Bacterial solutions to the iron-supply problem
The insolubility of Fe 3+ necessitates special mechanisms for iron acquisition in most organisms. Bacteria use siderophores to chelate Fe 3+ and iron in heme, hemoglobin, transferrin and lactoferrin, and employ novel mechanisms for receptor-dependent iron transport and iron-regulated gene expression...
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| Veröffentlicht in: | Trends in Biochemical Sciences 1999-03, Vol.24 (3), p.104-109 |
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| container_title | Trends in Biochemical Sciences |
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| creator | Braun, Volkmar Killmann, Helmut |
| description | The insolubility of Fe
3+ necessitates special mechanisms for iron acquisition in most organisms. Bacteria use siderophores to chelate Fe
3+ and iron in heme, hemoglobin, transferrin and lactoferrin, and employ novel mechanisms for receptor-dependent iron transport and iron-regulated gene expression. These mechanisms involve transfer of energy from the cytoplasmic membrane to the outer membrane to drive active transport and might induce transcription of transport genes by transmitting a signal from the cell surface. |
| doi_str_mv | 10.1016/S0968-0004(99)01359-6 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Trends in Biochemical Sciences, 1999-03, Vol.24 (3), p.104-109 |
| issn | 0968-0004 1362-4326 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Bacteria - metabolism bacterial iron transport Cell Membrane - metabolism Energy Metabolism Ion Transport Iron - metabolism Models, Biological regulation Siderophores - metabolism toxicity |
| title | Bacterial solutions to the iron-supply problem |
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