The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been shown to induce apoptosis in cancer cells but not normal cells. TRAIL triggers apoptosis through binding to its receptors DR4 and KILLER/DR5. Chemo or radiotherapy induces apoptosis...

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Veröffentlicht in:	Oncogene 2008-10, Vol.27 (48), p.6207-6215
1. Verfasser:	Wang, S
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Apoptosis - drug effects Bcl-2 protein Cancer Care and treatment Cell Biology Cell receptors Chemotherapy Control Death receptors Genetic aspects Genetics Health aspects Human Genetics Humans IAP protein Internal Medicine Ligands Medicine Medicine & Public Health Metastases Mutation Neoplasms - drug therapy Neoplasms - pathology Oncology p53 Protein Radiation therapy Receptors, TNF-Related Apoptosis-Inducing Ligand - drug effects review TNF-Related Apoptosis-Inducing Ligand - drug effects TRAIL protein Tumor necrosis factor Tumor necrosis factor-TNF Tumors
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