Minimization of Recombinant Human Flt3 Ligand Aggregation at the Tm Plateau: A Matter of Thermal Reversibility

This study elucidates the importance of thermal reversibility as it pertains to the minimization of recombinant human Flt3 ligand aggregation and its potential role for determining solution conditions that can achieve the greatest long-term storage stability. Both thermal reversibility and Tm were e...

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Veröffentlicht in:	Biochemistry (Easton) 1999-04, Vol.38 (16), p.5241-5247
Hauptverfasser:	REMMELE, Richard L., BHAT, Saraswaty D., PHAN, Duke H., GOMBOTZ, Wayne R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calorimetry, Differential Scanning Cell Line Circular Dichroism Electrophoresis, Polyacrylamide Gel Hot Temperature Humans Hydrogen-Ion Concentration Ligands Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Mice Oxidation-Reduction Protein Conformation Protein Denaturation Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sodium Dodecyl Sulfate Temperature
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