Serum free insulin-like growth factor-I is dose-dependently decreased by methylprednisolone and related to body weight changes in rats

Glucocorticoids usually inhibit growth despite a paradoxical increase in total IGF-I. To investigate the effect of methylprednisolone on free IGF-I, rats were treated with for 3 days (0, 1, 2, 4, and 6 mg/kg per day). A dose-dependent decrease in ultrafiltrated serum free IGF-I was observed, being l...

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Veröffentlicht in:	Growth hormone & IGF research 1999-02, Vol.9 (1), p.74-80
Hauptverfasser:	Skjærbæk, Christian, Frystyk, Jan, Grøfte, Thorbjørn, Flyvbjerg, Allan, Lewitt, Moira S., Baxter, Robert C., Ørskov, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - drug effects Blood Glucose - metabolism Body Weight - drug effects Body Weight - physiology Energy Intake - drug effects Fasting Female Glucocorticoids - administration & dosage Glucocorticoids - pharmacology Injections, Subcutaneous Insulin-Like Growth Factor Binding Protein 1 - blood Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - drug effects Insulin-Like Growth Factor I - metabolism Methylprednisolone - administration & dosage Methylprednisolone - pharmacology methylprednisolone, glucocorticoids, IGF-I, free IGF-I, IGF binding proteins, acid-labile subunit, growth, catabolism, rats Rats Rats, Wistar Regression Analysis Ultrafiltration
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Zusammenfassung:	Glucocorticoids usually inhibit growth despite a paradoxical increase in total IGF-I. To investigate the effect of methylprednisolone on free IGF-I, rats were treated with for 3 days (0, 1, 2, 4, and 6 mg/kg per day). A dose-dependent decrease in ultrafiltrated serum free IGF-I was observed, being lowest after 6 mg/kg (P
ISSN:	1096-6374 1532-2238
DOI:	10.1054/ghir.1999.0090