Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer
BACKGROUND p21(waf1/cip1) protein is a cyclin‐dependent kinase inhibitor able to arrest the cell cycle at the G1 phase by inhibiting DNA replication. The expression of p21(waf1/cip1) and its prognostic value in prostate cancer are largely unexplored. METHODS We used immunohistochemistry to analyze t...
Gespeichert in:
| Veröffentlicht in: | The Prostate 1999-04, Vol.39 (1), p.8-15 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 15 |
|---|---|
| container_issue | 1 |
| container_start_page | 8 |
| container_title | The Prostate |
| container_volume | 39 |
| creator | Aaltomaa, S. Lipponen, P. Eskelinen, M. Ala-Opas, M. Kosma, V.M. |
| description | BACKGROUND
p21(waf1/cip1) protein is a cyclin‐dependent kinase inhibitor able to arrest the cell cycle at the G1 phase by inhibiting DNA replication. The expression of p21(waf1/cip1) and its prognostic value in prostate cancer are largely unexplored.
METHODS
We used immunohistochemistry to analyze the expression of p21(waf1/cip1) in 213 prostate cancer cases, and the results were related to other known prognostic factors and patient survival during a long‐term follow‐up.
RESULTS
The expression of p21 (waf1/cip1) protein was significantly associated with high Gleason score (P = 0.001), DNA aneuploidy (P = 0.013), high S‐phase fraction (P = 0.019), and expression of Ki‐67 (P = 0.021) and bcl‐2 (P = 0.001) as well as cyclin A (P = 0.035) and D proteins (P < 0.001). In univariate survival analysis the signal of p21(waf1/cip1) was significantly related to unfavorable prognosis (P = 0.010) both in the entire cohort and in local tumors (P = 0.034). In multivariate analysis, M‐category, clinical T‐category, Gleason score, and patient age were independent prognostic factors. In local tumors the expression of p21(waf1/cip1) together with clinical T‐category and S‐phase fraction were significant independent predictors of cancer related survival.
CONCLUSIONS
The results suggest that the expression of p21(waf1/cip1) protein is associated both with cell proliferation and patient survival in prostate cancer. Prostate 39:8–15, 1999. © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0045(19990401)39:1<8::AID-PROS2>3.0.CO;2-N |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69714964</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69714964</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4312-326b40a65228909ca6d47e29549853de22233550f5558330bbe955d2af320abe3</originalsourceid><addsrcrecordid>eNqFkNGK00AUhgdR3Lr6CpILkfYi3TNnMkmn6sKS6loo6eKuCt4cJslEsqZJNpO6u2_v1NQqKAgDZxj-883Px9gbDlMOgCfjy2W8nHBQkQ8QyDFXSkEAfCLUnL-ezedny4V_8WF9iadiCtN4_Qr95AEbHTYeshFgBH7ARXTEnlh7DeDIgI_ZEQdEjiGM2Oqia77Wje3LzPuuq63xdJ175q7tjLVlU3tN4bXIx7e64CdZ2fKJ13ZNb8rac8ddba9742W6zkz3lD0qdGXNs_08Zh_fvb2K3_ur9fkyPlv5WSA4-gLDNAAdSsSZApXpMA8ig0oGaiZFbhBRCCmhkFLOhIA0NUrKHHUhEHRqxDF7OXDd_zdbY3valDYzVaVr02wthSrigQoDcSiQuaK2MwW1XbnR3T1xoJ1mop1m2kmjnTT6pZmEIk4zIqeZfmomQUDxmpASx32-L7BNNyb_gzp4dYEX-4C2ma6Kzvkp7e9chGGEkYt9GmK3ZWXu_yr3n27_qjY8OLA_gEvbm7sDWHffKIxEJOlzck5hskiuvvCAFuIHTDCxxA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69714964</pqid></control><display><type>article</type><title>Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Aaltomaa, S. ; Lipponen, P. ; Eskelinen, M. ; Ala-Opas, M. ; Kosma, V.M.</creator><creatorcontrib>Aaltomaa, S. ; Lipponen, P. ; Eskelinen, M. ; Ala-Opas, M. ; Kosma, V.M.</creatorcontrib><description>BACKGROUND
p21(waf1/cip1) protein is a cyclin‐dependent kinase inhibitor able to arrest the cell cycle at the G1 phase by inhibiting DNA replication. The expression of p21(waf1/cip1) and its prognostic value in prostate cancer are largely unexplored.
METHODS
We used immunohistochemistry to analyze the expression of p21(waf1/cip1) in 213 prostate cancer cases, and the results were related to other known prognostic factors and patient survival during a long‐term follow‐up.
RESULTS
The expression of p21 (waf1/cip1) protein was significantly associated with high Gleason score (P = 0.001), DNA aneuploidy (P = 0.013), high S‐phase fraction (P = 0.019), and expression of Ki‐67 (P = 0.021) and bcl‐2 (P = 0.001) as well as cyclin A (P = 0.035) and D proteins (P < 0.001). In univariate survival analysis the signal of p21(waf1/cip1) was significantly related to unfavorable prognosis (P = 0.010) both in the entire cohort and in local tumors (P = 0.034). In multivariate analysis, M‐category, clinical T‐category, Gleason score, and patient age were independent prognostic factors. In local tumors the expression of p21(waf1/cip1) together with clinical T‐category and S‐phase fraction were significant independent predictors of cancer related survival.
CONCLUSIONS
The results suggest that the expression of p21(waf1/cip1) protein is associated both with cell proliferation and patient survival in prostate cancer. Prostate 39:8–15, 1999. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/(SICI)1097-0045(19990401)39:1<8::AID-PROS2>3.0.CO;2-N</identifier><identifier>PMID: 10221260</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Aged ; Biological and medical sciences ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins - biosynthesis ; Enzyme Inhibitors - metabolism ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; p21(waf1/cip1) ; Prognosis ; prostate neoplasm ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Survival Rate ; Time Factors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>The Prostate, 1999-04, Vol.39 (1), p.8-15</ispartof><rights>Copyright © 1999 Wiley‐Liss, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4312-326b40a65228909ca6d47e29549853de22233550f5558330bbe955d2af320abe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0045%2819990401%2939%3A1%3C8%3A%3AAID-PROS2%3E3.0.CO%3B2-N$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0045%2819990401%2939%3A1%3C8%3A%3AAID-PROS2%3E3.0.CO%3B2-N$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1726727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10221260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aaltomaa, S.</creatorcontrib><creatorcontrib>Lipponen, P.</creatorcontrib><creatorcontrib>Eskelinen, M.</creatorcontrib><creatorcontrib>Ala-Opas, M.</creatorcontrib><creatorcontrib>Kosma, V.M.</creatorcontrib><title>Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>BACKGROUND
p21(waf1/cip1) protein is a cyclin‐dependent kinase inhibitor able to arrest the cell cycle at the G1 phase by inhibiting DNA replication. The expression of p21(waf1/cip1) and its prognostic value in prostate cancer are largely unexplored.
METHODS
We used immunohistochemistry to analyze the expression of p21(waf1/cip1) in 213 prostate cancer cases, and the results were related to other known prognostic factors and patient survival during a long‐term follow‐up.
RESULTS
The expression of p21 (waf1/cip1) protein was significantly associated with high Gleason score (P = 0.001), DNA aneuploidy (P = 0.013), high S‐phase fraction (P = 0.019), and expression of Ki‐67 (P = 0.021) and bcl‐2 (P = 0.001) as well as cyclin A (P = 0.035) and D proteins (P < 0.001). In univariate survival analysis the signal of p21(waf1/cip1) was significantly related to unfavorable prognosis (P = 0.010) both in the entire cohort and in local tumors (P = 0.034). In multivariate analysis, M‐category, clinical T‐category, Gleason score, and patient age were independent prognostic factors. In local tumors the expression of p21(waf1/cip1) together with clinical T‐category and S‐phase fraction were significant independent predictors of cancer related survival.
CONCLUSIONS
The results suggest that the expression of p21(waf1/cip1) protein is associated both with cell proliferation and patient survival in prostate cancer. Prostate 39:8–15, 1999. © 1999 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cyclin-Dependent Kinase Inhibitor p21</subject><subject>Cyclins - biosynthesis</subject><subject>Enzyme Inhibitors - metabolism</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>p21(waf1/cip1)</subject><subject>Prognosis</subject><subject>prostate neoplasm</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNGK00AUhgdR3Lr6CpILkfYi3TNnMkmn6sKS6loo6eKuCt4cJslEsqZJNpO6u2_v1NQqKAgDZxj-883Px9gbDlMOgCfjy2W8nHBQkQ8QyDFXSkEAfCLUnL-ezedny4V_8WF9iadiCtN4_Qr95AEbHTYeshFgBH7ARXTEnlh7DeDIgI_ZEQdEjiGM2Oqia77Wje3LzPuuq63xdJ175q7tjLVlU3tN4bXIx7e64CdZ2fKJ13ZNb8rac8ddba9742W6zkz3lD0qdGXNs_08Zh_fvb2K3_ur9fkyPlv5WSA4-gLDNAAdSsSZApXpMA8ig0oGaiZFbhBRCCmhkFLOhIA0NUrKHHUhEHRqxDF7OXDd_zdbY3valDYzVaVr02wthSrigQoDcSiQuaK2MwW1XbnR3T1xoJ1mop1m2kmjnTT6pZmEIk4zIqeZfmomQUDxmpASx32-L7BNNyb_gzp4dYEX-4C2ma6Kzvkp7e9chGGEkYt9GmK3ZWXu_yr3n27_qjY8OLA_gEvbm7sDWHffKIxEJOlzck5hskiuvvCAFuIHTDCxxA</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Aaltomaa, S.</creator><creator>Lipponen, P.</creator><creator>Eskelinen, M.</creator><creator>Ala-Opas, M.</creator><creator>Kosma, V.M.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer</title><author>Aaltomaa, S. ; Lipponen, P. ; Eskelinen, M. ; Ala-Opas, M. ; Kosma, V.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4312-326b40a65228909ca6d47e29549853de22233550f5558330bbe955d2af320abe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cyclin-Dependent Kinase Inhibitor p21</topic><topic>Cyclins - biosynthesis</topic><topic>Enzyme Inhibitors - metabolism</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>p21(waf1/cip1)</topic><topic>Prognosis</topic><topic>prostate neoplasm</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aaltomaa, S.</creatorcontrib><creatorcontrib>Lipponen, P.</creatorcontrib><creatorcontrib>Eskelinen, M.</creatorcontrib><creatorcontrib>Ala-Opas, M.</creatorcontrib><creatorcontrib>Kosma, V.M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aaltomaa, S.</au><au>Lipponen, P.</au><au>Eskelinen, M.</au><au>Ala-Opas, M.</au><au>Kosma, V.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>39</volume><issue>1</issue><spage>8</spage><epage>15</epage><pages>8-15</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>BACKGROUND
p21(waf1/cip1) protein is a cyclin‐dependent kinase inhibitor able to arrest the cell cycle at the G1 phase by inhibiting DNA replication. The expression of p21(waf1/cip1) and its prognostic value in prostate cancer are largely unexplored.
METHODS
We used immunohistochemistry to analyze the expression of p21(waf1/cip1) in 213 prostate cancer cases, and the results were related to other known prognostic factors and patient survival during a long‐term follow‐up.
RESULTS
The expression of p21 (waf1/cip1) protein was significantly associated with high Gleason score (P = 0.001), DNA aneuploidy (P = 0.013), high S‐phase fraction (P = 0.019), and expression of Ki‐67 (P = 0.021) and bcl‐2 (P = 0.001) as well as cyclin A (P = 0.035) and D proteins (P < 0.001). In univariate survival analysis the signal of p21(waf1/cip1) was significantly related to unfavorable prognosis (P = 0.010) both in the entire cohort and in local tumors (P = 0.034). In multivariate analysis, M‐category, clinical T‐category, Gleason score, and patient age were independent prognostic factors. In local tumors the expression of p21(waf1/cip1) together with clinical T‐category and S‐phase fraction were significant independent predictors of cancer related survival.
CONCLUSIONS
The results suggest that the expression of p21(waf1/cip1) protein is associated both with cell proliferation and patient survival in prostate cancer. Prostate 39:8–15, 1999. © 1999 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10221260</pmid><doi>10.1002/(SICI)1097-0045(19990401)39:1<8::AID-PROS2>3.0.CO;2-N</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0270-4137 |
| ispartof | The Prostate, 1999-04, Vol.39 (1), p.8-15 |
| issn | 0270-4137 1097-0045 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69714964 |
| source | MEDLINE; Wiley Journals |
| subjects | Aged Biological and medical sciences Cyclin-Dependent Kinase Inhibitor p21 Cyclins - biosynthesis Enzyme Inhibitors - metabolism Follow-Up Studies Humans Male Medical sciences Nephrology. Urinary tract diseases p21(waf1/cip1) Prognosis prostate neoplasm Prostatic Neoplasms - metabolism Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Survival Rate Time Factors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T03%3A20%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20value%20and%20expression%20of%20p21(waf1/cip1)%20protein%20in%20prostate%20cancer&rft.jtitle=The%20Prostate&rft.au=Aaltomaa,%20S.&rft.date=1999-04-01&rft.volume=39&rft.issue=1&rft.spage=8&rft.epage=15&rft.pages=8-15&rft.issn=0270-4137&rft.eissn=1097-0045&rft.coden=PRSTDS&rft_id=info:doi/10.1002/(SICI)1097-0045(19990401)39:1%3C8::AID-PROS2%3E3.0.CO;2-N&rft_dat=%3Cproquest_cross%3E69714964%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69714964&rft_id=info:pmid/10221260&rfr_iscdi=true |