Chicoric Acid Analogues as HIV-1 Integrase Inhibitors

The present study was undertaken to examine structural features of l-chicoric acid (3) which are important for potency against purified HIV-1 integrase and for reported cytoprotective effects in cell-based systems. Through a progressive series of analogues, it was shown that enantiomeric d-chicoric...

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Veröffentlicht in:	Journal of medicinal chemistry 1999-04, Vol.42 (8), p.1401-1414
Hauptverfasser:	Lin, Zhaiwei, Neamati, Nouri, Zhao, He, Kiryu, Yoshimitsu, Turpin, Jim A, Aberham, Claudia, Strebel, Klaus, Kohn, Kurt, Witvrouw, Myriam, Pannecouque, Christophe, Debyser, Zeger, De Clercq, Erik, Rice, William G, Pommier, Yves, Burke, Terrence R
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Caffeic Acids catechol Cell Line Chicoric acid analogues cytoprotective effects Drug Evaluation, Preclinical HIV Integrase - metabolism HIV Integrase Inhibitors - pharmacology HIV-1 - drug effects HIV-2 - drug effects Human immunodeficiency virus Human immunodeficiency virus 1 Humans integrase L-chicoric acid Medical sciences MT-4 cells Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship Succinates - chemical synthesis Succinates - chemistry Succinates - pharmacology Virus Replication - drug effects
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