DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment

DNA damage sensor proteins are recognized as upstream components of the DNA damage checkpoint signaling pathway and are required for cell cycle control and the induction of apoptosis. hRad9 plays an important role as an upstream regulator of checkpoint signaling. In our previous studies, we confirme...

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Veröffentlicht in:	Oncology reports 2008-11, Vol.20 (5), p.1047-1052
Hauptverfasser:	YUKI, Takeshi, MANIWA, Yoshimasa, DOI, Takefumi, OKADA, Kenji, NISHIO, Wataru, HAYASHI, Yoshitake, OKITA, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell Cycle - physiology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Checkpoint Kinase 1 Flow Cytometry Fluorescent Antibody Technique Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Medical sciences Pneumology Protein Kinases - metabolism RNA, Small Interfering Signal Transduction - physiology Transfection Tumors Tumors of the respiratory system and mediastinum
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