Critical Role of TLR9 in Acute Graft-versus-Host Disease

Graft-vs-host disease (GVHD) is a major complication after allogeneic bone marrow transplantation. Different studies have demonstrated that intestinal bacterial breakdown products and loss of gastrointestinal tract integrity, both induced by conditioning regiments, are critical in the pathogenesis o...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-11, Vol.181 (9), p.6132-6139
Hauptverfasser:	Calcaterra, Claudia, Sfondrini, Lucia, Rossini, Anna, Sommariva, Michele, Rumio, Cristiano, Menard, Sylvie, Balsari, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adoptive Transfer Animals Bone Marrow Transplantation - immunology Cells, Cultured Coculture Techniques Female Graft vs Host Disease - genetics Graft vs Host Disease - immunology Graft vs Host Disease - mortality Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Radiation Chimera - genetics Radiation Chimera - immunology Severity of Illness Index Survival Analysis Toll-Like Receptor 9 - deficiency Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - physiology Transplantation, Homologous
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