Cerebrospinal fluid S-100b concentrations in patients with HIV infection
S-100b is low molecular weight acidic calciumbinding protein that is present in high concentrations in the astrocytes of the central nervous system (CNS). In the non-HIV-infected general population, elevations of S-100b in the cerebrospinal fluid (CSF) are seen in destructive and inflammatory neurol...
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| Veröffentlicht in: | AIDS (London) 1999-01, Vol.13 (1), p.139-140 |
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| creator | GREEN, A. J. E GIOVANNONI, G MILLER, R. F HARRISON, M. J. G THOMPSON, E. J |
| description | S-100b is low molecular weight acidic calciumbinding protein that is present in high concentrations in the astrocytes of the central nervous system (CNS). In the non-HIV-infected general population, elevations of S-100b in the cerebrospinal fluid (CSF) are seen in destructive and inflammatory neurological disease, and measurement of CSF concentrations of S-100b have been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other dementias. There is increasing interest in the possiblity that astrocytes may be infected by HIV. We have prospectively evaluated whether measurement of S-100 in CSF is useful in the investigation of patients with HIV-associated dementia complex (HADC) and other neurological conditions. |
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J. E ; GIOVANNONI, G ; MILLER, R. F ; HARRISON, M. J. G ; THOMPSON, E. J</creator><creatorcontrib>GREEN, A. J. E ; GIOVANNONI, G ; MILLER, R. F ; HARRISON, M. J. G ; THOMPSON, E. J</creatorcontrib><description>S-100b is low molecular weight acidic calciumbinding protein that is present in high concentrations in the astrocytes of the central nervous system (CNS). In the non-HIV-infected general population, elevations of S-100b in the cerebrospinal fluid (CSF) are seen in destructive and inflammatory neurological disease, and measurement of CSF concentrations of S-100b have been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other dementias. There is increasing interest in the possiblity that astrocytes may be infected by HIV. We have prospectively evaluated whether measurement of S-100 in CSF is useful in the investigation of patients with HIV-associated dementia complex (HADC) and other neurological conditions.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>PMID: 10207559</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; AIDS/HIV ; AS-100b protein ; Biological and medical sciences ; Female ; HIV Infections - cerebrospinal fluid ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Nerve Growth Factors ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins - cerebrospinal fluid ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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J</creatorcontrib><title>Cerebrospinal fluid S-100b concentrations in patients with HIV infection</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>S-100b is low molecular weight acidic calciumbinding protein that is present in high concentrations in the astrocytes of the central nervous system (CNS). In the non-HIV-infected general population, elevations of S-100b in the cerebrospinal fluid (CSF) are seen in destructive and inflammatory neurological disease, and measurement of CSF concentrations of S-100b have been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other dementias. There is increasing interest in the possiblity that astrocytes may be infected by HIV. We have prospectively evaluated whether measurement of S-100 in CSF is useful in the investigation of patients with HIV-associated dementia complex (HADC) and other neurological conditions.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>AS-100b protein</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>HIV Infections - cerebrospinal fluid</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nerve Growth Factors</subject><subject>S100 Calcium Binding Protein beta Subunit</subject><subject>S100 Proteins - cerebrospinal fluid</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQBuAgiruu_gXJQbwVJmmbaY6yqLuw4MGPa0maBCPdtCYt4r834opHTzO88zAMc0SWrMKyqGtkx2QJXMhClggLcpbSGwDU0DSnZMGAA9a1XJLN2kar45BGH1RPXT97Qx8LBqBpN4TOhimqyQ8hUR_omNucJPrhp1e62b7k0Nnue35OTpzqk7041BV5vrt9Wm-K3cP9dn2zK0YucCpYqblDboyQomECUUsna4WNdKJiDpXpmNEIYBqDJp8hQGqmURqAnOpyRa5_9o5xeJ9tmtq9T53texXsMKc275UNSvgXMqxKZJJneHmAs95b047R71X8bH-flMHVAajUqd5FFTqf_pzgmG35BeqAbws</recordid><startdate>19990114</startdate><enddate>19990114</enddate><creator>GREEN, A. J. E</creator><creator>GIOVANNONI, G</creator><creator>MILLER, R. F</creator><creator>HARRISON, M. J. G</creator><creator>THOMPSON, E. 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Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GREEN, A. J. E</creatorcontrib><creatorcontrib>GIOVANNONI, G</creatorcontrib><creatorcontrib>MILLER, R. F</creatorcontrib><creatorcontrib>HARRISON, M. J. G</creatorcontrib><creatorcontrib>THOMPSON, E. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GREEN, A. J. E</au><au>GIOVANNONI, G</au><au>MILLER, R. F</au><au>HARRISON, M. J. G</au><au>THOMPSON, E. 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| fulltext | fulltext |
| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 1999-01, Vol.13 (1), p.139-140 |
| issn | 0269-9370 1473-5571 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult AIDS/HIV AS-100b protein Biological and medical sciences Female HIV Infections - cerebrospinal fluid Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Nerve Growth Factors S100 Calcium Binding Protein beta Subunit S100 Proteins - cerebrospinal fluid Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Cerebrospinal fluid S-100b concentrations in patients with HIV infection |
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