p38 Kinase Is Activated in the Alzheimer's Disease Brain
: The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age‐matched normal brain. Intense p...
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| Veröffentlicht in: | Journal of neurochemistry 1999-05, Vol.72 (5), p.2053-2058 |
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| container_title | Journal of neurochemistry |
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| creator | Hensley, Kenneth Floyd, Robert A. Zheng, Nai‐Ying Nael, Raha Robinson, Kent A. Nguyen, Xuan Pye, Quentin N. Stewart, Charles A. Geddes, James Markesbery, William R. Patel, Ela Johnson, Gail V. W. Bing, Guoying |
| description | : The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age‐matched normal brain. Intense phospho‐p38 immunoreactivity was associated with neuritic plaques, neuropil threads, and neurofibrillary tangle‐bearing neurons. The antibody against phosphorylated p38 recognized many of the same structures as an antibody against aberrantly phosphorylated, paired helical filament (PHF) tau, although PHF‐positive tau did not cross‐react with the phospho‐p38 antibody. These findings suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components. |
| doi_str_mv | 10.1046/j.1471-4159.1999.0722053.x |
| format | Article |
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W. ; Bing, Guoying</creator><creatorcontrib>Hensley, Kenneth ; Floyd, Robert A. ; Zheng, Nai‐Ying ; Nael, Raha ; Robinson, Kent A. ; Nguyen, Xuan ; Pye, Quentin N. ; Stewart, Charles A. ; Geddes, James ; Markesbery, William R. ; Patel, Ela ; Johnson, Gail V. W. ; Bing, Guoying</creatorcontrib><description>: The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age‐matched normal brain. Intense phospho‐p38 immunoreactivity was associated with neuritic plaques, neuropil threads, and neurofibrillary tangle‐bearing neurons. The antibody against phosphorylated p38 recognized many of the same structures as an antibody against aberrantly phosphorylated, paired helical filament (PHF) tau, although PHF‐positive tau did not cross‐react with the phospho‐p38 antibody. These findings suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.1999.0722053.x</identifier><identifier>PMID: 10217284</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - enzymology ; Alzheimer Disease - pathology ; Alzheimer's disease ; Antibodies, Monoclonal - immunology ; Blotting, Western ; Brain - enzymology ; Brain - pathology ; Calcium-Calmodulin-Dependent Protein Kinases - metabolism ; Cross Reactions ; Dementia ; Enzyme Activation - physiology ; Female ; Humans ; Immunohistochemistry ; Inflammation ; Male ; Mitogen-Activated Protein Kinases ; p38 kinase ; p38 Mitogen-Activated Protein Kinases ; Phosphorylation ; Reference Values ; Tau ; tau Proteins - metabolism ; Tissue Distribution</subject><ispartof>Journal of neurochemistry, 1999-05, Vol.72 (5), p.2053-2058</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5203-b730551592b93a0443b3ee0ece4ffac73fb4c967260294cf616ae308951f945c3</citedby><cites>FETCH-LOGICAL-c5203-b730551592b93a0443b3ee0ece4ffac73fb4c967260294cf616ae308951f945c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1471-4159.1999.0722053.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1471-4159.1999.0722053.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10217284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hensley, Kenneth</creatorcontrib><creatorcontrib>Floyd, Robert A.</creatorcontrib><creatorcontrib>Zheng, Nai‐Ying</creatorcontrib><creatorcontrib>Nael, Raha</creatorcontrib><creatorcontrib>Robinson, Kent A.</creatorcontrib><creatorcontrib>Nguyen, Xuan</creatorcontrib><creatorcontrib>Pye, Quentin N.</creatorcontrib><creatorcontrib>Stewart, Charles A.</creatorcontrib><creatorcontrib>Geddes, James</creatorcontrib><creatorcontrib>Markesbery, William R.</creatorcontrib><creatorcontrib>Patel, Ela</creatorcontrib><creatorcontrib>Johnson, Gail V. W.</creatorcontrib><creatorcontrib>Bing, Guoying</creatorcontrib><title>p38 Kinase Is Activated in the Alzheimer's Disease Brain</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age‐matched normal brain. Intense phospho‐p38 immunoreactivity was associated with neuritic plaques, neuropil threads, and neurofibrillary tangle‐bearing neurons. The antibody against phosphorylated p38 recognized many of the same structures as an antibody against aberrantly phosphorylated, paired helical filament (PHF) tau, although PHF‐positive tau did not cross‐react with the phospho‐p38 antibody. These findings suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - enzymology</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Blotting, Western</subject><subject>Brain - enzymology</subject><subject>Brain - pathology</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</subject><subject>Cross Reactions</subject><subject>Dementia</subject><subject>Enzyme Activation - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Male</subject><subject>Mitogen-Activated Protein Kinases</subject><subject>p38 kinase</subject><subject>p38 Mitogen-Activated Protein Kinases</subject><subject>Phosphorylation</subject><subject>Reference Values</subject><subject>Tau</subject><subject>tau Proteins - metabolism</subject><subject>Tissue Distribution</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtOwzAQRS0EouXxCyhiAauE8SNOzAaV8ipUsIG15bgT1VWaljiFlq8nUSrEDrGakebMndEh5JRCREHIi1lERUJDQWMVUaVUBAljEPNovUP6P6Nd0gdgLOQgWI8ceD8DoFJIuk96FBhNWCr6JF3yNHhypfEYjHwwsLX7MDVOAlcG9RSDQfE1RTfH6twHN85jy11XxpVHZC83hcfjbT0kb3e3r8OHcPxyPxoOxqGNGfAwSzjEcfMOyxQ3IATPOCKgRZHnxiY8z4RVMmESmBI2l1Qa5JCqmOZKxJYfkrMud1kt3lfoaz133mJRmBIXK6-lSihLqfgTpM0nrEluwMsOtNXC-wpzvazc3FQbTUG3gvVMtxZ1a1G3gvVWsF43yyfbK6tsjpNfq53RBrjqgE9X4OYf0frxedh2_BuZ6Ibg</recordid><startdate>199905</startdate><enddate>199905</enddate><creator>Hensley, Kenneth</creator><creator>Floyd, Robert A.</creator><creator>Zheng, Nai‐Ying</creator><creator>Nael, Raha</creator><creator>Robinson, Kent A.</creator><creator>Nguyen, Xuan</creator><creator>Pye, Quentin N.</creator><creator>Stewart, Charles A.</creator><creator>Geddes, James</creator><creator>Markesbery, William R.</creator><creator>Patel, Ela</creator><creator>Johnson, Gail V. W.</creator><creator>Bing, Guoying</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>199905</creationdate><title>p38 Kinase Is Activated in the Alzheimer's Disease Brain</title><author>Hensley, Kenneth ; Floyd, Robert A. ; Zheng, Nai‐Ying ; Nael, Raha ; Robinson, Kent A. ; Nguyen, Xuan ; Pye, Quentin N. ; Stewart, Charles A. ; Geddes, James ; Markesbery, William R. ; Patel, Ela ; Johnson, Gail V. W. ; Bing, Guoying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5203-b730551592b93a0443b3ee0ece4ffac73fb4c967260294cf616ae308951f945c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - enzymology</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Blotting, Western</topic><topic>Brain - enzymology</topic><topic>Brain - pathology</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</topic><topic>Cross Reactions</topic><topic>Dementia</topic><topic>Enzyme Activation - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Male</topic><topic>Mitogen-Activated Protein Kinases</topic><topic>p38 kinase</topic><topic>p38 Mitogen-Activated Protein Kinases</topic><topic>Phosphorylation</topic><topic>Reference Values</topic><topic>Tau</topic><topic>tau Proteins - metabolism</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hensley, Kenneth</creatorcontrib><creatorcontrib>Floyd, Robert A.</creatorcontrib><creatorcontrib>Zheng, Nai‐Ying</creatorcontrib><creatorcontrib>Nael, Raha</creatorcontrib><creatorcontrib>Robinson, Kent A.</creatorcontrib><creatorcontrib>Nguyen, Xuan</creatorcontrib><creatorcontrib>Pye, Quentin N.</creatorcontrib><creatorcontrib>Stewart, Charles A.</creatorcontrib><creatorcontrib>Geddes, James</creatorcontrib><creatorcontrib>Markesbery, William R.</creatorcontrib><creatorcontrib>Patel, Ela</creatorcontrib><creatorcontrib>Johnson, Gail V. 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W.</au><au>Bing, Guoying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p38 Kinase Is Activated in the Alzheimer's Disease Brain</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1999-05</date><risdate>1999</risdate><volume>72</volume><issue>5</issue><spage>2053</spage><epage>2058</epage><pages>2053-2058</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><abstract>: The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age‐matched normal brain. Intense phospho‐p38 immunoreactivity was associated with neuritic plaques, neuropil threads, and neurofibrillary tangle‐bearing neurons. The antibody against phosphorylated p38 recognized many of the same structures as an antibody against aberrantly phosphorylated, paired helical filament (PHF) tau, although PHF‐positive tau did not cross‐react with the phospho‐p38 antibody. These findings suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10217284</pmid><doi>10.1046/j.1471-4159.1999.0722053.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library; Wiley Online Library Journals Frontfile Complete; IngentaConnect Open Access Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Alzheimer Disease - enzymology Alzheimer Disease - pathology Alzheimer's disease Antibodies, Monoclonal - immunology Blotting, Western Brain - enzymology Brain - pathology Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cross Reactions Dementia Enzyme Activation - physiology Female Humans Immunohistochemistry Inflammation Male Mitogen-Activated Protein Kinases p38 kinase p38 Mitogen-Activated Protein Kinases Phosphorylation Reference Values Tau tau Proteins - metabolism Tissue Distribution |
| title | p38 Kinase Is Activated in the Alzheimer's Disease Brain |
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