Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies
Following the success of the NINCDS-ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria. To assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the pr...
Gespeichert in:
| Veröffentlicht in: | British journal of psychiatry 1999-01, Vol.174 (1), p.45-50 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 50 |
|---|---|
| container_issue | 1 |
| container_start_page | 45 |
| container_title | British journal of psychiatry |
| container_volume | 174 |
| creator | Holmes, Clive Cairns, Nigel Lantos, Peter L. Mann, Anthony |
| description | Following the success of the NINCDS-ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria.
To assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate.
A community based post-mortem study.
Mixed pathologies were common (33.8%). The high specificities obtained for the CDLB and NINDS-AIREN criteria (1.00 and 0.95, respectively) were associated with low sensitivities (0.22 and 0.43, respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values.
Current clinical diagnostic criteria are good at detecting pathology per se but not at detecting pure pathology. A large proportion of subjects from the general population fulfilling probable CDLB, probable NINCDS-ADRDA or probable NINDS-AIREN will have mixed pathologies. |
| doi_str_mv | 10.1192/bjp.174.1.45 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69700749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1192_bjp_174_1_45</cupid><sourcerecordid>69700749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-8082caff71906d2af3bdae05822f8f9c43b112c1e6e2ebd47147dbe5d38b1fe63</originalsourceid><addsrcrecordid>eNptkcuLFDEQxoMo7rh68ywBwb1st6l0utN9XBZXhQEv6jXkUdnO0I8x6d5h_OuNzMAuInUoCn711eMj5C2wEqDjH81uX4IUJZSifkY2ICQvQDT1c7JhjMkCeM0uyKuUdrmsBJcvyQUwDgA125Dppx6CC8uRzp7aNUacFmqHMAWrB2pjWDAGTf0c6c3wu8cwYrxK1IWEOuE1fdDJroOO1OGYWzOqJ_dYHMLS0y0ejtTMLmB6TV54PSR8c86X5Mfdp--3X4rtt89fb2-2ha1ktxQta7nV3kvoWOO49pVxGlndcu5b31lRGQBuARvkaJyQ-WpnsHZVa8BjU12SDyfdfZx_rZgWNYZkcRj0hPOaVNPJ_BvRZfD9P-BuXuOUd1O8artKihyZuj5RNs4pRfRqH8Oo41EBU39dUNkFlV1QoESd8Xdn0dWM6J7Ap7dngJ6APtz3hxBRRbtPR9s_1SjPI_VoYnD3-LjZf4f-AZvInio</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2389374747</pqid></control><display><type>article</type><title>Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies</title><source>MEDLINE</source><source>Cambridge Journals</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><creator>Holmes, Clive ; Cairns, Nigel ; Lantos, Peter L. ; Mann, Anthony</creator><creatorcontrib>Holmes, Clive ; Cairns, Nigel ; Lantos, Peter L. ; Mann, Anthony</creatorcontrib><description>Following the success of the NINCDS-ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria.
To assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate.
A community based post-mortem study.
Mixed pathologies were common (33.8%). The high specificities obtained for the CDLB and NINDS-AIREN criteria (1.00 and 0.95, respectively) were associated with low sensitivities (0.22 and 0.43, respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values.
Current clinical diagnostic criteria are good at detecting pathology per se but not at detecting pure pathology. A large proportion of subjects from the general population fulfilling probable CDLB, probable NINCDS-ADRDA or probable NINDS-AIREN will have mixed pathologies.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.174.1.45</identifier><identifier>PMID: 10211150</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease - pathology ; Alzheimer's disease ; Autopsy ; Dementia ; Dementia disorders ; Dementia, Vascular - pathology ; Female ; Humans ; Lewy bodies ; Lewy Bodies - pathology ; Male ; Middle Aged ; Neurodegenerative diseases ; Pathology ; Predictive Value of Tests ; Sensitivity and Specificity ; Vascular dementia</subject><ispartof>British journal of psychiatry, 1999-01, Vol.174 (1), p.45-50</ispartof><rights>Copyright © 1999 The Royal College of Psychiatrists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-8082caff71906d2af3bdae05822f8f9c43b112c1e6e2ebd47147dbe5d38b1fe63</citedby><cites>FETCH-LOGICAL-c379t-8082caff71906d2af3bdae05822f8f9c43b112c1e6e2ebd47147dbe5d38b1fe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007125000152006/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,12826,27903,27904,30978,55606</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10211150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmes, Clive</creatorcontrib><creatorcontrib>Cairns, Nigel</creatorcontrib><creatorcontrib>Lantos, Peter L.</creatorcontrib><creatorcontrib>Mann, Anthony</creatorcontrib><title>Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>Following the success of the NINCDS-ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria.
To assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate.
A community based post-mortem study.
Mixed pathologies were common (33.8%). The high specificities obtained for the CDLB and NINDS-AIREN criteria (1.00 and 0.95, respectively) were associated with low sensitivities (0.22 and 0.43, respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values.
Current clinical diagnostic criteria are good at detecting pathology per se but not at detecting pure pathology. A large proportion of subjects from the general population fulfilling probable CDLB, probable NINCDS-ADRDA or probable NINDS-AIREN will have mixed pathologies.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Autopsy</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Dementia, Vascular - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Lewy bodies</subject><subject>Lewy Bodies - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurodegenerative diseases</subject><subject>Pathology</subject><subject>Predictive Value of Tests</subject><subject>Sensitivity and Specificity</subject><subject>Vascular dementia</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkcuLFDEQxoMo7rh68ywBwb1st6l0utN9XBZXhQEv6jXkUdnO0I8x6d5h_OuNzMAuInUoCn711eMj5C2wEqDjH81uX4IUJZSifkY2ICQvQDT1c7JhjMkCeM0uyKuUdrmsBJcvyQUwDgA125Dppx6CC8uRzp7aNUacFmqHMAWrB2pjWDAGTf0c6c3wu8cwYrxK1IWEOuE1fdDJroOO1OGYWzOqJ_dYHMLS0y0ejtTMLmB6TV54PSR8c86X5Mfdp--3X4rtt89fb2-2ha1ktxQta7nV3kvoWOO49pVxGlndcu5b31lRGQBuARvkaJyQ-WpnsHZVa8BjU12SDyfdfZx_rZgWNYZkcRj0hPOaVNPJ_BvRZfD9P-BuXuOUd1O8artKihyZuj5RNs4pRfRqH8Oo41EBU39dUNkFlV1QoESd8Xdn0dWM6J7Ap7dngJ6APtz3hxBRRbtPR9s_1SjPI_VoYnD3-LjZf4f-AZvInio</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Holmes, Clive</creator><creator>Cairns, Nigel</creator><creator>Lantos, Peter L.</creator><creator>Mann, Anthony</creator><general>Cambridge University Press</general><general>RCP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies</title><author>Holmes, Clive ; Cairns, Nigel ; Lantos, Peter L. ; Mann, Anthony</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-8082caff71906d2af3bdae05822f8f9c43b112c1e6e2ebd47147dbe5d38b1fe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Autopsy</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Dementia, Vascular - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Lewy bodies</topic><topic>Lewy Bodies - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurodegenerative diseases</topic><topic>Pathology</topic><topic>Predictive Value of Tests</topic><topic>Sensitivity and Specificity</topic><topic>Vascular dementia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmes, Clive</creatorcontrib><creatorcontrib>Cairns, Nigel</creatorcontrib><creatorcontrib>Lantos, Peter L.</creatorcontrib><creatorcontrib>Mann, Anthony</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database (ProQuest)</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmes, Clive</au><au>Cairns, Nigel</au><au>Lantos, Peter L.</au><au>Mann, Anthony</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>1999-01</date><risdate>1999</risdate><volume>174</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>Following the success of the NINCDS-ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria.
To assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate.
A community based post-mortem study.
Mixed pathologies were common (33.8%). The high specificities obtained for the CDLB and NINDS-AIREN criteria (1.00 and 0.95, respectively) were associated with low sensitivities (0.22 and 0.43, respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values.
Current clinical diagnostic criteria are good at detecting pathology per se but not at detecting pure pathology. A large proportion of subjects from the general population fulfilling probable CDLB, probable NINCDS-ADRDA or probable NINDS-AIREN will have mixed pathologies.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>10211150</pmid><doi>10.1192/bjp.174.1.45</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1250 |
| ispartof | British journal of psychiatry, 1999-01, Vol.174 (1), p.45-50 |
| issn | 0007-1250 1472-1465 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69700749 |
| source | MEDLINE; Cambridge Journals; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Aged Aged, 80 and over Alzheimer Disease - pathology Alzheimer's disease Autopsy Dementia Dementia disorders Dementia, Vascular - pathology Female Humans Lewy bodies Lewy Bodies - pathology Male Middle Aged Neurodegenerative diseases Pathology Predictive Value of Tests Sensitivity and Specificity Vascular dementia |
| title | Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T15%3A30%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Validity%20of%20current%20clinical%20criteria%20for%20Alzheimer's%20disease,%20vascular%20dementia%20and%20dementia%20with%20Lewy%20bodies&rft.jtitle=British%20journal%20of%20psychiatry&rft.au=Holmes,%20Clive&rft.date=1999-01&rft.volume=174&rft.issue=1&rft.spage=45&rft.epage=50&rft.pages=45-50&rft.issn=0007-1250&rft.eissn=1472-1465&rft_id=info:doi/10.1192/bjp.174.1.45&rft_dat=%3Cproquest_cross%3E69700749%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2389374747&rft_id=info:pmid/10211150&rft_cupid=10_1192_bjp_174_1_45&rfr_iscdi=true |