Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease: 2-year follow-up of the MASS II study
OBJECTIVEWe characterized the impact of the metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years. METHODSPatients enrolled in the MASS II study were e...
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| Veröffentlicht in: | Coronary artery disease 2008-09, Vol.19 (6), p.383-388 |
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| creator | Lopes, Neuza H Paulitsch, Felipe S Pereira, Alexandre C Góis, Aécio F Gagliardi, Antônio Garzillo, Cibele L Ferreira, João F Stolf, Noedir A Hueb, Whady |
| description | OBJECTIVEWe characterized the impact of the metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years.
METHODSPatients enrolled in the MASS II study were evaluated for each component of the MetS, as well as the full syndrome.
RESULTSThe criteria for MetS were fulfilled in 52% of patients. The presence of MetS (P |
| doi_str_mv | 10.1097/MCA.0b013e328306aa8a |
| format | Article |
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METHODSPatients enrolled in the MASS II study were evaluated for each component of the MetS, as well as the full syndrome.
RESULTSThe criteria for MetS were fulfilled in 52% of patients. The presence of MetS (P<0.05), glucose intolerance (P=0.007), and diabetes (P=0.04) was associated with an increased mortality in our studied population. Moreover, despite a clear tendency for each of its components to increase the mortality risk, only the presence of the MetS significantly increased the risk of mortality among nondiabetic study participants in a multivariate model (P=0.03, relative risk 3.5, 95% confidence interval 1.1–6). Finally, MetS was still associated with increased mortality even after adjustment for diabetes status. These results indicate a strong and consistent relationship of the MetS with mortality in patients with stable coronary artery disease.
CONCLUSIONAlthough glucose homeostasis seems to be the major force driving the increased risk of MetS, the operational diagnosis of MetS still has information for stratifying patients when diabetes information is taken into account.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/MCA.0b013e328306aa8a</identifier><identifier>PMID: 18955830</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Blood Glucose - metabolism ; Brazil - epidemiology ; Confidence Intervals ; Coronary Angiography ; Coronary Disease - complications ; Coronary Disease - diagnostic imaging ; Coronary Disease - mortality ; Female ; Follow-Up Studies ; Humans ; Male ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Metabolic Syndrome - mortality ; Middle Aged ; Odds Ratio ; Prognosis ; Prospective Studies ; Risk Factors ; Severity of Illness Index ; Survival Rate - trends ; Time Factors</subject><ispartof>Coronary artery disease, 2008-09, Vol.19 (6), p.383-388</ispartof><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3502-b553200b6d4271ad29f0e70ecd5fd398db2896a9d98f20851661324ed0a8a11f3</citedby><cites>FETCH-LOGICAL-c3502-b553200b6d4271ad29f0e70ecd5fd398db2896a9d98f20851661324ed0a8a11f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18955830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopes, Neuza H</creatorcontrib><creatorcontrib>Paulitsch, Felipe S</creatorcontrib><creatorcontrib>Pereira, Alexandre C</creatorcontrib><creatorcontrib>Góis, Aécio F</creatorcontrib><creatorcontrib>Gagliardi, Antônio</creatorcontrib><creatorcontrib>Garzillo, Cibele L</creatorcontrib><creatorcontrib>Ferreira, João F</creatorcontrib><creatorcontrib>Stolf, Noedir A</creatorcontrib><creatorcontrib>Hueb, Whady</creatorcontrib><title>Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease: 2-year follow-up of the MASS II study</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>OBJECTIVEWe characterized the impact of the metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years.
METHODSPatients enrolled in the MASS II study were evaluated for each component of the MetS, as well as the full syndrome.
RESULTSThe criteria for MetS were fulfilled in 52% of patients. The presence of MetS (P<0.05), glucose intolerance (P=0.007), and diabetes (P=0.04) was associated with an increased mortality in our studied population. Moreover, despite a clear tendency for each of its components to increase the mortality risk, only the presence of the MetS significantly increased the risk of mortality among nondiabetic study participants in a multivariate model (P=0.03, relative risk 3.5, 95% confidence interval 1.1–6). Finally, MetS was still associated with increased mortality even after adjustment for diabetes status. These results indicate a strong and consistent relationship of the MetS with mortality in patients with stable coronary artery disease.
CONCLUSIONAlthough glucose homeostasis seems to be the major force driving the increased risk of MetS, the operational diagnosis of MetS still has information for stratifying patients when diabetes information is taken into account.</description><subject>Blood Glucose - metabolism</subject><subject>Brazil - epidemiology</subject><subject>Confidence Intervals</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - mortality</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - mortality</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9r3DAQxUVpaTZpv0EpOvXmdCRZttTbsvTPQkIPac9GtkasW9lyJZllr_3k1TYLgRzEY4b3HsxPhLxjcMtAtx_vd9tb6IEJFFwJaIxR5gXZsLoVlSyLl2QDWtZVo7m6Itcp_QJgtWzla3LFlJZnz4b83U-LGTINjk6YTR_8ONB0mm0ME9Iw03wosubh_-joYvKIc070OOYDTSXhkQ4hhtnEEzUxYxE7JjQJP1FendBE6oL34Vity7nhXHi_fXig-33Jr_b0hrxyxid8e9Eb8vPL5x-7b9Xd96_73fauGoQEXvVSCg7QN7bmLTOWawfYAg5WOiu0sj1XujHaauU4KMmahgleo4UChjEnbsiHx94lhj8rptxNYxrQezNjWFPX6JZJLXQx1o_GIYaUIrpuieNU7usYdGf2XWHfPWdfYu8v_Ws_oX0KXWA_9R6DL5zSb78eMXYHND4fOijfoyWwqhypQJexKg-4-AcMo5EI</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Lopes, Neuza H</creator><creator>Paulitsch, Felipe S</creator><creator>Pereira, Alexandre C</creator><creator>Góis, Aécio F</creator><creator>Gagliardi, Antônio</creator><creator>Garzillo, Cibele L</creator><creator>Ferreira, João F</creator><creator>Stolf, Noedir A</creator><creator>Hueb, Whady</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200809</creationdate><title>Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease: 2-year follow-up of the MASS II study</title><author>Lopes, Neuza H ; Paulitsch, Felipe S ; Pereira, Alexandre C ; Góis, Aécio F ; Gagliardi, Antônio ; Garzillo, Cibele L ; Ferreira, João F ; Stolf, Noedir A ; Hueb, Whady</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3502-b553200b6d4271ad29f0e70ecd5fd398db2896a9d98f20851661324ed0a8a11f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Blood Glucose - metabolism</topic><topic>Brazil - epidemiology</topic><topic>Confidence Intervals</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - complications</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - mortality</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - mortality</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopes, Neuza H</creatorcontrib><creatorcontrib>Paulitsch, Felipe S</creatorcontrib><creatorcontrib>Pereira, Alexandre C</creatorcontrib><creatorcontrib>Góis, Aécio F</creatorcontrib><creatorcontrib>Gagliardi, Antônio</creatorcontrib><creatorcontrib>Garzillo, Cibele L</creatorcontrib><creatorcontrib>Ferreira, João F</creatorcontrib><creatorcontrib>Stolf, Noedir A</creatorcontrib><creatorcontrib>Hueb, Whady</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopes, Neuza H</au><au>Paulitsch, Felipe S</au><au>Pereira, Alexandre C</au><au>Góis, Aécio F</au><au>Gagliardi, Antônio</au><au>Garzillo, Cibele L</au><au>Ferreira, João F</au><au>Stolf, Noedir A</au><au>Hueb, Whady</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease: 2-year follow-up of the MASS II study</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2008-09</date><risdate>2008</risdate><volume>19</volume><issue>6</issue><spage>383</spage><epage>388</epage><pages>383-388</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>OBJECTIVEWe characterized the impact of the metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years.
METHODSPatients enrolled in the MASS II study were evaluated for each component of the MetS, as well as the full syndrome.
RESULTSThe criteria for MetS were fulfilled in 52% of patients. The presence of MetS (P<0.05), glucose intolerance (P=0.007), and diabetes (P=0.04) was associated with an increased mortality in our studied population. Moreover, despite a clear tendency for each of its components to increase the mortality risk, only the presence of the MetS significantly increased the risk of mortality among nondiabetic study participants in a multivariate model (P=0.03, relative risk 3.5, 95% confidence interval 1.1–6). Finally, MetS was still associated with increased mortality even after adjustment for diabetes status. These results indicate a strong and consistent relationship of the MetS with mortality in patients with stable coronary artery disease.
CONCLUSIONAlthough glucose homeostasis seems to be the major force driving the increased risk of MetS, the operational diagnosis of MetS still has information for stratifying patients when diabetes information is taken into account.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18955830</pmid><doi>10.1097/MCA.0b013e328306aa8a</doi><tpages>6</tpages></addata></record> |
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| subjects | Blood Glucose - metabolism Brazil - epidemiology Confidence Intervals Coronary Angiography Coronary Disease - complications Coronary Disease - diagnostic imaging Coronary Disease - mortality Female Follow-Up Studies Humans Male Metabolic Syndrome - blood Metabolic Syndrome - complications Metabolic Syndrome - mortality Middle Aged Odds Ratio Prognosis Prospective Studies Risk Factors Severity of Illness Index Survival Rate - trends Time Factors |
| title | Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease: 2-year follow-up of the MASS II study |
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