Can yeast systems biology contribute to the understanding of human disease?
Saccharomyces cerevisiae is a unicellular eukaryal microorganism that has traditionally been regarded either as a model system for investigating cellular physiology or as a cell factory for biotechnological use, for example for the production of fuels and commodity chemicals such as lactate or pharm...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2008-11, Vol.26 (11), p.584-590 |
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| creator | Petranovic, Dina Nielsen, Jens |
| description | Saccharomyces cerevisiae is a unicellular eukaryal microorganism that has traditionally been regarded either as a model system for investigating cellular physiology or as a cell factory for biotechnological use, for example for the production of fuels and commodity chemicals such as lactate or pharmaceuticals, including human insulin and HPV vaccines. Systems biology has recently gained momentum and has successfully been used for mapping complex regulatory networks and resolving the dynamics of signal transduction pathways. So far, yeast systems biology has mainly focused on the development of new methods and concepts. There are also some examples of the application of yeast systems biology for improving biotechnological processes. We discuss here how yeast systems biology could be used in elucidating fundamental cellular principles such as those relevant for the study of molecular mechanisms underlying complex human diseases, including the metabolic syndrome and ageing. |
| doi_str_mv | 10.1016/j.tibtech.2008.07.008 |
| format | Article |
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| subjects | Aging - genetics Aging - metabolism Biological and medical sciences Biology Biotechnology Data analysis Deoxyribonucleic acid Design of experiments DNA Fundamental and applied biological sciences. Psychology Genomes Genomics Health. Pharmaceutical industry Human papillomavirus Humans Industrial applications and implications. Economical aspects Internal Medicine Kinases Mathematical models Metabolic disorders Metabolic Syndrome - genetics Metabolic Syndrome - metabolism Miscellaneous Models, Biological Nervous System Diseases - genetics Nervous System Diseases - metabolism Neural networks Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology Signal Transduction - genetics Signal Transduction - physiology Studies Systems Biology Transcription factors Yeast Yeasts |
| title | Can yeast systems biology contribute to the understanding of human disease? |
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