Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process

The aim of this study is to propose a strategy to implement a PAT system in the blending step of pharmaceutical production processes. It was examined whether Raman spectroscopy can be used as PAT tool for the in-line and real-time endpoint monitoring and understanding of a powder blending process. A...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2008-11, Vol.48 (3), p.772-779
Hauptverfasser:	De Beer, T.R.M., Bodson, C., Dejaegher, B., Walczak, B., Vercruysse, P., Burggraeve, A., Lemos, A., Delattre, L., Heyden, Y. Vander, Remon, J.P., Vervaet, C., Baeyens, W.R.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Blending Cellulose - chemistry Chemistry, Pharmaceutical - methods Diltiazem - analysis Drug Carriers Drug Compounding - methods Experimental design Fundamental and applied biological sciences. Psychology General pharmacology In-line monitoring Lactose - chemistry Medical sciences NIR spectroscopy Orthogonal distance PAT Pharmacology. Drug treatments Powders Process understanding Raman spectroscopy Silicon Dioxide - chemistry SIMCA Spectroscopy, Near-Infrared - methods Spectrum Analysis, Raman - methods Technology, Pharmaceutical - methods
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