Hammerhead Ribozyme-Mediated Cleavage of the Human Insulin-Like Growth Factor-II Ribonucleic Acid in Vitro and in Prostate Cancer Cells

Abstract Insulin-like growth factor (IGF)-II plays an important role in fetal growth and development. IGFs are potent mitogens for a variety of cancer cells. A paracrine/autocrine role of IGF-II in the growth of breast and prostate cancer cells has been suggested. To test the role of IGF-II in cance...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-05, Vol.140 (5), p.2134-2144
Hauptverfasser:	Xu, Zhao-Dong, Oey, Lily, Mohan, Subburaman, Kawachi, Mark H., Lee, Nan-Sook, Rossi, John J., Fujita-Yamaguchi, Yoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Autocrine signalling Base Sequence Catalysis Cell Division Cell growth Fetuses Gene Expression Growth factors Humans Insulin Insulin-like growth factor II Insulin-Like Growth Factor II - genetics Insulin-like growth factors Kinetics Male Mitogens Molecular Sequence Data mRNA Nucleic Acid Conformation Paracrine signalling Promoter Regions, Genetic Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Ribonucleic acid Ribozymes RNA RNA - metabolism RNA Polymerase III - genetics RNA, Catalytic - chemistry RNA, Catalytic - metabolism RNA, Messenger - metabolism Structure-Activity Relationship Tumor Cells, Cultured
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