Effects of an Onchocerca-derived cysteine protease inhibitor on microfilariae in their simuliid vector
A recombinant cysteine protease inhibitor, onchocystatin of the parasitic nematode Onchocerca volvulus, was tested for its role in microfilarial development in the simuliid vector. Onchocystatin was found to be present in female adults and skin microfilariae of the bovine parasite O. ochengi, the cl...
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| Veröffentlicht in: | Parasitology 1999-03, Vol.118 (3), p.305-310 |
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| container_title | Parasitology |
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| creator | KLÄGER, S. L. HAGEN, H.-E. BRADLEY, J. E. |
| description | A recombinant cysteine protease inhibitor, onchocystatin of the
parasitic nematode Onchocerca volvulus, was tested for its
role in microfilarial development in the simuliid vector. Onchocystatin
was found to be present in female adults and skin
microfilariae of the bovine parasite O. ochengi, the closest relative
of O. volvulus. In addition the inhibitor could be detected
as an excretory–secretory (E–S) product of the microfilariae.
Co-injection of onchocystatin and the O. ochengi microfilariae
into the surrogate vector Simulium ornatum s.l. significantly
enhanced the recovery rates of the parasite within 24 h into
the infection (P>0·001). The findings suggest a possible
role of onchocystatin in the evasion by the parasite of the immune
response of its vector. |
| doi_str_mv | 10.1017/S0031182098003795 |
| format | Article |
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parasitic nematode Onchocerca volvulus, was tested for its
role in microfilarial development in the simuliid vector. Onchocystatin
was found to be present in female adults and skin
microfilariae of the bovine parasite O. ochengi, the closest relative
of O. volvulus. In addition the inhibitor could be detected
as an excretory–secretory (E–S) product of the microfilariae.
Co-injection of onchocystatin and the O. ochengi microfilariae
into the surrogate vector Simulium ornatum s.l. significantly
enhanced the recovery rates of the parasite within 24 h into
the infection (P>0·001). The findings suggest a possible
role of onchocystatin in the evasion by the parasite of the immune
response of its vector.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182098003795</identifier><identifier>PMID: 10205807</identifier><identifier>CODEN: PARAAE</identifier><language>eng</language><publisher>Cambridge: Cambridge University Press</publisher><subject>Animals ; Biological and medical sciences ; Cattle ; Cattle Diseases - parasitology ; Cysteine Proteinase Inhibitors - metabolism ; development ; filariasis ; Fundamental and applied biological sciences. Psychology ; Helminth Proteins - metabolism ; Host parasite relation; pathogenicity ; Host-Parasite Interactions ; Immunoblotting ; insect immunity ; Insect Vectors - immunology ; Insect Vectors - parasitology ; Invertebrates ; Mice ; Mice, Inbred BALB C ; Nemathelminthia. Plathelmintha ; Onchocerca - growth & development ; Onchocerca - immunology ; Onchocerca - metabolism ; Onchocerciasis - parasitology ; Onchocerciasis - veterinary ; onchocystatin ; Simuliidae - immunology ; Simuliidae - parasitology</subject><ispartof>Parasitology, 1999-03, Vol.118 (3), p.305-310</ispartof><rights>1999 Cambridge University Press</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-badfacead71626c839c8a668ff1c2bf018282b86412808749a3a1b2715dfbec53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182098003795/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1778522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10205807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KLÄGER, S. L.</creatorcontrib><creatorcontrib>HAGEN, H.-E.</creatorcontrib><creatorcontrib>BRADLEY, J. E.</creatorcontrib><title>Effects of an Onchocerca-derived cysteine protease inhibitor on microfilariae in their simuliid vector</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>A recombinant cysteine protease inhibitor, onchocystatin of the
parasitic nematode Onchocerca volvulus, was tested for its
role in microfilarial development in the simuliid vector. Onchocystatin
was found to be present in female adults and skin
microfilariae of the bovine parasite O. ochengi, the closest relative
of O. volvulus. In addition the inhibitor could be detected
as an excretory–secretory (E–S) product of the microfilariae.
Co-injection of onchocystatin and the O. ochengi microfilariae
into the surrogate vector Simulium ornatum s.l. significantly
enhanced the recovery rates of the parasite within 24 h into
the infection (P>0·001). The findings suggest a possible
role of onchocystatin in the evasion by the parasite of the immune
response of its vector.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cattle Diseases - parasitology</subject><subject>Cysteine Proteinase Inhibitors - metabolism</subject><subject>development</subject><subject>filariasis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Helminth Proteins - metabolism</subject><subject>Host parasite relation; pathogenicity</subject><subject>Host-Parasite Interactions</subject><subject>Immunoblotting</subject><subject>insect immunity</subject><subject>Insect Vectors - immunology</subject><subject>Insect Vectors - parasitology</subject><subject>Invertebrates</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nemathelminthia. Plathelmintha</subject><subject>Onchocerca - growth & development</subject><subject>Onchocerca - immunology</subject><subject>Onchocerca - metabolism</subject><subject>Onchocerciasis - parasitology</subject><subject>Onchocerciasis - veterinary</subject><subject>onchocystatin</subject><subject>Simuliidae - immunology</subject><subject>Simuliidae - parasitology</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN2L1TAQxYMo7nX1D_BF8iC-VSfpbZI-6rJfsLDI-vEYpunEm7Vt1qRd3P_elHtRQfBpBs5vDmcOYy8FvBUg9LsbgFoII6E1ZdNt84htxFa1lRFKPGabVa5W_Yg9y_kWAFSt5FN2JEBCY0BvmD_1ntycefQcJ349uV10lBxWPaVwTz13D3mmMBG_S3EmzMTDtAtdmGPiceJjcCn6MGAKuEp83lFIPIdxGULo-X1xj-k5e-JxyPTiMI_Z57PTTycX1dX1-eXJ-6vKbcHMVYe9R0fYa6GkcqZunUGljPfCyc5D-cXIzqitkAaM3rZYo-ikFk3vO3JNfcze7H1L2B8L5dmOITsaBpwoLtmqVrVNo0wBxR4s6XNO5O1dCiOmByvAruXaf8otN68O5ks3Uv_Xxb7NArw-AJgdDj7h5EL-w2ltGikLVu2xUJr9-VvG9N0qXevGqvOP1sDZ1w9w88WutvUhK45dCv03srdxSVMp8j9pfwGwq6C_</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>KLÄGER, S. L.</creator><creator>HAGEN, H.-E.</creator><creator>BRADLEY, J. E.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Effects of an Onchocerca-derived cysteine protease inhibitor on microfilariae in their simuliid vector</title><author>KLÄGER, S. L. ; HAGEN, H.-E. ; BRADLEY, J. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-badfacead71626c839c8a668ff1c2bf018282b86412808749a3a1b2715dfbec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cattle Diseases - parasitology</topic><topic>Cysteine Proteinase Inhibitors - metabolism</topic><topic>development</topic><topic>filariasis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Helminth Proteins - metabolism</topic><topic>Host parasite relation; pathogenicity</topic><topic>Host-Parasite Interactions</topic><topic>Immunoblotting</topic><topic>insect immunity</topic><topic>Insect Vectors - immunology</topic><topic>Insect Vectors - parasitology</topic><topic>Invertebrates</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nemathelminthia. Plathelmintha</topic><topic>Onchocerca - growth & development</topic><topic>Onchocerca - immunology</topic><topic>Onchocerca - metabolism</topic><topic>Onchocerciasis - parasitology</topic><topic>Onchocerciasis - veterinary</topic><topic>onchocystatin</topic><topic>Simuliidae - immunology</topic><topic>Simuliidae - parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KLÄGER, S. L.</creatorcontrib><creatorcontrib>HAGEN, H.-E.</creatorcontrib><creatorcontrib>BRADLEY, J. E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KLÄGER, S. L.</au><au>HAGEN, H.-E.</au><au>BRADLEY, J. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of an Onchocerca-derived cysteine protease inhibitor on microfilariae in their simuliid vector</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>118</volume><issue>3</issue><spage>305</spage><epage>310</epage><pages>305-310</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><coden>PARAAE</coden><abstract>A recombinant cysteine protease inhibitor, onchocystatin of the
parasitic nematode Onchocerca volvulus, was tested for its
role in microfilarial development in the simuliid vector. Onchocystatin
was found to be present in female adults and skin
microfilariae of the bovine parasite O. ochengi, the closest relative
of O. volvulus. In addition the inhibitor could be detected
as an excretory–secretory (E–S) product of the microfilariae.
Co-injection of onchocystatin and the O. ochengi microfilariae
into the surrogate vector Simulium ornatum s.l. significantly
enhanced the recovery rates of the parasite within 24 h into
the infection (P>0·001). The findings suggest a possible
role of onchocystatin in the evasion by the parasite of the immune
response of its vector.</abstract><cop>Cambridge</cop><pub>Cambridge University Press</pub><pmid>10205807</pmid><doi>10.1017/S0031182098003795</doi><tpages>6</tpages></addata></record> |
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| ispartof | Parasitology, 1999-03, Vol.118 (3), p.305-310 |
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| source | Cambridge Journals Online; MEDLINE |
| subjects | Animals Biological and medical sciences Cattle Cattle Diseases - parasitology Cysteine Proteinase Inhibitors - metabolism development filariasis Fundamental and applied biological sciences. Psychology Helminth Proteins - metabolism Host parasite relation pathogenicity Host-Parasite Interactions Immunoblotting insect immunity Insect Vectors - immunology Insect Vectors - parasitology Invertebrates Mice Mice, Inbred BALB C Nemathelminthia. Plathelmintha Onchocerca - growth & development Onchocerca - immunology Onchocerca - metabolism Onchocerciasis - parasitology Onchocerciasis - veterinary onchocystatin Simuliidae - immunology Simuliidae - parasitology |
| title | Effects of an Onchocerca-derived cysteine protease inhibitor on microfilariae in their simuliid vector |
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