Microglia as mediators of inflammatory and degenerative diseases
Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediat...
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| Veröffentlicht in: | Annual review of neuroscience 1999-01, Vol.22 (1), p.219-240 |
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| container_title | Annual review of neuroscience |
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| creator | GONZALEZ-SCARANO, F BALTUCH, G |
| description | Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease. |
| doi_str_mv | 10.1146/annurev.neuro.22.1.219 |
| format | Article |
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Psychology</subject><subject>HIV Infections - physiopathology</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Inflammation - physiopathology</subject><subject>Isolated neuron and nerve. 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Psychology</topic><topic>HIV Infections - physiopathology</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Inflammation - physiopathology</topic><topic>Isolated neuron and nerve. 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| identifier | ISSN: 0147-006X |
| ispartof | Annual review of neuroscience, 1999-01, Vol.22 (1), p.219-240 |
| issn | 0147-006X 1545-4126 |
| language | eng |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | AIDS/HIV Alzheimer Disease - physiopathology Animals Biological and medical sciences Central Nervous System Diseases - physiopathology Fundamental and applied biological sciences. Psychology HIV Infections - physiopathology Human immunodeficiency virus 1 Humans Inflammation - physiopathology Isolated neuron and nerve. Neuroglia Microglia - physiology Multiple Sclerosis - physiopathology Nerve Degeneration - physiopathology Vertebrates: nervous system and sense organs |
| title | Microglia as mediators of inflammatory and degenerative diseases |
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