In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the on-line monitoring of melatonin in rat
Liquid chromatography/tandem mass spectrometry (LC/MS/MS) has been coupled to in vivo microdialysis for on‐line monitoring of melatonin in a freely moving rat for a period of 15 hours. A microdialysis probe was surgically implanted into the jugular vein of the rat, and deionized water was used as th...
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| Veröffentlicht in: | Rapid communications in mass spectrometry 1999-03, Vol.13 (5), p.407-411 |
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| creator | Wong, Philip S. H. Yoshioka, K. Xie, F. Kissinger, P. T. |
| description | Liquid chromatography/tandem mass spectrometry (LC/MS/MS) has been coupled to in vivo microdialysis for on‐line monitoring of melatonin in a freely moving rat for a period of 15 hours. A microdialysis probe was surgically implanted into the jugular vein of the rat, and deionized water was used as the perfusion medium at a flow rate of 1.0 µL/min. Microdialysis samples were collected in an on‐line injector with sample injection every 30 minutes. Melatonin was dosed by intraperitoneal (i.p.) injection and then monitored by microdialysis/LC/MS/MS. The whole experiment, including the microdialysis sampling and sample injection into the LC/MS system, was fully automated. Metabolites of melatonin were identified off‐line by LC/MS
n
experiments. Two metabolites were identified as 6‐hydroxymelatonin and cyclic 2‐hydroxymelatonin, consistent with ones found previously in the literature. Copyright © 1999 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1097-0231(19990315)13:5<407::AID-RCM500>3.0.CO;2-I |
| format | Article |
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experiments. Two metabolites were identified as 6‐hydroxymelatonin and cyclic 2‐hydroxymelatonin, consistent with ones found previously in the literature. Copyright © 1999 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-4198</identifier><identifier>EISSN: 1097-0231</identifier><identifier>DOI: 10.1002/(SICI)1097-0231(19990315)13:5<407::AID-RCM500>3.0.CO;2-I</identifier><identifier>PMID: 10209876</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biotransformation ; Calibration ; Chromatography, Liquid ; Injections, Intraperitoneal ; Male ; Mass Spectrometry ; Melatonin - analogs & derivatives ; Melatonin - analysis ; Melatonin - pharmacokinetics ; Microdialysis ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Rapid communications in mass spectrometry, 1999-03, Vol.13 (5), p.407-411</ispartof><rights>Copyright © 1999 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4750-26c9e079accf6812c6c2721f3fffffef33b46008f59c02747b4cbf072019c7a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0231%2819990315%2913%3A5%3C407%3A%3AAID-RCM500%3E3.0.CO%3B2-I$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0231%2819990315%2913%3A5%3C407%3A%3AAID-RCM500%3E3.0.CO%3B2-I$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10209876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Philip S. H.</creatorcontrib><creatorcontrib>Yoshioka, K.</creatorcontrib><creatorcontrib>Xie, F.</creatorcontrib><creatorcontrib>Kissinger, P. T.</creatorcontrib><title>In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the on-line monitoring of melatonin in rat</title><title>Rapid communications in mass spectrometry</title><addtitle>Rapid Commun. Mass Spectrom</addtitle><description>Liquid chromatography/tandem mass spectrometry (LC/MS/MS) has been coupled to in vivo microdialysis for on‐line monitoring of melatonin in a freely moving rat for a period of 15 hours. A microdialysis probe was surgically implanted into the jugular vein of the rat, and deionized water was used as the perfusion medium at a flow rate of 1.0 µL/min. Microdialysis samples were collected in an on‐line injector with sample injection every 30 minutes. Melatonin was dosed by intraperitoneal (i.p.) injection and then monitored by microdialysis/LC/MS/MS. The whole experiment, including the microdialysis sampling and sample injection into the LC/MS system, was fully automated. Metabolites of melatonin were identified off‐line by LC/MS
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experiments. Two metabolites were identified as 6‐hydroxymelatonin and cyclic 2‐hydroxymelatonin, consistent with ones found previously in the literature. Copyright © 1999 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Biotransformation</subject><subject>Calibration</subject><subject>Chromatography, Liquid</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Melatonin - analogs & derivatives</subject><subject>Melatonin - analysis</subject><subject>Melatonin - pharmacokinetics</subject><subject>Microdialysis</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0951-4198</issn><issn>1097-0231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFke-L0zAYx4so3pz-C5JXcvei25OkbZYp4lG9rXg68AeKbx6yLL3lbJtd0p32v7ej8xAUDIHAkyefJ3w_UfSKwoQCsOnpxyIvzihIEQPj9JRKKYHT9IzyefoiATGfnxev4w_5uxTgJZ_AJF89Z3FxLxrdPbofjUCmNE6onJ1Ej0K4BqA0ZfAwOqHAQM5ENopC0ZBbe-tIbbV3G6uqLtgwrezN3m6I3npXq9ZdebXbdtNWNRtTk1qFQMLO6La_Na3vSOk8abeGuCaubGNI7RrbOm-bK-JKUpuqZzS2If32qn0cPShVFcyT4zmOPl-8-ZQv48vVosjPL2OdiBRilmlpQEildZnNKNOZZoLRkpeHZUrO10kGMCtTqYGJRKwTvS5BMKBSC0X5OHo2cHfe3exNaLG2QZuqUo1x-4CZFJDO-qzG0dehsY8gBG9K3HlbK98hBTwIQTwIwUO2eMgWfwtByjHFXghiLwQHIcgRMF8hw6JHPz3-Yb-uzeYP8GCgb_g2NPywlen-Gvzfuf8ce6z08HiA29Can3dw5b9jJrhI8cv7BS4FWy4oXOBb_guCDLgw</recordid><startdate>19990315</startdate><enddate>19990315</enddate><creator>Wong, Philip S. H.</creator><creator>Yoshioka, K.</creator><creator>Xie, F.</creator><creator>Kissinger, P. T.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990315</creationdate><title>In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the on-line monitoring of melatonin in rat</title><author>Wong, Philip S. H. ; Yoshioka, K. ; Xie, F. ; Kissinger, P. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4750-26c9e079accf6812c6c2721f3fffffef33b46008f59c02747b4cbf072019c7a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biotransformation</topic><topic>Calibration</topic><topic>Chromatography, Liquid</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Melatonin - analogs & derivatives</topic><topic>Melatonin - analysis</topic><topic>Melatonin - pharmacokinetics</topic><topic>Microdialysis</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Philip S. H.</creatorcontrib><creatorcontrib>Yoshioka, K.</creatorcontrib><creatorcontrib>Xie, F.</creatorcontrib><creatorcontrib>Kissinger, P. T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rapid communications in mass spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Philip S. H.</au><au>Yoshioka, K.</au><au>Xie, F.</au><au>Kissinger, P. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the on-line monitoring of melatonin in rat</atitle><jtitle>Rapid communications in mass spectrometry</jtitle><addtitle>Rapid Commun. Mass Spectrom</addtitle><date>1999-03-15</date><risdate>1999</risdate><volume>13</volume><issue>5</issue><spage>407</spage><epage>411</epage><pages>407-411</pages><issn>0951-4198</issn><eissn>1097-0231</eissn><abstract>Liquid chromatography/tandem mass spectrometry (LC/MS/MS) has been coupled to in vivo microdialysis for on‐line monitoring of melatonin in a freely moving rat for a period of 15 hours. A microdialysis probe was surgically implanted into the jugular vein of the rat, and deionized water was used as the perfusion medium at a flow rate of 1.0 µL/min. Microdialysis samples were collected in an on‐line injector with sample injection every 30 minutes. Melatonin was dosed by intraperitoneal (i.p.) injection and then monitored by microdialysis/LC/MS/MS. The whole experiment, including the microdialysis sampling and sample injection into the LC/MS system, was fully automated. Metabolites of melatonin were identified off‐line by LC/MS
n
experiments. Two metabolites were identified as 6‐hydroxymelatonin and cyclic 2‐hydroxymelatonin, consistent with ones found previously in the literature. Copyright © 1999 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>10209876</pmid><doi>10.1002/(SICI)1097-0231(19990315)13:5<407::AID-RCM500>3.0.CO;2-I</doi><tpages>5</tpages></addata></record> |
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| ispartof | Rapid communications in mass spectrometry, 1999-03, Vol.13 (5), p.407-411 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biotransformation Calibration Chromatography, Liquid Injections, Intraperitoneal Male Mass Spectrometry Melatonin - analogs & derivatives Melatonin - analysis Melatonin - pharmacokinetics Microdialysis Rats Rats, Sprague-Dawley |
| title | In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the on-line monitoring of melatonin in rat |
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