Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial
Abstract Background Surgeons commonly see postoperative hypoalbuminemia, but whether exogenous albumin administration is beneficial for these patients is unclear. Methods A prospective, randomized study design was used, allocating 127 hypoalbuminemic patients into the albumin or saline group after g...
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| Veröffentlicht in: | The American journal of surgery 2008-11, Vol.196 (5), p.751-755 |
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| creator | Yuan, Xi-Yu, M.M Zhang, Chang-Hua, M.D He, Yu-Long, M.D Yuan, Yan-Xian, B.M Cai, Shi-Rong, M.D Luo, Ning-Xiang, B.M Zhan, Wen-Hua, M.D Cui, Ji, M.D |
| description | Abstract Background Surgeons commonly see postoperative hypoalbuminemia, but whether exogenous albumin administration is beneficial for these patients is unclear. Methods A prospective, randomized study design was used, allocating 127 hypoalbuminemic patients into the albumin or saline group after gastrointestinal surgery. We investigated the development of postoperative hypoalbuminemia, nutritional status, postoperative fluid balance, postoperative complications, and postoperative hospital stay. Results Plasma albumin concentrations of both groups decreased after operations ( P .05) in changes in postoperative plasma albumin concentration from baseline levels. Postoperative plasma albumin, total protein, and prealbumin levels were similar in the 2 groups. While 3-day and 5-day recovery ratios were similar, 7-day recovery ratios were lower in the albumin group ( P |
| doi_str_mv | 10.1016/j.amjsurg.2007.10.030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69716428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0002961008003553</els_id><sourcerecordid>69716428</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-bdc13356c5a1dc9792c433e82e1199174693490f180ed00cc5736e4f2133747e3</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhJ4AsIbjt4q8kNgcqVPFRqRIH4Gx5ncnixYmDnRSFv8MfZcJGVOqFSxzbz7yemXeK4imjO0ZZ9eq4s90xT-mw45TWeLajgt4rNkzVesuUEveLDaWUb3XF6FnxKOcjbhmT4mFxxlQltar0pvh9lYkN-6nzPbENfn0ekx197Mkeemi98zYQvASbwkzyaA9AYkuGmMc4wILeAPk2D3FVgc5b0sYQ4k_fH8jBol70_Qh59D1KLSlDmi9eE0uGFPMA7q9Esn0TO_8LGuJijzEh4O-Y8PnHxYPWhgxP1vW8-Pr-3ZfLj9vrTx-uLt9eb10p-bjdN44JUVautKxxutbcSSFAcWBMa1bLSgupacsUhYZS58paVCBbjlG1rEGcFy9PupjXjwkTNp3PDkKwPcQpm0rXrJJcIfj8DniMU8LqsmFSylJJXQmkyhPlsMycoDVD8p1Ns2HULB6ao1k9NIuHyzF6iHHPVvVp30FzG7WahsCLFbDZ2dBi65zP_zhOFZey4shdnDjApt14SCY7D72Dxifsummi_28qb-4ouIAjgo9-hxnybdUmc0PN52XglnmjilJRlkL8Af5v1aY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1444584963</pqid></control><display><type>article</type><title>Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Yuan, Xi-Yu, M.M ; Zhang, Chang-Hua, M.D ; He, Yu-Long, M.D ; Yuan, Yan-Xian, B.M ; Cai, Shi-Rong, M.D ; Luo, Ning-Xiang, B.M ; Zhan, Wen-Hua, M.D ; Cui, Ji, M.D</creator><creatorcontrib>Yuan, Xi-Yu, M.M ; Zhang, Chang-Hua, M.D ; He, Yu-Long, M.D ; Yuan, Yan-Xian, B.M ; Cai, Shi-Rong, M.D ; Luo, Ning-Xiang, B.M ; Zhan, Wen-Hua, M.D ; Cui, Ji, M.D</creatorcontrib><description>Abstract Background Surgeons commonly see postoperative hypoalbuminemia, but whether exogenous albumin administration is beneficial for these patients is unclear. Methods A prospective, randomized study design was used, allocating 127 hypoalbuminemic patients into the albumin or saline group after gastrointestinal surgery. We investigated the development of postoperative hypoalbuminemia, nutritional status, postoperative fluid balance, postoperative complications, and postoperative hospital stay. Results Plasma albumin concentrations of both groups decreased after operations ( P <.01). No significant differences were found between groups ( P >.05) in changes in postoperative plasma albumin concentration from baseline levels. Postoperative plasma albumin, total protein, and prealbumin levels were similar in the 2 groups. While 3-day and 5-day recovery ratios were similar, 7-day recovery ratios were lower in the albumin group ( P <.05). No significant difference was found in overall fluid administration, urine output, or the incidence of postoperative complications between groups (23.4% for albumin group and 12.7% for control group, P = .116). Conclusions Albumin administration in the early stage of postoperative hypoalbuminemia following gastrointestinal surgery is not beneficial in correcting hypoalbuminemia or in clinical outcomes.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2007.10.030</identifier><identifier>PMID: 18649869</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Albumin administration ; Albumins - administration & dosage ; Biological and medical sciences ; Chi-Square Distribution ; Confidence intervals ; Digestive System Surgical Procedures ; Female ; Gastric cancer ; Gastrointestinal surgery ; General aspects ; Growth hormones ; Humans ; Hypoalbuminemia - drug therapy ; Male ; Medical sciences ; Middle Aged ; Patients ; Plasma ; Postoperative Complications - drug therapy ; Postoperative hypoalbuminemia ; Prospective Studies ; Proteins ; Statistical methods ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Treatment Outcome</subject><ispartof>The American journal of surgery, 2008-11, Vol.196 (5), p.751-755</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-bdc13356c5a1dc9792c433e82e1199174693490f180ed00cc5736e4f2133747e3</citedby><cites>FETCH-LOGICAL-c542t-bdc13356c5a1dc9792c433e82e1199174693490f180ed00cc5736e4f2133747e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1444584963?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20824462$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18649869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Xi-Yu, M.M</creatorcontrib><creatorcontrib>Zhang, Chang-Hua, M.D</creatorcontrib><creatorcontrib>He, Yu-Long, M.D</creatorcontrib><creatorcontrib>Yuan, Yan-Xian, B.M</creatorcontrib><creatorcontrib>Cai, Shi-Rong, M.D</creatorcontrib><creatorcontrib>Luo, Ning-Xiang, B.M</creatorcontrib><creatorcontrib>Zhan, Wen-Hua, M.D</creatorcontrib><creatorcontrib>Cui, Ji, M.D</creatorcontrib><title>Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Surgeons commonly see postoperative hypoalbuminemia, but whether exogenous albumin administration is beneficial for these patients is unclear. Methods A prospective, randomized study design was used, allocating 127 hypoalbuminemic patients into the albumin or saline group after gastrointestinal surgery. We investigated the development of postoperative hypoalbuminemia, nutritional status, postoperative fluid balance, postoperative complications, and postoperative hospital stay. Results Plasma albumin concentrations of both groups decreased after operations ( P <.01). No significant differences were found between groups ( P >.05) in changes in postoperative plasma albumin concentration from baseline levels. Postoperative plasma albumin, total protein, and prealbumin levels were similar in the 2 groups. While 3-day and 5-day recovery ratios were similar, 7-day recovery ratios were lower in the albumin group ( P <.05). No significant difference was found in overall fluid administration, urine output, or the incidence of postoperative complications between groups (23.4% for albumin group and 12.7% for control group, P = .116). Conclusions Albumin administration in the early stage of postoperative hypoalbuminemia following gastrointestinal surgery is not beneficial in correcting hypoalbuminemia or in clinical outcomes.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albumin administration</subject><subject>Albumins - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Confidence intervals</subject><subject>Digestive System Surgical Procedures</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastrointestinal surgery</subject><subject>General aspects</subject><subject>Growth hormones</subject><subject>Humans</subject><subject>Hypoalbuminemia - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Plasma</subject><subject>Postoperative Complications - drug therapy</subject><subject>Postoperative hypoalbuminemia</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Statistical methods</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Treatment Outcome</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk1v1DAQhiMEokvhJ4AsIbjt4q8kNgcqVPFRqRIH4Gx5ncnixYmDnRSFv8MfZcJGVOqFSxzbz7yemXeK4imjO0ZZ9eq4s90xT-mw45TWeLajgt4rNkzVesuUEveLDaWUb3XF6FnxKOcjbhmT4mFxxlQltar0pvh9lYkN-6nzPbENfn0ekx197Mkeemi98zYQvASbwkzyaA9AYkuGmMc4wILeAPk2D3FVgc5b0sYQ4k_fH8jBol70_Qh59D1KLSlDmi9eE0uGFPMA7q9Esn0TO_8LGuJijzEh4O-Y8PnHxYPWhgxP1vW8-Pr-3ZfLj9vrTx-uLt9eb10p-bjdN44JUVautKxxutbcSSFAcWBMa1bLSgupacsUhYZS58paVCBbjlG1rEGcFy9PupjXjwkTNp3PDkKwPcQpm0rXrJJcIfj8DniMU8LqsmFSylJJXQmkyhPlsMycoDVD8p1Ns2HULB6ao1k9NIuHyzF6iHHPVvVp30FzG7WahsCLFbDZ2dBi65zP_zhOFZey4shdnDjApt14SCY7D72Dxifsummi_28qb-4ouIAjgo9-hxnybdUmc0PN52XglnmjilJRlkL8Af5v1aY</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Yuan, Xi-Yu, M.M</creator><creator>Zhang, Chang-Hua, M.D</creator><creator>He, Yu-Long, M.D</creator><creator>Yuan, Yan-Xian, B.M</creator><creator>Cai, Shi-Rong, M.D</creator><creator>Luo, Ning-Xiang, B.M</creator><creator>Zhan, Wen-Hua, M.D</creator><creator>Cui, Ji, M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial</title><author>Yuan, Xi-Yu, M.M ; Zhang, Chang-Hua, M.D ; He, Yu-Long, M.D ; Yuan, Yan-Xian, B.M ; Cai, Shi-Rong, M.D ; Luo, Ning-Xiang, B.M ; Zhan, Wen-Hua, M.D ; Cui, Ji, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-bdc13356c5a1dc9792c433e82e1199174693490f180ed00cc5736e4f2133747e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albumin administration</topic><topic>Albumins - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Confidence intervals</topic><topic>Digestive System Surgical Procedures</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastrointestinal surgery</topic><topic>General aspects</topic><topic>Growth hormones</topic><topic>Humans</topic><topic>Hypoalbuminemia - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Plasma</topic><topic>Postoperative Complications - drug therapy</topic><topic>Postoperative hypoalbuminemia</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Statistical methods</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Xi-Yu, M.M</creatorcontrib><creatorcontrib>Zhang, Chang-Hua, M.D</creatorcontrib><creatorcontrib>He, Yu-Long, M.D</creatorcontrib><creatorcontrib>Yuan, Yan-Xian, B.M</creatorcontrib><creatorcontrib>Cai, Shi-Rong, M.D</creatorcontrib><creatorcontrib>Luo, Ning-Xiang, B.M</creatorcontrib><creatorcontrib>Zhan, Wen-Hua, M.D</creatorcontrib><creatorcontrib>Cui, Ji, M.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Xi-Yu, M.M</au><au>Zhang, Chang-Hua, M.D</au><au>He, Yu-Long, M.D</au><au>Yuan, Yan-Xian, B.M</au><au>Cai, Shi-Rong, M.D</au><au>Luo, Ning-Xiang, B.M</au><au>Zhan, Wen-Hua, M.D</au><au>Cui, Ji, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>196</volume><issue>5</issue><spage>751</spage><epage>755</epage><pages>751-755</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Abstract Background Surgeons commonly see postoperative hypoalbuminemia, but whether exogenous albumin administration is beneficial for these patients is unclear. Methods A prospective, randomized study design was used, allocating 127 hypoalbuminemic patients into the albumin or saline group after gastrointestinal surgery. We investigated the development of postoperative hypoalbuminemia, nutritional status, postoperative fluid balance, postoperative complications, and postoperative hospital stay. Results Plasma albumin concentrations of both groups decreased after operations ( P <.01). No significant differences were found between groups ( P >.05) in changes in postoperative plasma albumin concentration from baseline levels. Postoperative plasma albumin, total protein, and prealbumin levels were similar in the 2 groups. While 3-day and 5-day recovery ratios were similar, 7-day recovery ratios were lower in the albumin group ( P <.05). No significant difference was found in overall fluid administration, urine output, or the incidence of postoperative complications between groups (23.4% for albumin group and 12.7% for control group, P = .116). Conclusions Albumin administration in the early stage of postoperative hypoalbuminemia following gastrointestinal surgery is not beneficial in correcting hypoalbuminemia or in clinical outcomes.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18649869</pmid><doi>10.1016/j.amjsurg.2007.10.030</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Albumin administration Albumins - administration & dosage Biological and medical sciences Chi-Square Distribution Confidence intervals Digestive System Surgical Procedures Female Gastric cancer Gastrointestinal surgery General aspects Growth hormones Humans Hypoalbuminemia - drug therapy Male Medical sciences Middle Aged Patients Plasma Postoperative Complications - drug therapy Postoperative hypoalbuminemia Prospective Studies Proteins Statistical methods Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Treatment Outcome |
| title | Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial |
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