eIF4E activity is regulated at multiple levels

A key regulatory step in translation is initiation, or the recruitment of the translational machinery to the 5′ end of mRNA. The 5′ terminus of most mRNAs is demarcated by a m7GpppN cap (where m is a methyl group, and N is any nucleotide). The m7 cap is essential for the translation of most mRNAs, a...

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Veröffentlicht in:	International Journal of Biochemistry and Cell Biology 1999, Vol.31 (1), p.43-57
Hauptverfasser:	Raught, Brian, Gingras, Anne-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	akt/PKB Animals Apoptosis - physiology Cell Division - physiology eIF4E 4E-BP1(PHAS-I) Eukaryotic Initiation Factor-4E FRAP/mTOR Gene Expression Regulation Humans Peptide Initiation Factors - chemistry Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Phosphorylation pI3 kinase Protein Biosynthesis Protein Kinases - metabolism RNA Caps - genetics RNA Caps - metabolism Transcription, Genetic Translation initiation
Online-Zugang:	Volltext
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