4fd8ea9ef48e017a1cf1e343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Actins - pharmacology</topic><topic>Animals</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Injections, Spinal</topic><topic>Ligation</topic><topic>Medical sciences</topic><topic>Neuropathic pain</topic><topic>Nitric Oxide - physiology</topic><topic>Nitric Oxide Synthase Type I - biosynthesis</topic><topic>nNOS expression</topic><topic>NOS activity</topic><topic>Pain Measurement - drug effects</topic><topic>Physical Stimulation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Resveratrol</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - enzymology</topic><topic>Spinal Nerves - physiology</topic><topic>Stilbenes - administration & dosage</topic><topic>Stilbenes - pharmacology</topic><topic>Tactile allodynia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PEREZSEVERIANO, F</creatorcontrib><creatorcontrib>BERMUDEZOCANA, D</creatorcontrib><creatorcontrib>LOPEZSANCHEZ, P</creatorcontrib><creatorcontrib>RIOS, C</creatorcontrib><creatorcontrib>GRANADOSSOTO, V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PEREZSEVERIANO, F</au><au>BERMUDEZOCANA, D</au><au>LOPEZSANCHEZ, P</au><au>RIOS, C</au><au>GRANADOSSOTO, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spinal nerve ligation reduces nitric oxide synthase activity and expression: Effect of resveratrol</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>90</volume><issue>4</issue><spage>742</spage><epage>747</epage><pages>742-747</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The effect of resveratrol on activity and expression of nitric oxide synthase (NOS) in the spinal cord of neuropathic rats was assessed. Spinal nerve ligation produced tactile allodynia along with a reduction of catalytic activity of the constitutive Ca
2+-dependent NOS (eNOS and nNOS isoforms) in the ipsilateral dorsal horn, but not contralateral dorsal or ipsilateral or contralateral ventral, spinal cord at 1, 5, 10 and 15 days after surgery compared to naïve and sham-operated animals. Nerve ligation also induced a reduction of nNOS expression in the ipsilateral dorsal horn spinal cord at 10 and 15 days after surgery. Intrathecal resveratrol reduced allodynia and reversed the reduction of constitutive Ca
2+-dependent NOS activity in the ipsilateral dorsal spinal cord. Moreover, resveratrol significantly reversed the reduction of nNOS expression in the ipsilateral dorsal horn spinal cord. Results show that spinal nerve ligation leads to development of tactile allodynia along with a reduction in constitutive Ca
2+-dependent NOS activity and nNOS isoform expression in the ipsilateral dorsal horn. Data suggest that resveratrol may reduce tactile allodynia in neuropathic rats by restoring altered NOS activity and expression.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18582495</pmid><doi>10.1016/j.pbb.2008.05.024</doi><tpages>6</tpages></addata></record> |
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| subjects | Actins - pharmacology Animals Antioxidants - administration & dosage Antioxidants - pharmacology Biological and medical sciences Female Injections, Spinal Ligation Medical sciences Neuropathic pain Nitric Oxide - physiology Nitric Oxide Synthase Type I - biosynthesis nNOS expression NOS activity Pain Measurement - drug effects Physical Stimulation Rats Rats, Wistar Resveratrol Spinal Cord - drug effects Spinal Cord - enzymology Spinal Nerves - physiology Stilbenes - administration & dosage Stilbenes - pharmacology Tactile allodynia |
| title | Spinal nerve ligation reduces nitric oxide synthase activity and expression: Effect of resveratrol |
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