Inhibition by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) of Responses to Nitric Oxide-donors in Rat Pulmonary Artery: Influence of the Mechanism of Nitric Oxide Generation

ODQ, (1H‐[1,2,4]oxadiazolo[4,3‐a]quinoxalin‐1‐one, an inhibitor of soluble guanylate cyclase) inhibits vasorelaxant responses to nitric oxide (NO)‐donor drugs, but the extent of the inhibition varies depending on the NO donor studied. The purpose of this study was to test the hypothesis that these v...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 1999-02, Vol.51 (2), p.135-139
Hauptverfasser:	HOMER, KERRY L., FIORE, STEVEN A., WANSTALL, JANET C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Guanylate Cyclase - antagonists & inhibitors Hydrazines - pharmacology In Vitro Techniques Male Medical sciences Molsidomine - analogs & derivatives Molsidomine - pharmacology Nitric Oxide - biosynthesis Nitric Oxide Donors - pharmacology Nitro Compounds - pharmacology Nitrogen Oxides Oxadiazoles - pharmacology Pharmacology. Drug treatments Pulmonary Artery - drug effects Pulmonary Artery - physiology Quinoxalines - pharmacology Rats Rats, Wistar Spermine - analogs & derivatives Spermine - pharmacology Vasodilation - drug effects
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