Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation
Trace element external quality assessment schemes monitor laboratory performance and provide a stimulus for improvement in accuracy. However, monitoring of participant performance varies according to the scheme and can lead to conflicting conclusions. Quality specifications based on biological intra...
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 2008-11, Vol.54 (11), p.1892-1899 |
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| container_title | Clinical chemistry (Baltimore, Md.) |
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| creator | Arnaud, Josiane Weber, Jean-Philippe Weykamp, Cas W Parsons, Patrick J Angerer, Jurgen Mairiaux, Eric Mazarrasa, Olav Valkonen, Sinikka Menditto, Antonio Patriarca, Marina Taylor, Andrew |
| description | Trace element external quality assessment schemes monitor laboratory performance and provide a stimulus for improvement in accuracy. However, monitoring of participant performance varies according to the scheme and can lead to conflicting conclusions.
Quality specifications based on biological intra- and interindividual variability were calculated and compared to those currently used by various trace element external quality assessment schemes for plasma or serum copper, zinc, and selenium concentrations. For this purpose, we evaluated results reported by participating laboratories in different schemes, at key concentrations, using z scores.
Minimal quality specifications developed from the biological intra- and interindividual variability were, for Cu, +/-0.84 micromol/L or 12% of the assigned target concentration, whichever is greater; for Zn, +/-1.20 micromol/L or 15% of the assigned target concentration, whichever is greater; and for Se, +/-0.072 micromol/L or 12% of the assigned target concentration, whichever is greater. Reported performance of the participating laboratories depended on analyte, concentration, and the selected quality specification. In addition, the most commonly used methods for the determination of Cu, Zn, and Se may give different results.
The proposed minimal quality specifications based on biological variation are generally slightly less stringent than those currently in use, although they do not drastically change the performance evaluation in the different schemes. These specifications are a first step in the harmonization of practices among the schemes and remain to be evaluated. |
| doi_str_mv | 10.1373/clinchem.2008.108142 |
| format | Article |
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Quality specifications based on biological intra- and interindividual variability were calculated and compared to those currently used by various trace element external quality assessment schemes for plasma or serum copper, zinc, and selenium concentrations. For this purpose, we evaluated results reported by participating laboratories in different schemes, at key concentrations, using z scores.
Minimal quality specifications developed from the biological intra- and interindividual variability were, for Cu, +/-0.84 micromol/L or 12% of the assigned target concentration, whichever is greater; for Zn, +/-1.20 micromol/L or 15% of the assigned target concentration, whichever is greater; and for Se, +/-0.072 micromol/L or 12% of the assigned target concentration, whichever is greater. Reported performance of the participating laboratories depended on analyte, concentration, and the selected quality specification. In addition, the most commonly used methods for the determination of Cu, Zn, and Se may give different results.
The proposed minimal quality specifications based on biological variation are generally slightly less stringent than those currently in use, although they do not drastically change the performance evaluation in the different schemes. These specifications are a first step in the harmonization of practices among the schemes and remain to be evaluated.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1373/clinchem.2008.108142</identifier><identifier>PMID: 18719198</identifier><identifier>CODEN: CLCHAU</identifier><language>eng</language><publisher>Washington, DC: Am Assoc Clin Chem</publisher><subject>Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Clinical medicine ; Copper ; Copper - blood ; Environmental health ; Fundamental and applied biological sciences. Psychology ; Genetic disorders ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Laboratories ; Medical sciences ; Methods ; Plasma ; Quality Control ; Reproducibility of Results ; Selenium ; Selenium - blood ; Specifications ; Spectrophotometry, Atomic - methods ; Spectrophotometry, Atomic - standards ; Trace elements ; Zinc - blood</subject><ispartof>Clinical chemistry (Baltimore, Md.), 2008-11, Vol.54 (11), p.1892-1899</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright American Association for Clinical Chemistry Nov 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-61dcbf22d058b8a97b5730a8347d3bdf3567aabd12112aff014556ec423959e3</citedby><cites>FETCH-LOGICAL-c440t-61dcbf22d058b8a97b5730a8347d3bdf3567aabd12112aff014556ec423959e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20818811$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18719198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arnaud, Josiane</creatorcontrib><creatorcontrib>Weber, Jean-Philippe</creatorcontrib><creatorcontrib>Weykamp, Cas W</creatorcontrib><creatorcontrib>Parsons, Patrick J</creatorcontrib><creatorcontrib>Angerer, Jurgen</creatorcontrib><creatorcontrib>Mairiaux, Eric</creatorcontrib><creatorcontrib>Mazarrasa, Olav</creatorcontrib><creatorcontrib>Valkonen, Sinikka</creatorcontrib><creatorcontrib>Menditto, Antonio</creatorcontrib><creatorcontrib>Patriarca, Marina</creatorcontrib><creatorcontrib>Taylor, Andrew</creatorcontrib><title>Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>Trace element external quality assessment schemes monitor laboratory performance and provide a stimulus for improvement in accuracy. However, monitoring of participant performance varies according to the scheme and can lead to conflicting conclusions.
Quality specifications based on biological intra- and interindividual variability were calculated and compared to those currently used by various trace element external quality assessment schemes for plasma or serum copper, zinc, and selenium concentrations. For this purpose, we evaluated results reported by participating laboratories in different schemes, at key concentrations, using z scores.
Minimal quality specifications developed from the biological intra- and interindividual variability were, for Cu, +/-0.84 micromol/L or 12% of the assigned target concentration, whichever is greater; for Zn, +/-1.20 micromol/L or 15% of the assigned target concentration, whichever is greater; and for Se, +/-0.072 micromol/L or 12% of the assigned target concentration, whichever is greater. Reported performance of the participating laboratories depended on analyte, concentration, and the selected quality specification. In addition, the most commonly used methods for the determination of Cu, Zn, and Se may give different results.
The proposed minimal quality specifications based on biological variation are generally slightly less stringent than those currently in use, although they do not drastically change the performance evaluation in the different schemes. These specifications are a first step in the harmonization of practices among the schemes and remain to be evaluated.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Clinical medicine</subject><subject>Copper</subject><subject>Copper - blood</subject><subject>Environmental health</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic disorders</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laboratories</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Plasma</subject><subject>Quality Control</subject><subject>Reproducibility of Results</subject><subject>Selenium</subject><subject>Selenium - blood</subject><subject>Specifications</subject><subject>Spectrophotometry, Atomic - methods</subject><subject>Spectrophotometry, Atomic - standards</subject><subject>Trace elements</subject><subject>Zinc - blood</subject><issn>0009-9147</issn><issn>1530-8561</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkdtu1DAQhiMEokvhDRCykICbZvHETmJzt10KRaoEqBUX3FgTx2lcOYfaCat9Jl4S74EicWXN6JtvRv6T5CXQJbCSvdfO9ro13TKjVCyBCuDZo2QBOaOpyAt4nCwopTKVwMuT5FkId7HkpSieJicgSpAgxSL5_X1GZ6ctuR6Nto3VONmhD6QZPJlaQz6ayfjO9vs2GRqyHsbR-DPyM24_I9jX5No409u5I7Ynl3OHfez4WEbDN4ehww_k4he6-UERidU4-gF1S84xmJrE_rkd3HAb97u9dNWj20778gd6u599njxp0AXz4vieJjefLm7Wl-nV189f1qurVHNOp7SAWldNltU0F5VAWVZ5ySgKxsuaVXXD8qJErGrIADJsGgo8zwujecZkLg07Td4etPHE-9mESXU2aOMc9maYgypkCWUuZQRf_wfeDbOPhweVAZOCx1-OED9A2g8heNOo0dsO_VYBVbsg1d8g1S5IdQgyjr06uueqM_W_oWNyEXhzBDDEX2o89tqGBy6LGiFgt__dgWvtbbux3qiYiHNRC2qz2eRcAUSrzNgfUyK3QQ</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Arnaud, Josiane</creator><creator>Weber, Jean-Philippe</creator><creator>Weykamp, Cas W</creator><creator>Parsons, Patrick J</creator><creator>Angerer, Jurgen</creator><creator>Mairiaux, Eric</creator><creator>Mazarrasa, Olav</creator><creator>Valkonen, Sinikka</creator><creator>Menditto, Antonio</creator><creator>Patriarca, Marina</creator><creator>Taylor, Andrew</creator><general>Am Assoc Clin Chem</general><general>American Association for Clinical Chemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7QO</scope><scope>7RV</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation</title><author>Arnaud, Josiane ; Weber, Jean-Philippe ; Weykamp, Cas W ; Parsons, Patrick J ; Angerer, Jurgen ; Mairiaux, Eric ; Mazarrasa, Olav ; Valkonen, Sinikka ; Menditto, Antonio ; Patriarca, Marina ; Taylor, Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-61dcbf22d058b8a97b5730a8347d3bdf3567aabd12112aff014556ec423959e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Clinical medicine</topic><topic>Copper</topic><topic>Copper - blood</topic><topic>Environmental health</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic disorders</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Laboratories</topic><topic>Medical sciences</topic><topic>Methods</topic><topic>Plasma</topic><topic>Quality Control</topic><topic>Reproducibility of Results</topic><topic>Selenium</topic><topic>Selenium - blood</topic><topic>Specifications</topic><topic>Spectrophotometry, Atomic - methods</topic><topic>Spectrophotometry, Atomic - standards</topic><topic>Trace elements</topic><topic>Zinc - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arnaud, Josiane</creatorcontrib><creatorcontrib>Weber, Jean-Philippe</creatorcontrib><creatorcontrib>Weykamp, Cas W</creatorcontrib><creatorcontrib>Parsons, Patrick J</creatorcontrib><creatorcontrib>Angerer, Jurgen</creatorcontrib><creatorcontrib>Mairiaux, Eric</creatorcontrib><creatorcontrib>Mazarrasa, Olav</creatorcontrib><creatorcontrib>Valkonen, Sinikka</creatorcontrib><creatorcontrib>Menditto, Antonio</creatorcontrib><creatorcontrib>Patriarca, Marina</creatorcontrib><creatorcontrib>Taylor, Andrew</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arnaud, Josiane</au><au>Weber, Jean-Philippe</au><au>Weykamp, Cas W</au><au>Parsons, Patrick J</au><au>Angerer, Jurgen</au><au>Mairiaux, Eric</au><au>Mazarrasa, Olav</au><au>Valkonen, Sinikka</au><au>Menditto, Antonio</au><au>Patriarca, Marina</au><au>Taylor, Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>54</volume><issue>11</issue><spage>1892</spage><epage>1899</epage><pages>1892-1899</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><coden>CLCHAU</coden><abstract>Trace element external quality assessment schemes monitor laboratory performance and provide a stimulus for improvement in accuracy. However, monitoring of participant performance varies according to the scheme and can lead to conflicting conclusions.
Quality specifications based on biological intra- and interindividual variability were calculated and compared to those currently used by various trace element external quality assessment schemes for plasma or serum copper, zinc, and selenium concentrations. For this purpose, we evaluated results reported by participating laboratories in different schemes, at key concentrations, using z scores.
Minimal quality specifications developed from the biological intra- and interindividual variability were, for Cu, +/-0.84 micromol/L or 12% of the assigned target concentration, whichever is greater; for Zn, +/-1.20 micromol/L or 15% of the assigned target concentration, whichever is greater; and for Se, +/-0.072 micromol/L or 12% of the assigned target concentration, whichever is greater. Reported performance of the participating laboratories depended on analyte, concentration, and the selected quality specification. In addition, the most commonly used methods for the determination of Cu, Zn, and Se may give different results.
The proposed minimal quality specifications based on biological variation are generally slightly less stringent than those currently in use, although they do not drastically change the performance evaluation in the different schemes. These specifications are a first step in the harmonization of practices among the schemes and remain to be evaluated.</abstract><cop>Washington, DC</cop><pub>Am Assoc Clin Chem</pub><pmid>18719198</pmid><doi>10.1373/clinchem.2008.108142</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analytical, structural and metabolic biochemistry Biological and medical sciences Clinical medicine Copper Copper - blood Environmental health Fundamental and applied biological sciences. Psychology Genetic disorders Humans Investigative techniques, diagnostic techniques (general aspects) Laboratories Medical sciences Methods Plasma Quality Control Reproducibility of Results Selenium Selenium - blood Specifications Spectrophotometry, Atomic - methods Spectrophotometry, Atomic - standards Trace elements Zinc - blood |
| title | Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation |
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