Arteriolar and Venular Vasodilating Properties of Benidipine Hydrochloride, a 1,4-Dihydropyridine Ca2+ Antagonist with Long-Lasting Action, Assessed in Rat Mesenteric Microcirculation
To obtain direct and visible evidence of the arteriolar vasodilating action in vivo of benidipine hydrochloride, a long-lasting and light-resistant Ca antagonist of the 1,4-dihydropyridine type, we continuously recorded changes in the diameter of mesenteric arterioles (10-40 μm) and venules (20-40 μ...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1999-04, Vol.33 (4), p.540-548 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Nakayama, Koichi Horikawa, Naotsugu Ogawa, Tomoko Kohno, Fumika Ishii, Kunio Kubo, Kazuhiro Imabeppu, Susumu |
| description | To obtain direct and visible evidence of the arteriolar vasodilating action in vivo of benidipine hydrochloride, a long-lasting and light-resistant Ca antagonist of the 1,4-dihydropyridine type, we continuously recorded changes in the diameter of mesenteric arterioles (10-40 μm) and venules (20-40 μm) in anesthetized agent-injected Wistar rats by means of digital image processing combined with videomicroscopy. Benidipine injected intravenously brought about a depressor response, and this response persisted much longer than that induced by nifedipine. Benidipine produced a dose-dependent arteriolar vasodilation and a decrease in the blood-flow velocity. It also relaxed the venules during the depressor response, which relaxation was more prominent 1-2 h after the administration. In pithed rats, both pressor response and arteriolar constriction induced by norepinephrine were prevented by benidipine. Benidipine also inhibited adenosine diphosphate (ADP)-induced interruption of arteriolar blood flow. These results suggest that benidipine produced vasodilation in vivo at both the arteriolar and venular levels. The ability of benidipine to prevent microcirculatory disturbance and to produce arteriolar and venular vasodilation seem to account for its long-lasting Ca-antagonistic antihypertensive action. |
| doi_str_mv | 10.1097/00005344-199904000-00005 |
| format | Article |
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Benidipine injected intravenously brought about a depressor response, and this response persisted much longer than that induced by nifedipine. Benidipine produced a dose-dependent arteriolar vasodilation and a decrease in the blood-flow velocity. It also relaxed the venules during the depressor response, which relaxation was more prominent 1-2 h after the administration. In pithed rats, both pressor response and arteriolar constriction induced by norepinephrine were prevented by benidipine. Benidipine also inhibited adenosine diphosphate (ADP)-induced interruption of arteriolar blood flow. These results suggest that benidipine produced vasodilation in vivo at both the arteriolar and venular levels. The ability of benidipine to prevent microcirculatory disturbance and to produce arteriolar and venular vasodilation seem to account for its long-lasting Ca-antagonistic antihypertensive action.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-199904000-00005</identifier><identifier>PMID: 10218723</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins, Inc</publisher><subject>Adenosine Diphosphate - physiology ; Analysis of Variance ; Animals ; Arterioles - drug effects ; Arterioles - physiology ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Blood Vessels - drug effects ; Calcium Channel Blockers - pharmacology ; Cardiovascular system ; Dihydropyridines - pharmacology ; Male ; Medical sciences ; Mesentery - blood supply ; Mesentery - drug effects ; Microcirculation - drug effects ; Pharmacology. Drug treatments ; Platelet Aggregation - drug effects ; Rats ; Rats, Wistar ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology ; Vasodilator agents. 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Benidipine injected intravenously brought about a depressor response, and this response persisted much longer than that induced by nifedipine. Benidipine produced a dose-dependent arteriolar vasodilation and a decrease in the blood-flow velocity. It also relaxed the venules during the depressor response, which relaxation was more prominent 1-2 h after the administration. In pithed rats, both pressor response and arteriolar constriction induced by norepinephrine were prevented by benidipine. Benidipine also inhibited adenosine diphosphate (ADP)-induced interruption of arteriolar blood flow. These results suggest that benidipine produced vasodilation in vivo at both the arteriolar and venular levels. The ability of benidipine to prevent microcirculatory disturbance and to produce arteriolar and venular vasodilation seem to account for its long-lasting Ca-antagonistic antihypertensive action.</description><subject>Adenosine Diphosphate - physiology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Arterioles - drug effects</subject><subject>Arterioles - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood Vessels - drug effects</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cardiovascular system</subject><subject>Dihydropyridines - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesentery - blood supply</subject><subject>Mesentery - drug effects</subject><subject>Microcirculation - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Aggregation - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><subject>Venules - drug effects</subject><subject>Venules - physiology</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ktuu1CAUhonRuMfRVzBcGG-cKhQK7WUdD9tkdjRG921D6eoUZaACzWSezNez3TMebiQkwJ9vHbJ-EMKUvKSkkq_IvArGeUarqiJ8fmV30j20ogVjGSc5u49WhAqS5ZyLK_Qoxm-EUF5I8RBdUZLTUuZshX7WIUEw3qqAlevwLbhpud-q6DtjVTJujz8FP0JIBiL2PX4NznRmNA7w9akLXg_WB9PBBitMNzx7Y4ZFHk-zuEBblb_AtUtq752JCR9NGvDOu322U_Euf62T8W6D6xhh3h02Dn9WCd9ABLe0p_GN0XMlE_S09OTdY_SgVzbCk8u5Rl_fvf2yvc52H99_2Na7TDMhiwykUL2QEnKuOsY4yFLoAvJCEVlIAm3J-0KWeduWrKAge9GKEoRo-Txd0Qu2Rs_Pecfgf0wQU3MwUYO1yoGfYiMquQyzmsHyDM59xhigb8ZgDiqcGkqaxbTmt2nNH9Mu0ho9vdSY2gN0_wSeXZqBZxdARa1sH5TTJv7lJKt4uWD8jB29nacWv9vpCKEZQNk0NP_7M-wX1COwrA</recordid><startdate>199904</startdate><enddate>199904</enddate><creator>Nakayama, Koichi</creator><creator>Horikawa, Naotsugu</creator><creator>Ogawa, Tomoko</creator><creator>Kohno, Fumika</creator><creator>Ishii, Kunio</creator><creator>Kubo, Kazuhiro</creator><creator>Imabeppu, Susumu</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199904</creationdate><title>Arteriolar and Venular Vasodilating Properties of Benidipine Hydrochloride, a 1,4-Dihydropyridine Ca2+ Antagonist with Long-Lasting Action, Assessed in Rat Mesenteric Microcirculation</title><author>Nakayama, Koichi ; Horikawa, Naotsugu ; Ogawa, Tomoko ; Kohno, Fumika ; Ishii, Kunio ; Kubo, Kazuhiro ; Imabeppu, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3675-e76af677e24ad334e786c5e25a07570eb84f5782bb8351e7f6b68e66b43446f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenosine Diphosphate - physiology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Arterioles - drug effects</topic><topic>Arterioles - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood Vessels - drug effects</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Cardiovascular system</topic><topic>Dihydropyridines - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesentery - blood supply</topic><topic>Mesentery - drug effects</topic><topic>Microcirculation - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Aggregation - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><topic>Venules - drug effects</topic><topic>Venules - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakayama, Koichi</creatorcontrib><creatorcontrib>Horikawa, Naotsugu</creatorcontrib><creatorcontrib>Ogawa, Tomoko</creatorcontrib><creatorcontrib>Kohno, Fumika</creatorcontrib><creatorcontrib>Ishii, Kunio</creatorcontrib><creatorcontrib>Kubo, Kazuhiro</creatorcontrib><creatorcontrib>Imabeppu, Susumu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakayama, Koichi</au><au>Horikawa, Naotsugu</au><au>Ogawa, Tomoko</au><au>Kohno, Fumika</au><au>Ishii, Kunio</au><au>Kubo, Kazuhiro</au><au>Imabeppu, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arteriolar and Venular Vasodilating Properties of Benidipine Hydrochloride, a 1,4-Dihydropyridine Ca2+ Antagonist with Long-Lasting Action, Assessed in Rat Mesenteric Microcirculation</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1999-04</date><risdate>1999</risdate><volume>33</volume><issue>4</issue><spage>540</spage><epage>548</epage><pages>540-548</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>To obtain direct and visible evidence of the arteriolar vasodilating action in vivo of benidipine hydrochloride, a long-lasting and light-resistant Ca antagonist of the 1,4-dihydropyridine type, we continuously recorded changes in the diameter of mesenteric arterioles (10-40 μm) and venules (20-40 μm) in anesthetized agent-injected Wistar rats by means of digital image processing combined with videomicroscopy. Benidipine injected intravenously brought about a depressor response, and this response persisted much longer than that induced by nifedipine. Benidipine produced a dose-dependent arteriolar vasodilation and a decrease in the blood-flow velocity. It also relaxed the venules during the depressor response, which relaxation was more prominent 1-2 h after the administration. In pithed rats, both pressor response and arteriolar constriction induced by norepinephrine were prevented by benidipine. Benidipine also inhibited adenosine diphosphate (ADP)-induced interruption of arteriolar blood flow. These results suggest that benidipine produced vasodilation in vivo at both the arteriolar and venular levels. The ability of benidipine to prevent microcirculatory disturbance and to produce arteriolar and venular vasodilation seem to account for its long-lasting Ca-antagonistic antihypertensive action.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10218723</pmid><doi>10.1097/00005344-199904000-00005</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0160-2446 |
| ispartof | Journal of cardiovascular pharmacology, 1999-04, Vol.33 (4), p.540-548 |
| issn | 0160-2446 1533-4023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69710219 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenosine Diphosphate - physiology Analysis of Variance Animals Arterioles - drug effects Arterioles - physiology Biological and medical sciences Blood Flow Velocity - drug effects Blood Vessels - drug effects Calcium Channel Blockers - pharmacology Cardiovascular system Dihydropyridines - pharmacology Male Medical sciences Mesentery - blood supply Mesentery - drug effects Microcirculation - drug effects Pharmacology. Drug treatments Platelet Aggregation - drug effects Rats Rats, Wistar Vasodilation - drug effects Vasodilator Agents - pharmacology Vasodilator agents. Cerebral vasodilators Venules - drug effects Venules - physiology |
| title | Arteriolar and Venular Vasodilating Properties of Benidipine Hydrochloride, a 1,4-Dihydropyridine Ca2+ Antagonist with Long-Lasting Action, Assessed in Rat Mesenteric Microcirculation |
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