Absorption and disposition of a tripeptoid and a tetrapeptide in the rat

The present study is concerned with the absorption and disposition of a tripeptoid (N‐substituted glycine derivative) and a tetrapeptide in the rat. The two compounds have similar backbone structures but differ with respect to the presence or absence of peptide bond. [3H]tripeptoid and [3H]tetrapept...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 1999-03, Vol.20 (2), p.69-75
Hauptverfasser:	Wang, Yanfeng, Lin, Hanford, Tullman, Robert, Jewell Jr, Charles F., Weetall, Marla L., Tse, Francis L.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption absorptive clearance Administration, Oral Animals Biological and medical sciences disposition General pharmacology Glycine - administration & dosage Glycine - analogs & derivatives Glycine - pharmacokinetics Intestinal Absorption Male Medical sciences Oligopeptides - administration & dosage Oligopeptides - pharmacokinetics peptide peptoid Peptoids permeability Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Structure-Activity Relationship Tissue Distribution Tritium
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