Trends in antihypertensive drug advertising, 1985-1996
Over the past decade, calcium channel blockers (CCBs) and ACE inhibitors have been used increasingly in the treatment of hypertension. In contrast, beta-blocker and diuretic use has decreased. It has been suggested that pharmaceutical marketing has influenced these prescribing patterns. No objective...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1999-04, Vol.99 (15), p.2055-2057 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | WANG, T. J AUSIELLO, J. C STAFFORD, R. S |
| description | Over the past decade, calcium channel blockers (CCBs) and ACE inhibitors have been used increasingly in the treatment of hypertension. In contrast, beta-blocker and diuretic use has decreased. It has been suggested that pharmaceutical marketing has influenced these prescribing patterns. No objective analysis of advertising for antihypertensive therapies exists, however.
We reviewed the January, April, July, and October issues of the New England Journal of Medicine from 1985 to 1996 (210 issues). The intensity of drug promotion was measured as the proportion of advertising pages used to promote a given medication. Statistical analyses used the chi2 test for trend. Advertising for CCBs increased from 4.6% of advertising pages in 1985 to 26.9% in 1996, while advertising for beta-blockers (12.4% in 1985 to 0% in 1996) and diuretics (4.2% to 0%) decreased (all P |
| doi_str_mv | 10.1161/01.CIR.99.15.2055 |
| format | Article |
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We reviewed the January, April, July, and October issues of the New England Journal of Medicine from 1985 to 1996 (210 issues). The intensity of drug promotion was measured as the proportion of advertising pages used to promote a given medication. Statistical analyses used the chi2 test for trend. Advertising for CCBs increased from 4.6% of advertising pages in 1985 to 26.9% in 1996, while advertising for beta-blockers (12.4% in 1985 to 0% in 1996) and diuretics (4.2% to 0%) decreased (all P<0.0001). A nonsignificant increase was observed in advertising for ACE inhibitors (3.5% to 4.3%, P=0.17). Although the total number of drug advertising pages per issue decreased from 60 pages in 1985 to 42 pages in 1996 (P<0.001), the number of pages devoted to calcium channel blocker advertisements nearly quadrupled.
Increasing promotion of CCBs has mirrored trends in physician prescribing. An association between advertising and prescribing patterns could explain why CCBs have supplanted better-substantiated therapies for hypertension.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.99.15.2055</identifier><identifier>PMID: 10209012</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adrenergic beta-Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive agents ; Antihypertensive Agents - classification ; Benzothiadiazines ; Bibliometrics ; Biological and medical sciences ; Calcium Channel Blockers ; Cardiovascular system ; Diuretics ; Drug Industry - trends ; Drug Prescriptions - statistics & numerical data ; Drug Utilization - trends ; Humans ; Hypertension - drug therapy ; Hypertension - epidemiology ; Marketing of Health Services - statistics & numerical data ; Marketing of Health Services - trends ; Medical sciences ; Pharmacology. Drug treatments ; Practice Patterns, Physicians' - statistics & numerical data ; Publishing ; Sodium Chloride Symporter Inhibitors</subject><ispartof>Circulation (New York, N.Y.), 1999-04, Vol.99 (15), p.2055-2057</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Apr 20, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-98e002081a6595fe90c750431ebdabcba19b83c068f063506179d099234b3f453</citedby><cites>FETCH-LOGICAL-c438t-98e002081a6595fe90c750431ebdabcba19b83c068f063506179d099234b3f453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3674,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1743911$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10209012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, T. J</creatorcontrib><creatorcontrib>AUSIELLO, J. C</creatorcontrib><creatorcontrib>STAFFORD, R. S</creatorcontrib><title>Trends in antihypertensive drug advertising, 1985-1996</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Over the past decade, calcium channel blockers (CCBs) and ACE inhibitors have been used increasingly in the treatment of hypertension. In contrast, beta-blocker and diuretic use has decreased. It has been suggested that pharmaceutical marketing has influenced these prescribing patterns. No objective analysis of advertising for antihypertensive therapies exists, however.
We reviewed the January, April, July, and October issues of the New England Journal of Medicine from 1985 to 1996 (210 issues). The intensity of drug promotion was measured as the proportion of advertising pages used to promote a given medication. Statistical analyses used the chi2 test for trend. Advertising for CCBs increased from 4.6% of advertising pages in 1985 to 26.9% in 1996, while advertising for beta-blockers (12.4% in 1985 to 0% in 1996) and diuretics (4.2% to 0%) decreased (all P<0.0001). A nonsignificant increase was observed in advertising for ACE inhibitors (3.5% to 4.3%, P=0.17). Although the total number of drug advertising pages per issue decreased from 60 pages in 1985 to 42 pages in 1996 (P<0.001), the number of pages devoted to calcium channel blocker advertisements nearly quadrupled.
Increasing promotion of CCBs has mirrored trends in physician prescribing. An association between advertising and prescribing patterns could explain why CCBs have supplanted better-substantiated therapies for hypertension.</description><subject>Adrenergic beta-Antagonists</subject><subject>Angiotensin-Converting Enzyme Inhibitors</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Agents - classification</subject><subject>Benzothiadiazines</subject><subject>Bibliometrics</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers</subject><subject>Cardiovascular system</subject><subject>Diuretics</subject><subject>Drug Industry - trends</subject><subject>Drug Prescriptions - statistics & numerical data</subject><subject>Drug Utilization - trends</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - epidemiology</subject><subject>Marketing of Health Services - statistics & numerical data</subject><subject>Marketing of Health Services - trends</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Practice Patterns, Physicians' - statistics & numerical data</subject><subject>Publishing</subject><subject>Sodium Chloride Symporter Inhibitors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE9Lw0AQxRdRtFY_gBcJIp5MnNnNbnaOUvwHBUHqedkkG01J07rbFPz2bmlB8TTM8Hszbx5jFwgZosI7wGzy8pYRZSgzDlIesBFKnqe5FHTIRgBAaSE4P2GnIcxjq0Qhj9kJAgcC5COmZt71dUjaPrH9uv38Xjm_dn1oNy6p_fCR2HoTJ21o-4_bBEnLFInUGTtqbBfc-b6O2fvjw2zynE5fn14m99O0yoVep6QdxFMarZIkG0dQFRJyga6sbVmVFqnUogKlm2hNgsKCaiDiIi9FE78Ys5vd3pVffg0urM2iDZXrOtu75RCMIkWUo47g1T9wvhx8H70ZjrzItdBbCHdQ5ZcheNeYlW8X1n8bBLNN1ACamKghMijNNtGoudwvHsqFq_8odhFG4HoP2FDZrvG2r9rwyxW5IETxA8zxefc</recordid><startdate>19990420</startdate><enddate>19990420</enddate><creator>WANG, T. J</creator><creator>AUSIELLO, J. C</creator><creator>STAFFORD, R. S</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19990420</creationdate><title>Trends in antihypertensive drug advertising, 1985-1996</title><author>WANG, T. J ; AUSIELLO, J. C ; STAFFORD, R. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-98e002081a6595fe90c750431ebdabcba19b83c068f063506179d099234b3f453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adrenergic beta-Antagonists</topic><topic>Angiotensin-Converting Enzyme Inhibitors</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive Agents - classification</topic><topic>Benzothiadiazines</topic><topic>Bibliometrics</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers</topic><topic>Cardiovascular system</topic><topic>Diuretics</topic><topic>Drug Industry - trends</topic><topic>Drug Prescriptions - statistics & numerical data</topic><topic>Drug Utilization - trends</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - epidemiology</topic><topic>Marketing of Health Services - statistics & numerical data</topic><topic>Marketing of Health Services - trends</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Practice Patterns, Physicians' - statistics & numerical data</topic><topic>Publishing</topic><topic>Sodium Chloride Symporter Inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WANG, T. J</creatorcontrib><creatorcontrib>AUSIELLO, J. C</creatorcontrib><creatorcontrib>STAFFORD, R. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, T. J</au><au>AUSIELLO, J. C</au><au>STAFFORD, R. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in antihypertensive drug advertising, 1985-1996</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1999-04-20</date><risdate>1999</risdate><volume>99</volume><issue>15</issue><spage>2055</spage><epage>2057</epage><pages>2055-2057</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Over the past decade, calcium channel blockers (CCBs) and ACE inhibitors have been used increasingly in the treatment of hypertension. In contrast, beta-blocker and diuretic use has decreased. It has been suggested that pharmaceutical marketing has influenced these prescribing patterns. No objective analysis of advertising for antihypertensive therapies exists, however.
We reviewed the January, April, July, and October issues of the New England Journal of Medicine from 1985 to 1996 (210 issues). The intensity of drug promotion was measured as the proportion of advertising pages used to promote a given medication. Statistical analyses used the chi2 test for trend. Advertising for CCBs increased from 4.6% of advertising pages in 1985 to 26.9% in 1996, while advertising for beta-blockers (12.4% in 1985 to 0% in 1996) and diuretics (4.2% to 0%) decreased (all P<0.0001). A nonsignificant increase was observed in advertising for ACE inhibitors (3.5% to 4.3%, P=0.17). Although the total number of drug advertising pages per issue decreased from 60 pages in 1985 to 42 pages in 1996 (P<0.001), the number of pages devoted to calcium channel blocker advertisements nearly quadrupled.
Increasing promotion of CCBs has mirrored trends in physician prescribing. An association between advertising and prescribing patterns could explain why CCBs have supplanted better-substantiated therapies for hypertension.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10209012</pmid><doi>10.1161/01.CIR.99.15.2055</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors Antihypertensive agents Antihypertensive Agents - classification Benzothiadiazines Bibliometrics Biological and medical sciences Calcium Channel Blockers Cardiovascular system Diuretics Drug Industry - trends Drug Prescriptions - statistics & numerical data Drug Utilization - trends Humans Hypertension - drug therapy Hypertension - epidemiology Marketing of Health Services - statistics & numerical data Marketing of Health Services - trends Medical sciences Pharmacology. Drug treatments Practice Patterns, Physicians' - statistics & numerical data Publishing Sodium Chloride Symporter Inhibitors |
| title | Trends in antihypertensive drug advertising, 1985-1996 |
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