Trigeminal activation using chemical, electrical, and mechanical stimuli
Tactile, proprioceptive, and nociceptive information, including also chemosensory functions are expressed in the trigeminal nerve sensory response. To study differences in the processing of different stimulus qualities, we performed a study based on functional magnetic resonance imaging. The first t...
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| Veröffentlicht in: | Pain (Amsterdam) 2008-10, Vol.139 (2), p.376-388 |
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| creator | Iannilli, E. Del Gratta, C. Gerber, J.C. Romani, G.L. Hummel, T. |
| description | Tactile, proprioceptive, and nociceptive information, including also chemosensory functions are expressed in the trigeminal nerve sensory response. To study differences in the processing of different stimulus qualities, we performed a study based on functional magnetic resonance imaging. The first trigeminal branch (ophthalmic nerve) was activated by (a) intranasal chemical stimulation with gaseous CO
2 which produces stinging and burning sensations, but is virtually odorless, (b) painful, but not nociceptive specific cutaneous electrical stimulation, and (c) cutaneous mechanical stimulation using air puffs. Eighteen healthy subjects participated (eight men, 10 women, mean age 31 years). Painful stimuli produced patterns of activation similar to what has been reported for other noxious stimuli, namely activation in the primary and secondary somatosensory cortices, anterior cingulate cortex, insular cortex, and thalamus. In addition, analyses indicated intensity-related activation in the prefrontal cortex which was specifically involved in the evaluation of stimulus intensity. Importantly, the results also indicated similarities between activation patterns after intranasal chemosensory trigeminal stimulation and patterns usually found following intranasal odorous stimulation, indicating the intimate connection between these two systems in the processing of sensory information. |
| doi_str_mv | 10.1016/j.pain.2008.05.007 |
| format | Article |
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2 which produces stinging and burning sensations, but is virtually odorless, (b) painful, but not nociceptive specific cutaneous electrical stimulation, and (c) cutaneous mechanical stimulation using air puffs. Eighteen healthy subjects participated (eight men, 10 women, mean age 31 years). Painful stimuli produced patterns of activation similar to what has been reported for other noxious stimuli, namely activation in the primary and secondary somatosensory cortices, anterior cingulate cortex, insular cortex, and thalamus. In addition, analyses indicated intensity-related activation in the prefrontal cortex which was specifically involved in the evaluation of stimulus intensity. Importantly, the results also indicated similarities between activation patterns after intranasal chemosensory trigeminal stimulation and patterns usually found following intranasal odorous stimulation, indicating the intimate connection between these two systems in the processing of sensory information.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chemosensory</subject><subject>Electric Stimulation - methods</subject><subject>Evoked Potentials, Somatosensory - physiology</subject><subject>Female</subject><subject>fMRI</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Olfaction</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Pain</subject><subject>Physical Stimulation - methods</subject><subject>Smell - physiology</subject><subject>Somatosensory Cortex - physiology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Trigeminal</subject><subject>Trigeminal Nerve - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGP1SAUhYnROG9G_4AL042ubL1AoTRxYyY6YzKJm3FNeHA7jyelT2hn4r-Xpi-6cwVcvnPP5UDIGwoNBSo_HpuT8bFhAKoB0QB0z8iOqo7VUjL-nOyAQ1vzXvQX5DLnIwAwxvqX5IIqoTgI2JHb--QfcPTRhMrY2T-a2U-xWrKPD5U9lBtrwocKA9o5bXsTXTWiPZi4nqs8-3EJ_hV5MZiQ8fV5vSI_vn65v76t777ffLv-fFfbtheqZl3fUdEqzqgR4KxVsrMSHOuAtcbspZPtgHslLB_cQAcBCB1rBUXKneo4vyLvt76nNP1aMM969NliCCbitGQte6l6KkUB2QbaNOWccNCn5EeTfmsKes1PH_Wan17z0yB0ya-I3p67L_sR3T_JObACvDsDJpfXD8lE6_NfjkFX_DkrXLtxT1OYMeWfYXnCpA9ownwoVgCS97JevcssAupSoarIPm0yLBE--qLI1mO06HwqP6Dd5P83_h8Mt5z1</recordid><startdate>20081015</startdate><enddate>20081015</enddate><creator>Iannilli, E.</creator><creator>Del Gratta, C.</creator><creator>Gerber, J.C.</creator><creator>Romani, G.L.</creator><creator>Hummel, T.</creator><general>Elsevier B.V</general><general>Lippincott Williams & Wilkins, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081015</creationdate><title>Trigeminal activation using chemical, electrical, and mechanical stimuli</title><author>Iannilli, E. ; Del Gratta, C. ; Gerber, J.C. ; Romani, G.L. ; Hummel, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4958-27971548321a50dcc867c60d27024aab6d64feb85c3fdf1f50e072451e13d8733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chemosensory</topic><topic>Electric Stimulation - methods</topic><topic>Evoked Potentials, Somatosensory - physiology</topic><topic>Female</topic><topic>fMRI</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Olfaction</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Pain</topic><topic>Physical Stimulation - methods</topic><topic>Smell - physiology</topic><topic>Somatosensory Cortex - physiology</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Trigeminal</topic><topic>Trigeminal Nerve - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iannilli, E.</creatorcontrib><creatorcontrib>Del Gratta, C.</creatorcontrib><creatorcontrib>Gerber, J.C.</creatorcontrib><creatorcontrib>Romani, G.L.</creatorcontrib><creatorcontrib>Hummel, T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iannilli, E.</au><au>Del Gratta, C.</au><au>Gerber, J.C.</au><au>Romani, G.L.</au><au>Hummel, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trigeminal activation using chemical, electrical, and mechanical stimuli</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>2008-10-15</date><risdate>2008</risdate><volume>139</volume><issue>2</issue><spage>376</spage><epage>388</epage><pages>376-388</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><coden>PAINDB</coden><abstract>Tactile, proprioceptive, and nociceptive information, including also chemosensory functions are expressed in the trigeminal nerve sensory response. To study differences in the processing of different stimulus qualities, we performed a study based on functional magnetic resonance imaging. The first trigeminal branch (ophthalmic nerve) was activated by (a) intranasal chemical stimulation with gaseous CO
2 which produces stinging and burning sensations, but is virtually odorless, (b) painful, but not nociceptive specific cutaneous electrical stimulation, and (c) cutaneous mechanical stimulation using air puffs. Eighteen healthy subjects participated (eight men, 10 women, mean age 31 years). Painful stimuli produced patterns of activation similar to what has been reported for other noxious stimuli, namely activation in the primary and secondary somatosensory cortices, anterior cingulate cortex, insular cortex, and thalamus. In addition, analyses indicated intensity-related activation in the prefrontal cortex which was specifically involved in the evaluation of stimulus intensity. Importantly, the results also indicated similarities between activation patterns after intranasal chemosensory trigeminal stimulation and patterns usually found following intranasal odorous stimulation, indicating the intimate connection between these two systems in the processing of sensory information.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18583050</pmid><doi>10.1016/j.pain.2008.05.007</doi><tpages>13</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Chemosensory Electric Stimulation - methods Evoked Potentials, Somatosensory - physiology Female fMRI Fundamental and applied biological sciences. Psychology Humans Magnetic Resonance Imaging Male Olfaction Olfactory system and olfaction. Gustatory system and gustation Pain Physical Stimulation - methods Smell - physiology Somatosensory Cortex - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Trigeminal Trigeminal Nerve - physiology Vertebrates: nervous system and sense organs |
| title | Trigeminal activation using chemical, electrical, and mechanical stimuli |
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