Human complement regulatory proteins protect swine lungs from xenogeneic injury

Background. Pulmonary xenotransplantation is not possible because of hyperacute lung injury, the pathogenesis of which is unknown. This study evaluates complement-dependent pathways of pulmonary injury during heterologous perfusion of swine lungs. Methods. Lungs from unmodified swine and swine expre...

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Veröffentlicht in:	The Annals of thoracic surgery 1999-03, Vol.67 (3), p.769-775
Hauptverfasser:	Yeatman, Mark, Daggett, C.William, Lau, Christine L., Byrne, Guerard W., Logan, John S., Platt, Jeffrey L., Davis, R.Duane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood CD55 Antigens - metabolism CD55 Antigens - physiology CD59 Antigens - metabolism CD59 Antigens - physiology Complement System Proteins - physiology Extracorporeal Circulation Graft Rejection - pathology Graft Rejection - physiopathology Humans In Vitro Techniques Lung - metabolism Lung - pathology Lung Transplantation Medical sciences Papio Perfusion Pulmonary Circulation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the respiratory system Swine Transplantation, Heterologous
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