Leptin Up-Regulates the Lactogenic Effect of Prolactin in the Bovine Mammary Gland In Vitro
The ability of leptin to up-regulate prolactin action in the mammary gland is well established. We examined the effect of leptin and prolactin on traits associated with lactation. Leptin and prolactin enhanced proliferation (thymidine incorporation) of the mammary gland cells, elevated the cells’ pr...
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| Veröffentlicht in: | Journal of dairy science 2008-11, Vol.91 (11), p.4183-4189 |
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| creator | Feuermann, Y. Shamay, A. Mabjeesh, S.J. |
| description | The ability of leptin to up-regulate prolactin action in the mammary gland is well established. We examined the effect of leptin and prolactin on traits associated with lactation. Leptin and prolactin enhanced proliferation (thymidine incorporation) of the mammary gland cells, elevated the cells’ proliferation in a dose-responsive manner, and synergized to elevate the expression of amino acid metabolism via a 90% increase in aminopeptidase N expression. Leptin and prolactin decreased apoptosis (decreased caspase-3 expression by 60%) in the same manner. Leptin enhanced the effect of prolactin on all of these processes in bovine mammary explants. Leptin and prolactin regulated mTOR (mammalian target of rapamycin) by increasing expression by 66%, which is one of the signal-transduction junctions involved in the regulation of proliferation, apoptosis, and protein synthesis. These findings support the hypothesis that leptin up-regulates prolactin action in the bovine mammary gland. |
| doi_str_mv | 10.3168/jds.2008-0988 |
| format | Article |
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We examined the effect of leptin and prolactin on traits associated with lactation. Leptin and prolactin enhanced proliferation (thymidine incorporation) of the mammary gland cells, elevated the cells’ proliferation in a dose-responsive manner, and synergized to elevate the expression of amino acid metabolism via a 90% increase in aminopeptidase N expression. Leptin and prolactin decreased apoptosis (decreased caspase-3 expression by 60%) in the same manner. Leptin enhanced the effect of prolactin on all of these processes in bovine mammary explants. Leptin and prolactin regulated mTOR (mammalian target of rapamycin) by increasing expression by 66%, which is one of the signal-transduction junctions involved in the regulation of proliferation, apoptosis, and protein synthesis. These findings support the hypothesis that leptin up-regulates prolactin action in the bovine mammary gland.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.2008-0988</identifier><identifier>PMID: 18946122</identifier><identifier>CODEN: JDSCAE</identifier><language>eng</language><publisher>Savoy, IL: Elsevier Inc</publisher><subject>amino acid metabolism ; aminopeptidase N/CD13 ; Animal productions ; Animals ; apoptosis ; Apoptosis - drug effects ; biochemical pathways ; Biological and medical sciences ; Cattle ; CD13 Antigens - metabolism ; cell proliferation ; Cell Proliferation - drug effects ; cows ; dosage ; dose response ; Female ; Food industries ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Enzymologic - drug effects ; in vitro studies ; lactation ; leptin ; Leptin - pharmacology ; mammary glands ; Mammary Glands, Animal - cytology ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - enzymology ; Milk and cheese industries. Ice creams ; milk synthesis ; prolactin ; Prolactin - pharmacology ; Protein Kinases - metabolism ; protein synthesis ; signal transduction ; synergism ; Terrestrial animal productions ; tissue culture ; TOR Serine-Threonine Kinases ; Up-Regulation - drug effects ; Vertebrates</subject><ispartof>Journal of dairy science, 2008-11, Vol.91 (11), p.4183-4189</ispartof><rights>2008 American Dairy Science Association</rights><rights>2008 INIST-CNRS</rights><rights>Copyright American Dairy Science Association Nov 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-3984d8c378758b0b99da8f7af93c12bfd2ac58d1fdb8accd07149eee6caf3f2d3</citedby><cites>FETCH-LOGICAL-c491t-3984d8c378758b0b99da8f7af93c12bfd2ac58d1fdb8accd07149eee6caf3f2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3168/jds.2008-0988$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20792188$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18946122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feuermann, Y.</creatorcontrib><creatorcontrib>Shamay, A.</creatorcontrib><creatorcontrib>Mabjeesh, S.J.</creatorcontrib><title>Leptin Up-Regulates the Lactogenic Effect of Prolactin in the Bovine Mammary Gland In Vitro</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>The ability of leptin to up-regulate prolactin action in the mammary gland is well established. We examined the effect of leptin and prolactin on traits associated with lactation. Leptin and prolactin enhanced proliferation (thymidine incorporation) of the mammary gland cells, elevated the cells’ proliferation in a dose-responsive manner, and synergized to elevate the expression of amino acid metabolism via a 90% increase in aminopeptidase N expression. Leptin and prolactin decreased apoptosis (decreased caspase-3 expression by 60%) in the same manner. Leptin enhanced the effect of prolactin on all of these processes in bovine mammary explants. Leptin and prolactin regulated mTOR (mammalian target of rapamycin) by increasing expression by 66%, which is one of the signal-transduction junctions involved in the regulation of proliferation, apoptosis, and protein synthesis. These findings support the hypothesis that leptin up-regulates prolactin action in the bovine mammary gland.</description><subject>amino acid metabolism</subject><subject>aminopeptidase N/CD13</subject><subject>Animal productions</subject><subject>Animals</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>biochemical pathways</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>CD13 Antigens - metabolism</subject><subject>cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>cows</subject><subject>dosage</subject><subject>dose response</subject><subject>Female</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Enzymologic - drug effects</subject><subject>in vitro studies</subject><subject>lactation</subject><subject>leptin</subject><subject>Leptin - pharmacology</subject><subject>mammary glands</subject><subject>Mammary Glands, Animal - cytology</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - enzymology</subject><subject>Milk and cheese industries. Ice creams</subject><subject>milk synthesis</subject><subject>prolactin</subject><subject>Prolactin - pharmacology</subject><subject>Protein Kinases - metabolism</subject><subject>protein synthesis</subject><subject>signal transduction</subject><subject>synergism</subject><subject>Terrestrial animal productions</subject><subject>tissue culture</subject><subject>TOR Serine-Threonine Kinases</subject><subject>Up-Regulation - drug effects</subject><subject>Vertebrates</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp10M-L1DAUB_AgijuuHr1qENRT17z0V3LUZV0XRhR1vHgIafIyk6HTjEm74n9vagcFQVooKR--ee9LyGNgFyU04tXepgvOmCiYFOIOWUHN66IEKe6SFWOcF6xk_Iw8SGmfj8BZfZ-cgZBVA5yvyLc1Hkc_0M2x-ITbqdcjJjrukK61GcMWB2_olXNoRhoc_RhDn_9nn99ZvQm3fkD6Xh8OOv6k170eLL0Z6Fc_xvCQ3HO6T_jo9D0nm7dXXy7fFesP1zeXr9eFqSSMRSlFZYUpW9HWomOdlFYL12onSwO8c5ZrUwsLznZCG2NZC5VExMZoVzpuy3PyYsk9xvB9wjSqg08G-zwMhimpRrYsL8wyfPYP3IcpDnk2BbIWuUaoMioWZGJIKaJTx-jn7RQwNVeucuVqrlzNlWf_5BQ6dQe0f_Wp4wyen4BORvcu6sH49Mdx1koOv4NeLm7nt7sfPqJKB933ORbmKyUoAFWBKLN8uking9LbmNM2nzmDkkHdNvnJol0E5t5vPUaVjMfBoM25ZlQ2-P-s8wtxJbI0</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Feuermann, Y.</creator><creator>Shamay, A.</creator><creator>Mabjeesh, S.J.</creator><general>Elsevier Inc</general><general>American Dairy Science Association</general><general>Am Dairy Sci Assoc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Leptin Up-Regulates the Lactogenic Effect of Prolactin in the Bovine Mammary Gland In Vitro</title><author>Feuermann, Y. ; Shamay, A. ; Mabjeesh, S.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-3984d8c378758b0b99da8f7af93c12bfd2ac58d1fdb8accd07149eee6caf3f2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>amino acid metabolism</topic><topic>aminopeptidase N/CD13</topic><topic>Animal productions</topic><topic>Animals</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>biochemical pathways</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>CD13 Antigens - metabolism</topic><topic>cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>cows</topic><topic>dosage</topic><topic>dose response</topic><topic>Female</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Enzymologic - drug effects</topic><topic>in vitro studies</topic><topic>lactation</topic><topic>leptin</topic><topic>Leptin - pharmacology</topic><topic>mammary glands</topic><topic>Mammary Glands, Animal - cytology</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - enzymology</topic><topic>Milk and cheese industries. Ice creams</topic><topic>milk synthesis</topic><topic>prolactin</topic><topic>Prolactin - pharmacology</topic><topic>Protein Kinases - metabolism</topic><topic>protein synthesis</topic><topic>signal transduction</topic><topic>synergism</topic><topic>Terrestrial animal productions</topic><topic>tissue culture</topic><topic>TOR Serine-Threonine Kinases</topic><topic>Up-Regulation - drug effects</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feuermann, Y.</creatorcontrib><creatorcontrib>Shamay, A.</creatorcontrib><creatorcontrib>Mabjeesh, S.J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feuermann, Y.</au><au>Shamay, A.</au><au>Mabjeesh, S.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin Up-Regulates the Lactogenic Effect of Prolactin in the Bovine Mammary Gland In Vitro</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>91</volume><issue>11</issue><spage>4183</spage><epage>4189</epage><pages>4183-4189</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><coden>JDSCAE</coden><abstract>The ability of leptin to up-regulate prolactin action in the mammary gland is well established. We examined the effect of leptin and prolactin on traits associated with lactation. Leptin and prolactin enhanced proliferation (thymidine incorporation) of the mammary gland cells, elevated the cells’ proliferation in a dose-responsive manner, and synergized to elevate the expression of amino acid metabolism via a 90% increase in aminopeptidase N expression. Leptin and prolactin decreased apoptosis (decreased caspase-3 expression by 60%) in the same manner. Leptin enhanced the effect of prolactin on all of these processes in bovine mammary explants. Leptin and prolactin regulated mTOR (mammalian target of rapamycin) by increasing expression by 66%, which is one of the signal-transduction junctions involved in the regulation of proliferation, apoptosis, and protein synthesis. These findings support the hypothesis that leptin up-regulates prolactin action in the bovine mammary gland.</abstract><cop>Savoy, IL</cop><pub>Elsevier Inc</pub><pmid>18946122</pmid><doi>10.3168/jds.2008-0988</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | amino acid metabolism aminopeptidase N/CD13 Animal productions Animals apoptosis Apoptosis - drug effects biochemical pathways Biological and medical sciences Cattle CD13 Antigens - metabolism cell proliferation Cell Proliferation - drug effects cows dosage dose response Female Food industries Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - drug effects in vitro studies lactation leptin Leptin - pharmacology mammary glands Mammary Glands, Animal - cytology Mammary Glands, Animal - drug effects Mammary Glands, Animal - enzymology Milk and cheese industries. Ice creams milk synthesis prolactin Prolactin - pharmacology Protein Kinases - metabolism protein synthesis signal transduction synergism Terrestrial animal productions tissue culture TOR Serine-Threonine Kinases Up-Regulation - drug effects Vertebrates |
| title | Leptin Up-Regulates the Lactogenic Effect of Prolactin in the Bovine Mammary Gland In Vitro |
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