A Role for CD99 in T Cell Activation

The function of the T cell surface protein CD99 was investigated in human CD4+peripheral T cells. Crosslinking of the CD99 molecule using anti-CD99 mAbs in the presence of anti-CD3 Ab resulted in a marked enhancement of proliferation. CD99 coligation also enhanced CD25 expression and early markers o...

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Veröffentlicht in:	Cellular immunology 1999-04, Vol.193 (1), p.17-23
Hauptverfasser:	Wingett, Denise, Forcier, Kristin, Nielson, Christopher P.
Format:	Artikel
Sprache:	eng
Schlagworte:	12E7 Antigen Antigens, CD - physiology CD2 Antigens - physiology CD28 Antigens - physiology CD3 Complex - immunology CD40 Ligand Cell Adhesion Molecules - physiology Humans Lymphocyte Activation Membrane Glycoproteins - analysis Phosphorylation Protein-Tyrosine Kinases - physiology T-Lymphocytes - immunology Tyrosine - metabolism Up-Regulation ZAP-70 Protein-Tyrosine Kinase
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