Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters : Increase in endothelin-1 production in the heart and beneficial effect of endothelin-A receptor antagonist on survival and cardiac function

We previously reported that chronic endothelin (ET) receptor blockade ameliorated the survival rate and cardiac hemodynamics in rats with chronic heart failure (CHF) due to myocardial infarction. However, it remains unclear whether ET-1 is involved in the pathophysiology of cardiomyopathy, which is...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-04, Vol.99 (16), p.2171-2176
Hauptverfasser:	YAMAUCHI-KOHNO, R, MIYAUCHI, T, HOSHINO, T, KOBAYASHI, T, AIHARA, H, SAKAI, S, YABANA, H, GOTO, K, SUGISHITA, Y, MURATA, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects Cardiology. Vascular system Cardiomyopathies - genetics Cardiomyopathies - physiopathology Cricetinae Endothelin Receptor Antagonists Endothelin-1 - genetics Endothelin-1 - physiology Heart Heart Failure - drug therapy Heart Failure - etiology Heart Failure - physiopathology Heart Rate - drug effects Hemodynamics - drug effects Hemodynamics - physiology Male Medical sciences Myocarditis. Cardiomyopathies Myocardium - metabolism Pyrimidines - pharmacology Pyrimidines - therapeutic use Rats Receptor, Endothelin A Sulfonamides - pharmacology Sulfonamides - therapeutic use Survival Rate Ventricular Function, Left - drug effects Ventricular Function, Right - drug effects
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