Nongenomic actions of thyroxine modulate intermediate filament phosphorylation in cerebral cortex of rats

Abstract The developmental effects of thyroid hormones (TH) in mammalian brain are mainly mediated by nuclear receptors regulating gene expression. However, there are increasing evidences of nongenomic mechanisms of these hormones associated with kinase- and calcium-activated signaling pathways. In...

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Veröffentlicht in:	Neuroscience 2008-10, Vol.156 (3), p.640-652
Hauptverfasser:	Zamoner, A, Heimfarth, L, Oliveira Loureiro, S, Royer, C, Mena Barreto Silva, F.R, Pessoa-Pureur, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Animals, Newborn Autoradiography - methods Biological and medical sciences calcium Calcium - metabolism cell signaling Cerebral Cortex - drug effects Chelating Agents - pharmacology Cyclic AMP - metabolism cytoskeleton Dose-Response Relationship, Drug Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism In Vitro Techniques Intermediate Filaments - metabolism l-thyroxine Male Neurology Pertussis Toxin - pharmacology Phosphorylation - drug effects protein kinases Rats Rats, Wistar Signal Transduction - drug effects Thyroxine - pharmacology Time Factors Vertebrates: nervous system and sense organs Vimentin - metabolism
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