Evaluation of the clearance characteristics of bioadhesive systems in humans

This paper describes the characterisation, radiolabelling and clearance characteristics of three bioadhesive nasal delivery systems; starch microspheres, chitosan microspheres and chitosan solution. The time taken for 50% of these bioadhesive materials and a control to be cleared from the nasal cavi...

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Veröffentlicht in:	International journal of pharmaceutics 1999-02, Vol.178 (1), p.55-65
Hauptverfasser:	Soane, R.J, Frier, M, Perkins, A.C, Jones, N.S, Davis, S.S, Illum, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Administration, Intranasal Administration, Topical Adolescent Adult Bioadhesive polymers Biological and medical sciences Chitin - analogs & derivatives Chitin - pharmacokinetics Chitosan Delayed-Action Preparations - pharmacokinetics Female General pharmacology Humans Male Medical sciences Microspheres Mucoadhesion and gamma scintigraphy Nasal drug delivery Nasal Mucosa - physiology Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Radionuclide Imaging Starch Starch - pharmacokinetics Viscosity
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