Sequences downstream of the RNA initiation site of the HTLV type I long terminal repeat are sufficient for trans-activation by human cytomegalovirus immediate-early proteins
Human T cell leukemia virus type I infection is associated with a low incidence of morbidity in the form of adult T cell leukemia and neurologic disease, suggesting that there are other factors determining the pathogenic outcome of infection. We found that HCMV could infect various human cell lines...
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| Veröffentlicht in: | AIDS research and human retroviruses 1999-04, Vol.15 (6), p.545-550 |
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| container_title | AIDS research and human retroviruses |
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| creator | KIM, J.-M HONG, Y KIM, Sujeong CHO, M.-H YOSHIDA, M JEANG, K.-T BURNS, W KIM, Sunyoung |
| description | Human T cell leukemia virus type I infection is associated with a low incidence of morbidity in the form of adult T cell leukemia and neurologic disease, suggesting that there are other factors determining the pathogenic outcome of infection. We found that HCMV could infect various human cell lines known to be susceptible to HTLV-I infection, including T cell lines already harboring HTLV-I, and that HCMV infection could highly activate gene expression from the HTLV-I LTR. In addition, the coexpression of IE1 and IE2 genes of HCMV increased transcription from the HTLV-I LTR. The deletion analysis indicated that the entire U3 region is not required, but that the 216-bp region from +101 to +316 is sufficient for activation of the LTR by IE1 and IE2. These results suggest that HCMV IE proteins may affect the level of HTLV-I gene expression in coinfected individuals by interacting with HTLV-I LTR sequences. |
| doi_str_mv | 10.1089/088922299311060 |
| format | Article |
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We found that HCMV could infect various human cell lines known to be susceptible to HTLV-I infection, including T cell lines already harboring HTLV-I, and that HCMV infection could highly activate gene expression from the HTLV-I LTR. In addition, the coexpression of IE1 and IE2 genes of HCMV increased transcription from the HTLV-I LTR. The deletion analysis indicated that the entire U3 region is not required, but that the 216-bp region from +101 to +316 is sufficient for activation of the LTR by IE1 and IE2. These results suggest that HCMV IE proteins may affect the level of HTLV-I gene expression in coinfected individuals by interacting with HTLV-I LTR sequences.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/088922299311060</identifier><identifier>PMID: 10221531</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Antigens, Viral - genetics ; Binding Sites ; Biological and medical sciences ; Cytomegalovirus - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Viral ; Genetics ; Human T-lymphotropic virus 1 - genetics ; Humans ; Immediate-Early Proteins - genetics ; Microbiology ; RNA, Viral ; Terminal Repeat Sequences ; Transcriptional Activation ; Tumor Cells, Cultured ; U937 Cells ; Viral Proteins ; Virology</subject><ispartof>AIDS research and human retroviruses, 1999-04, Vol.15 (6), p.545-550</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-60e5d575d28eb27d2622f6180055c6091bd5ec1d1cb234ae3400ae56decf0ac63</citedby><cites>FETCH-LOGICAL-c322t-60e5d575d28eb27d2622f6180055c6091bd5ec1d1cb234ae3400ae56decf0ac63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3040,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1833192$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10221531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIM, J.-M</creatorcontrib><creatorcontrib>HONG, Y</creatorcontrib><creatorcontrib>KIM, Sujeong</creatorcontrib><creatorcontrib>CHO, M.-H</creatorcontrib><creatorcontrib>YOSHIDA, M</creatorcontrib><creatorcontrib>JEANG, K.-T</creatorcontrib><creatorcontrib>BURNS, W</creatorcontrib><creatorcontrib>KIM, Sunyoung</creatorcontrib><title>Sequences downstream of the RNA initiation site of the HTLV type I long terminal repeat are sufficient for trans-activation by human cytomegalovirus immediate-early proteins</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>Human T cell leukemia virus type I infection is associated with a low incidence of morbidity in the form of adult T cell leukemia and neurologic disease, suggesting that there are other factors determining the pathogenic outcome of infection. We found that HCMV could infect various human cell lines known to be susceptible to HTLV-I infection, including T cell lines already harboring HTLV-I, and that HCMV infection could highly activate gene expression from the HTLV-I LTR. In addition, the coexpression of IE1 and IE2 genes of HCMV increased transcription from the HTLV-I LTR. The deletion analysis indicated that the entire U3 region is not required, but that the 216-bp region from +101 to +316 is sufficient for activation of the LTR by IE1 and IE2. These results suggest that HCMV IE proteins may affect the level of HTLV-I gene expression in coinfected individuals by interacting with HTLV-I LTR sequences.</description><subject>AIDS/HIV</subject><subject>Antigens, Viral - genetics</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Cytomegalovirus - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Viral</subject><subject>Genetics</subject><subject>Human T-lymphotropic virus 1 - genetics</subject><subject>Humans</subject><subject>Immediate-Early Proteins - genetics</subject><subject>Microbiology</subject><subject>RNA, Viral</subject><subject>Terminal Repeat Sequences</subject><subject>Transcriptional Activation</subject><subject>Tumor Cells, Cultured</subject><subject>U937 Cells</subject><subject>Viral Proteins</subject><subject>Virology</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFv1DAQhS0EokvhzA3NAfUWOrbX2eRYVdBWWoHUFq6R44xbo8RebKcoP4r_iFe7CMRpRnrfvNHMY-wtxw8cm_Ycm6YVQrSt5BxrfMZWvLRVs0b1nK32arWXT9irlL4jYoHVS3bCUQiuJF-xX3f0YyZvKMEQfvqUI-kJgoX8SHD7-QKcd9np7IKH5DL9ka7vt98gLzuCGxiDf4BMcXJejxBpRzqDjgRpttYZRz6DDRFy1D5V2mT3dDDsF3icJ-3BLDlM9KDH8OTinMBNEw1lK1Wk47jALoZMzqfX7IXVY6I3x3rKvn76eH95XW2_XN1cXmwrI4XIVY2kBrVRg2ioF5tB1ELYmjeISpkaW94PigwfuOmFXGuSa0RNqh7IWNSmlqfs7OBbFpf3pNxNLhkaR-0pzKmr2w1Xat0U8PwAmhhSimS7XXSTjkvHsdsn1P2XUJl4d7Se-3LkP_whkgK8PwI6GT3a8jTj0l-ukZK3Qv4GboWbrQ</recordid><startdate>19990410</startdate><enddate>19990410</enddate><creator>KIM, J.-M</creator><creator>HONG, Y</creator><creator>KIM, Sujeong</creator><creator>CHO, M.-H</creator><creator>YOSHIDA, M</creator><creator>JEANG, K.-T</creator><creator>BURNS, W</creator><creator>KIM, Sunyoung</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990410</creationdate><title>Sequences downstream of the RNA initiation site of the HTLV type I long terminal repeat are sufficient for trans-activation by human cytomegalovirus immediate-early proteins</title><author>KIM, J.-M ; HONG, Y ; KIM, Sujeong ; CHO, M.-H ; YOSHIDA, M ; JEANG, K.-T ; BURNS, W ; KIM, Sunyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-60e5d575d28eb27d2622f6180055c6091bd5ec1d1cb234ae3400ae56decf0ac63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>AIDS/HIV</topic><topic>Antigens, Viral - genetics</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Cytomegalovirus - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Viral</topic><topic>Genetics</topic><topic>Human T-lymphotropic virus 1 - genetics</topic><topic>Humans</topic><topic>Immediate-Early Proteins - genetics</topic><topic>Microbiology</topic><topic>RNA, Viral</topic><topic>Terminal Repeat Sequences</topic><topic>Transcriptional Activation</topic><topic>Tumor Cells, Cultured</topic><topic>U937 Cells</topic><topic>Viral Proteins</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIM, J.-M</creatorcontrib><creatorcontrib>HONG, Y</creatorcontrib><creatorcontrib>KIM, Sujeong</creatorcontrib><creatorcontrib>CHO, M.-H</creatorcontrib><creatorcontrib>YOSHIDA, M</creatorcontrib><creatorcontrib>JEANG, K.-T</creatorcontrib><creatorcontrib>BURNS, W</creatorcontrib><creatorcontrib>KIM, Sunyoung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIM, J.-M</au><au>HONG, Y</au><au>KIM, Sujeong</au><au>CHO, M.-H</au><au>YOSHIDA, M</au><au>JEANG, K.-T</au><au>BURNS, W</au><au>KIM, Sunyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequences downstream of the RNA initiation site of the HTLV type I long terminal repeat are sufficient for trans-activation by human cytomegalovirus immediate-early proteins</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>1999-04-10</date><risdate>1999</risdate><volume>15</volume><issue>6</issue><spage>545</spage><epage>550</epage><pages>545-550</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>Human T cell leukemia virus type I infection is associated with a low incidence of morbidity in the form of adult T cell leukemia and neurologic disease, suggesting that there are other factors determining the pathogenic outcome of infection. We found that HCMV could infect various human cell lines known to be susceptible to HTLV-I infection, including T cell lines already harboring HTLV-I, and that HCMV infection could highly activate gene expression from the HTLV-I LTR. In addition, the coexpression of IE1 and IE2 genes of HCMV increased transcription from the HTLV-I LTR. The deletion analysis indicated that the entire U3 region is not required, but that the 216-bp region from +101 to +316 is sufficient for activation of the LTR by IE1 and IE2. These results suggest that HCMV IE proteins may affect the level of HTLV-I gene expression in coinfected individuals by interacting with HTLV-I LTR sequences.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>10221531</pmid><doi>10.1089/088922299311060</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0889-2229 |
| ispartof | AIDS research and human retroviruses, 1999-04, Vol.15 (6), p.545-550 |
| issn | 0889-2229 1931-8405 |
| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Antigens, Viral - genetics Binding Sites Biological and medical sciences Cytomegalovirus - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Viral Genetics Human T-lymphotropic virus 1 - genetics Humans Immediate-Early Proteins - genetics Microbiology RNA, Viral Terminal Repeat Sequences Transcriptional Activation Tumor Cells, Cultured U937 Cells Viral Proteins Virology |
| title | Sequences downstream of the RNA initiation site of the HTLV type I long terminal repeat are sufficient for trans-activation by human cytomegalovirus immediate-early proteins |
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