Management of patients with concomitant lung cancer and abdominal aortic aneurysm
Abstract Background Management of patients with an abdominal aortic aneurysm (AAA) and malignancy is challenging. We aimed to define the coincidence of AAA and lung cancer and to determine a treatment strategy. Methods The outcomes for patients diagnosed with AAA and lung cancer between 1991 and 200...
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| Veröffentlicht in: | The American journal of surgery 2008-11, Vol.196 (5), p.697-702 |
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| creator | Blochle, Raphael, M.D Lall, Purandath, M.B.B.S Cherr, Gregory S., M.D Harris, Linda M., M.D Dryjski, Maciej L., M.D Hsu, Hwei-Kang, M.D Dosluoglu, Hasan H., M.D |
| description | Abstract Background Management of patients with an abdominal aortic aneurysm (AAA) and malignancy is challenging. We aimed to define the coincidence of AAA and lung cancer and to determine a treatment strategy. Methods The outcomes for patients diagnosed with AAA and lung cancer between 1991 and 2004 at our institution were reviewed retrospectively. Results We identified 75 patients with both lesions among 1,096 AAA and 1,875 lung cancer patients. Survival correlated with cancer stage; only 3 deaths were directly attributable to the patient's AAA. Of 59 patients who did not have AAA repair at the time of cancer diagnosis, 12 were repaired. Twenty-seven of those 59 patients had a 5.0-cm or larger AAA; only 1 patient with a 7.5-cm AAA had a rupture 5 months after thoracotomy and died. Conclusions The co-existence of AAA and lung cancer is not rare; prognosis is poor and largely determined by the lung cancer stage. Open or endovascular repair of AAA rarely is justified in patients with advanced disease unless the AAA is symptomatic or large (>7 cm). Treatment for AAAs greater than 5.5 cm should be based on stage, histology, and patient comorbidities. |
| doi_str_mv | 10.1016/j.amjsurg.2008.07.011 |
| format | Article |
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We aimed to define the coincidence of AAA and lung cancer and to determine a treatment strategy. Methods The outcomes for patients diagnosed with AAA and lung cancer between 1991 and 2004 at our institution were reviewed retrospectively. Results We identified 75 patients with both lesions among 1,096 AAA and 1,875 lung cancer patients. Survival correlated with cancer stage; only 3 deaths were directly attributable to the patient's AAA. Of 59 patients who did not have AAA repair at the time of cancer diagnosis, 12 were repaired. Twenty-seven of those 59 patients had a 5.0-cm or larger AAA; only 1 patient with a 7.5-cm AAA had a rupture 5 months after thoracotomy and died. Conclusions The co-existence of AAA and lung cancer is not rare; prognosis is poor and largely determined by the lung cancer stage. Open or endovascular repair of AAA rarely is justified in patients with advanced disease unless the AAA is symptomatic or large (>7 cm). Treatment for AAAs greater than 5.5 cm should be based on stage, histology, and patient comorbidities.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2008.07.011</identifier><identifier>PMID: 18823617</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abdomen ; Abdominal aortic aneurysm ; Aged ; Aged, 80 and over ; Aortic Aneurysm, Abdominal - complications ; Aortic Aneurysm, Abdominal - mortality ; Aortic Aneurysm, Abdominal - surgery ; Biological and medical sciences ; Cancer therapies ; Concomitant malignancy ; General aspects ; Histology ; Humans ; Lung cancer ; Lung Neoplasms - complications ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Medical sciences ; Middle Aged ; Mortality ; Multivariate analysis ; Neoplasm Staging ; Ostomy ; Pneumology ; Prognosis ; Retrospective Studies ; Risk Factors ; Smoking ; Surgery ; Survival Rate ; Treatment Outcome ; Tumors of the respiratory system and mediastinum</subject><ispartof>The American journal of surgery, 2008-11, Vol.196 (5), p.697-702</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-55a50083226445c5744c2d8dda928cb041f4e6684318402943a510793b4d55073</citedby><cites>FETCH-LOGICAL-c476t-55a50083226445c5744c2d8dda928cb041f4e6684318402943a510793b4d55073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1444576775?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20824452$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18823617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blochle, Raphael, M.D</creatorcontrib><creatorcontrib>Lall, Purandath, M.B.B.S</creatorcontrib><creatorcontrib>Cherr, Gregory S., M.D</creatorcontrib><creatorcontrib>Harris, Linda M., M.D</creatorcontrib><creatorcontrib>Dryjski, Maciej L., M.D</creatorcontrib><creatorcontrib>Hsu, Hwei-Kang, M.D</creatorcontrib><creatorcontrib>Dosluoglu, Hasan H., M.D</creatorcontrib><title>Management of patients with concomitant lung cancer and abdominal aortic aneurysm</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Management of patients with an abdominal aortic aneurysm (AAA) and malignancy is challenging. We aimed to define the coincidence of AAA and lung cancer and to determine a treatment strategy. Methods The outcomes for patients diagnosed with AAA and lung cancer between 1991 and 2004 at our institution were reviewed retrospectively. Results We identified 75 patients with both lesions among 1,096 AAA and 1,875 lung cancer patients. Survival correlated with cancer stage; only 3 deaths were directly attributable to the patient's AAA. Of 59 patients who did not have AAA repair at the time of cancer diagnosis, 12 were repaired. Twenty-seven of those 59 patients had a 5.0-cm or larger AAA; only 1 patient with a 7.5-cm AAA had a rupture 5 months after thoracotomy and died. Conclusions The co-existence of AAA and lung cancer is not rare; prognosis is poor and largely determined by the lung cancer stage. Open or endovascular repair of AAA rarely is justified in patients with advanced disease unless the AAA is symptomatic or large (>7 cm). Treatment for AAAs greater than 5.5 cm should be based on stage, histology, and patient comorbidities.</description><subject>Abdomen</subject><subject>Abdominal aortic aneurysm</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aortic Aneurysm, Abdominal - complications</subject><subject>Aortic Aneurysm, Abdominal - mortality</subject><subject>Aortic Aneurysm, Abdominal - surgery</subject><subject>Biological and medical sciences</subject><subject>Cancer therapies</subject><subject>Concomitant malignancy</subject><subject>General aspects</subject><subject>Histology</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - complications</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Neoplasm Staging</subject><subject>Ostomy</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkttu1DAQhi1ERZfCI4AiIbhLGJ-dGxCqOEmtEAKuLa_jLA45bO2Eat-eWW1Epd70yof5Zub37yHkBYWKAlVvu8oNXV7SrmIApgJdAaWPyIYaXZfUGP6YbACAlbWicE6e5tzhkVLBn5BzjDOuqN6Q79dudLswhHEuprbYuzniNhe3cf5d-Gn00xBnh8F-GXeFd6MPqXBjU7htg6HR9YWb0hw9XoYlHfLwjJy1rs_h-bpekF-fPv68_FJeffv89fLDVemFVnMppZMonDOmhJBeaiE8a0zTuJoZvwVBWxGUMoJTI4DVgjtJQdd8KxopQfML8uZUd5-mmyXk2Q4x-9D3KGRaslW1pkJRjuCre2A3LQmVZ0sF9tZKa4mUPFE-TTmn0Np9ioNLB0vBHh23nV0dt0fHLWiLdmLey7X6sh1Cc5e1WozA6xVw2bu-TehhzP85BoahCIbc-xMX0LS_MSSbPf6FD01Mwc-2meKDUt7dq-D7OEZs-iccQr57tc3Mgv1xHI_jdIABkJoL_g-zs7Qs</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Blochle, Raphael, M.D</creator><creator>Lall, Purandath, M.B.B.S</creator><creator>Cherr, Gregory S., M.D</creator><creator>Harris, Linda M., M.D</creator><creator>Dryjski, Maciej L., M.D</creator><creator>Hsu, Hwei-Kang, M.D</creator><creator>Dosluoglu, Hasan H., M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Management of patients with concomitant lung cancer and abdominal aortic aneurysm</title><author>Blochle, Raphael, M.D ; Lall, Purandath, M.B.B.S ; Cherr, Gregory S., M.D ; Harris, Linda M., M.D ; Dryjski, Maciej L., M.D ; Hsu, Hwei-Kang, M.D ; Dosluoglu, Hasan H., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-55a50083226445c5744c2d8dda928cb041f4e6684318402943a510793b4d55073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdomen</topic><topic>Abdominal aortic aneurysm</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aortic Aneurysm, Abdominal - complications</topic><topic>Aortic Aneurysm, Abdominal - mortality</topic><topic>Aortic Aneurysm, Abdominal - surgery</topic><topic>Biological and medical sciences</topic><topic>Cancer therapies</topic><topic>Concomitant malignancy</topic><topic>General aspects</topic><topic>Histology</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - complications</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Neoplasm Staging</topic><topic>Ostomy</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blochle, Raphael, M.D</creatorcontrib><creatorcontrib>Lall, Purandath, M.B.B.S</creatorcontrib><creatorcontrib>Cherr, Gregory S., M.D</creatorcontrib><creatorcontrib>Harris, Linda M., M.D</creatorcontrib><creatorcontrib>Dryjski, Maciej L., M.D</creatorcontrib><creatorcontrib>Hsu, Hwei-Kang, M.D</creatorcontrib><creatorcontrib>Dosluoglu, Hasan H., M.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blochle, Raphael, M.D</au><au>Lall, Purandath, M.B.B.S</au><au>Cherr, Gregory S., M.D</au><au>Harris, Linda M., M.D</au><au>Dryjski, Maciej L., M.D</au><au>Hsu, Hwei-Kang, M.D</au><au>Dosluoglu, Hasan H., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of patients with concomitant lung cancer and abdominal aortic aneurysm</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>196</volume><issue>5</issue><spage>697</spage><epage>702</epage><pages>697-702</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Abstract Background Management of patients with an abdominal aortic aneurysm (AAA) and malignancy is challenging. We aimed to define the coincidence of AAA and lung cancer and to determine a treatment strategy. Methods The outcomes for patients diagnosed with AAA and lung cancer between 1991 and 2004 at our institution were reviewed retrospectively. Results We identified 75 patients with both lesions among 1,096 AAA and 1,875 lung cancer patients. Survival correlated with cancer stage; only 3 deaths were directly attributable to the patient's AAA. Of 59 patients who did not have AAA repair at the time of cancer diagnosis, 12 were repaired. Twenty-seven of those 59 patients had a 5.0-cm or larger AAA; only 1 patient with a 7.5-cm AAA had a rupture 5 months after thoracotomy and died. Conclusions The co-existence of AAA and lung cancer is not rare; prognosis is poor and largely determined by the lung cancer stage. Open or endovascular repair of AAA rarely is justified in patients with advanced disease unless the AAA is symptomatic or large (>7 cm). Treatment for AAAs greater than 5.5 cm should be based on stage, histology, and patient comorbidities.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18823617</pmid><doi>10.1016/j.amjsurg.2008.07.011</doi><tpages>6</tpages></addata></record> |
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| subjects | Abdomen Abdominal aortic aneurysm Aged Aged, 80 and over Aortic Aneurysm, Abdominal - complications Aortic Aneurysm, Abdominal - mortality Aortic Aneurysm, Abdominal - surgery Biological and medical sciences Cancer therapies Concomitant malignancy General aspects Histology Humans Lung cancer Lung Neoplasms - complications Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - surgery Male Medical sciences Middle Aged Mortality Multivariate analysis Neoplasm Staging Ostomy Pneumology Prognosis Retrospective Studies Risk Factors Smoking Surgery Survival Rate Treatment Outcome Tumors of the respiratory system and mediastinum |
| title | Management of patients with concomitant lung cancer and abdominal aortic aneurysm |
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