Amisulpride the ‘atypical’ atypical antipsychotic — Comparison to haloperidol, risperidone and clozapine

Abstract Introduction Amisulpride's high and selective affinity for dopamine D2/3 (Ki 1.3/2.4 nM) receptors, lack of affinity for serotonin receptors, and its unusually high therapeutic doses (400–800 mg/day) makes it unique among atypical antipsychotics and prompted us to compare its actions w...

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Veröffentlicht in:	Schizophrenia research 2008-10, Vol.105 (1), p.224-235
Hauptverfasser:	Natesan, Sridhar, Reckless, Greg E, Barlow, Karren B.L, Nobrega, José N, Kapur, Shitij
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT 2 receptor occupancy Amisulpride Amphetamine - antagonists & inhibitors Amphetamine - pharmacology Animals Antipsychotic Agents - metabolism Antipsychotic Agents - pharmacology Antipsychotic animal models Basal Ganglia - drug effects Basal Ganglia - metabolism Behavior, Animal - drug effects Biological and medical sciences Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain - drug effects Brain - metabolism Clozapine - metabolism Clozapine - pharmacology Conditioning (Psychology) - drug effects D 2/3 receptor occupancy Haloperidol - metabolism Haloperidol - pharmacology Male Medical sciences Models, Animal Motor Activity - drug effects Neuropharmacology Pharmacology. Drug treatments Phencyclidine - antagonists & inhibitors Phencyclidine - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Prolactin - blood Prolactin - drug effects Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - drug effects Receptors, Dopamine D3 - metabolism Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Risperidone - metabolism Risperidone - pharmacology Schizophrenia Sulpiride - analogs & derivatives Sulpiride - metabolism Sulpiride - pharmacology
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